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| Name | 5-hydroxytryptamine receptor 4 |
|---|---|
| Species | Cavia porcellus (Guinea pig) |
| Gene | HTR4 |
| Synonym | 5-HT-4 5-HT4 Serotonin receptor 4 |
| Disease | N/A for non-human GPCRs |
| Length | 388 |
| Amino acid sequence | MDKLDANVSSKEGFGSVEKVVLLTFLSAVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWVYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHARQIQVLQRAGAPAEGRPQPADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQLWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRDTVECGGQWESQCHPAASSPLVAAQPIDT |
| UniProt | O70528 |
| Protein Data Bank | N/A |
| GPCR-HGmod model | N/A |
| 3D structure model | No available structures or models |
| BioLiP | N/A |
| Therapeutic Target Database | N/A |
| ChEMBL | CHEMBL5017 |
| IUPHAR | N/A |
| DrugBank | N/A |
You can:
| GLASS ID | Molecule | Formula | Molecular weight | H-bond acceptor / donor | XlogP | Lipinski's druglikeness |
|---|---|---|---|---|---|---|
| 2921 |  CHEMBL2181190 | C22H25FN2O | 352.453 | 4 / 0 | 5.5 | No |
| 555497 |  BIMU-8 | C19H26N4O2 | 342.443 | 3 / 1 | 2.5 | Yes |
| 4336 |  CHEMBL59834 | C19H26N4O2 | 342.443 | 3 / 1 | 2.5 | Yes |
| 5154 |  CHEMBL511794 | C18H23N3OS | 329.462 | 4 / 0 | 4.7 | Yes |
| 5254 |  SB-258719 | C18H30N2O2S | 338.51 | 4 / 0 | 3.5 | Yes |
| 5615 |  CHEMBL3093189 | C21H21F3N2O | 374.407 | 6 / 0 | 5.6 | No |
| 7950 |  CHEMBL95661 | C20H29N5O2 | 371.485 | 4 / 1 | 2.4 | Yes |
| 8509 |  CHEMBL471234 | C17H21N3OS | 315.435 | 4 / 0 | 4.4 | Yes |
| 9171 |  CHEMBL36558 | C21H29N3O | 339.483 | 4 / 1 | 4.4 | Yes |
| 10288 |  doxorubicin | C27H29NO11 | 543.525 | 12 / 6 | 1.3 | No |
| 442111 |  Epirubicin | C27H29NO11 | 543.525 | 12 / 6 | 1.3 | No |
| 10437 |  SB 204070 hydrochloride | C19H27ClN2O4 | 382.885 | 6 / 1 | 3.5 | Yes |
| 11365 |  CHEMBL434999 | C17H19ClN4O | 330.816 | 4 / 2 | 2.0 | Yes |
| 12656 |  CHEMBL3218864 | C21H21N3OS | 363.479 | 4 / 0 | 5.3 | No |
| 15383 |  CHEMBL1290805 | C19H22IN3OS | 467.369 | 4 / 0 | 5.5 | No |
| 442318 |  CHEMBL3417004 | C22H34ClN3O2 | 407.983 | 5 / 2 | 5.2 | No |
| 17195 |  CHEMBL293866 | C20H19N3O | 317.392 | 4 / 0 | 4.2 | Yes |
| 557843 |  CHEMBL75420 | C18H27N5O | 329.448 | 3 / 3 | 3.4 | Yes |
