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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Thyrotropin-releasing hormone receptor
Species	Homo sapiens (Human)
Gene	TRHR
Synonym	Thyroliberin receptor TRH receptor TRH-R TRH-R1 TRH1 receptor
Disease	Unspecified Pain Neurodegenerative disease Endocrine disease Cognitive disorders CNS stimulant [ Show all ]
Length	398
Amino acid sequence	MENETVSELNQTQLQPRAVVALEYQVVTILLVLIICGLGIVGNIMVVLVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSLYCMLWFFLLDLNISTYKDAIVISCGYKISRNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNPIPSDPKENSKTWKNDSTHQNTNLNVNTSNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKPANYSVALNYSVIKESDHFSTELDDITVTDTYLSATKVSFDDTCLASEVSFSQS
UniProt	P34981
Protein Data Bank	N/A
GPCR-HGmod model	P34981
3D structure model	This predicted structure model is from GPCR-EXP P34981.
BioLiP	N/A
Therapeutic Target Database	T77796
ChEMBL	CHEMBL1810
IUPHAR	363
DrugBank	BE0008659

Ligand

Name	MLS000689985
Molecular formula	C23H17NO4
IUPAC name	4-[3-[(1,3-dioxoinden-2-ylidene)methyl]-2,5-dimethylpyrrol-1-yl]benzoic acid
Molecular weight	371.392
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	4.2
Synonyms	HMS3364K06 4-{3-[(1,3-dioxo-1,3-dihydro-2H-inden-2-ylidene)methyl]-2,5-dimethyl-1H-pyrrol-1-yl}benzoic acid BDBM52601 MolPort-002-217-970 cid_1233277 SMR000298711 4-[3-[(1,3-dioxoinden-2-ylidene)methyl]-2,5-dimethylpyrrol-1-yl]benzoic acid MCULE-7379508216 AC1LO4NN REGID_for_CID_1233277 4-[3-[(1,3-diketoindan-2-ylidene)methyl]-2,5-dimethyl-pyrrol-1-yl]benzoic acid HMS2635G21 ZINC4758608 4-[3-[[1,3-bis(oxidanylidene)inden-2-ylidene]methyl]-2,5-dimethyl-pyrrol-1-yl]benzoic acid AKOS001642861 CHEMBL1304473 REGID_for_CID_242789 4-[3-[(1,3-dioxo-2-indenylidene)methyl]-2,5-dimethyl-1-pyrrolyl]benzoic acid [ Show all ]
Inchi Key	AYWOBRMNACLWLN-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H17NO4/c1-13-11-16(12-20-21(25)18-5-3-4-6-19(18)22(20)26)14(2)24(13)17-9-7-15(8-10-17)23(27)28/h3-12H,1-2H3,(H,27,28)
PubChem CID	1233277
ChEMBL	CHEMBL1304473
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	18356.4 nM	PubChem BioAssay data set	ChEMBL

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