| 19240 |  CHEMBL156499 | C16H24ClN3O2 | 325.837 | 4 / 1 | 2.2 | Yes |
| 19837 |  CHEMBL2440451 | C22H31N3O3 | 385.508 | 4 / 2 | 3.3 | Yes |
| 557907 |  CHEMBL76552 | C18H27N5O | 329.448 | 3 / 3 | 3.7 | Yes |
| 21229 |  (RS)-PPCC | C24H29NO3 | 379.5 | 4 / 1 | 3.5 | Yes |
| 21912 |  CHEMBL85602 | C23H28N2OS | 380.55 | 3 / 0 | 4.1 | Yes |
| 22324 |  CHEMBL363466 | C20H25NO2 | 311.425 | 3 / 0 | 4.2 | Yes |
| 22525 |  ethinyl estradiol | C20H24O2 | 296.41 | 2 / 2 | 3.7 | Yes |
| 23970 |  CHEMBL2440453 | C22H31N3O3 | 385.508 | 4 / 2 | 2.5 | Yes |
| 24087 |  CHEMBL36120 | C20H27N3O | 325.456 | 4 / 1 | 4.0 | Yes |
| 24285 |  CHEMBL2181168 | C21H24IN3O | 461.347 | 4 / 0 | 5.1 | No |
| 24610 |  CHEMBL3093193 | C22H20F6N2O | 442.405 | 9 / 0 | 6.4 | No |
| 25521 |  CHEMBL469582 | C18H23N3OS | 329.462 | 4 / 0 | 4.8 | Yes |
| 25962 |  CHEMBL1258786 | C19H29FN2O3 | 352.45 | 6 / 1 | 3.4 | Yes |
| 26201 |  RS 39604 | C26H36ClN3O6S | 554.099 | 9 / 2 | 3.1 | No |
| 26942 |  terconazole | C26H31Cl2N5O3 | 532.466 | 7 / 0 | 4.8 | No |
| 27263 |  CHEMBL512885 | C17H21N3OS | 315.435 | 4 / 0 | 4.7 | Yes |
| 29547 |  CHEMBL158147 | C18H25ClN2O3 | 352.859 | 5 / 1 | 3.2 | Yes |
| 29763 |  CHEMBL364005 | C14H15ClN2 | 246.738 | 1 / 2 | 2.8 | Yes |
| 30302 |  BRL-25594 | C22H26ClN3O2 | 399.919 | 4 / 2 | 3.8 | Yes |
| 31147 |  CHEMBL566522 | C19H19FN6 | 350.401 | 5 / 1 | 2.9 | Yes |
| 558260 |  CHEMBL74594 | C20H29N5O | 355.486 | 3 / 3 | 4.1 | Yes |
| 32209 |  CHEMBL1290804 | C19H21N3OS | 339.457 | 4 / 0 | 4.4 | Yes |
| 32954 |  CHEMBL155917 | C17H25ClN2O3 | 340.848 | 5 / 1 | 3.4 | Yes |
| 33637 |  CHEMBL1258672 | C18H27FN2O3 | 338.423 | 6 / 1 | 3.5 | Yes |
| 558315 |  CHEMBL77642 | C15H22N6O | 302.382 | 4 / 3 | 2.4 | Yes |
| 33955 |  Clebopride | C20H24ClN3O2 | 373.881 | 4 / 2 | 3.2 | Yes |
| 33974 |  CHEMBL319886 | C21H33N5O2 | 387.528 | 4 / 1 | 3.0 | Yes |
| 37004 |  CHEMBL99590 | C18H25N5O2 | 343.431 | 4 / 1 | 1.5 | Yes |
| 558427 |  CHEMBL74554 | C18H19N5O | 321.384 | 3 / 4 | 2.4 | Yes |
| 443251 |  152121-47-6 | C21H16FN3OS | 377.437 | 5 / 1 | 3.2 | Yes |
| 39518 |  CHEMBL470433 | C21H29N3OS | 371.543 | 4 / 0 | 6.1 | No |
| 40139 |  CHEMBL469593 | C18H23N3OS | 329.462 | 4 / 0 | 4.8 | Yes |
| 558515 |  CHEMBL307000 | C19H20N6O2 | 364.409 | 4 / 5 | 1.5 | Yes |
| 41529 |  CHEMBL513537 | C19H25N3OS | 343.489 | 4 / 0 | 5.3 | No |
| 42998 |  CHEMBL3218878 | C21H27N3OS | 369.527 | 4 / 0 | 5.8 | No |
| 45074 |  CHEMBL99452 | C17H23N5O2 | 329.404 | 4 / 1 | 1.6 | Yes |
| 48081 |  CHEMBL442261 | C21H25N3O | 335.451 | 4 / 1 | 3.8 | Yes |
| 48301 |  CHEMBL156088 | C17H24ClN2O3+ | 339.84 | 4 / 1 | 2.6 | Yes |
| 48580 |  CHEMBL3093188 | C21H22F2N2O | 356.417 | 5 / 0 | 5.4 | No |
| 443671 |  CHEMBL3417006 | C22H35ClN2O2 | 394.984 | 4 / 2 | 4.9 | Yes |
| 50188 |  CHEMBL466462 | C18H20FN5O2 | 357.389 | 7 / 2 | -0.4 | Yes |
| 50194 |  CHEMBL511555 | C18H20FN5O2 | 357.389 | 7 / 2 | -0.4 | Yes |
| 54222 |  CHEMBL143582 | C20H20N4O2 | 348.406 | 3 / 5 | 2.3 | Yes |
| 54295 |  CHEMBL99578 | C16H23N5O2 | 317.393 | 4 / 1 | 0.9 | Yes |
| 54527 |  CHEMBL471663 | C19H25N3OS | 343.489 | 4 / 0 | 5.2 | No |
| 55115 |  CHEMBL500336 | C16H19N3OS | 301.408 | 4 / 1 | 4.0 | Yes |
| 56029 |  CHEMBL2181185 | C22H25FN2O | 352.453 | 4 / 0 | 5.5 | No |
| 56665 |  cisapride | C23H29ClFN3O4 | 465.95 | 7 / 2 | 3.4 | Yes |
| 56671 |  cisapride | C23H29ClFN3O4 | 465.95 | 7 / 2 | 3.4 | Yes |
| 56750 |  CHEMBL426216 | C21H34ClN5O2 | 423.986 | 6 / 3 | 1.6 | Yes |
| 57863 |  CHEMBL156348 | C17H24ClN3O4 | 369.846 | 6 / 2 | 1.6 | Yes |
| 58205 |  CHEMBL143426 | C19H26N2O2 | 314.429 | 3 / 1 | 4.7 | Yes |
| 58812 |  CHEMBL328641 | C25H31N5O4 | 465.554 | 6 / 1 | 3.0 | Yes |
| 444046 |  CHEMBL3414597 | C19H27ClN2O2 | 350.887 | 4 / 1 | 3.3 | Yes |
| 61703 |  CHEMBL201878 | C16H19N3O2 | 285.347 | 4 / 1 | 2.7 | Yes |
| 62097 |  CHEMBL132826 | C18H25NO4 | 319.401 | 5 / 0 | 3.6 | Yes |
| 62368 |  CHEMBL48698 | C15H22ClN3O3 | 327.809 | 5 / 2 | 2.3 | Yes |
| 62593 |  CHEMBL140153 | C15H22ClN3O | 295.811 | 3 / 1 | 2.1 | Yes |
| 559209 |  CHEMBL307041 | C22H25N5O2 | 391.475 | 4 / 3 | 4.0 | Yes |
| 64030 |  CHEMBL174935 | C22H36ClN5O2 | 438.013 | 6 / 3 | 1.9 | Yes |
| 64581 |  CHEMBL142687 | C14H16ClN5OS | 337.826 | 6 / 2 | 1.6 | Yes |
| 65020 |  CHEMBL95235 | C20H31N5O2 | 373.501 | 4 / 1 | 2.5 | Yes |
| 65034 |  CHEMBL513254 | C19H23N3OS | 341.473 | 4 / 0 | 5.0 | Yes |
| 68661 |  CHEMBL159825 | C15H20ClN3O2 | 309.794 | 4 / 2 | 1.7 | Yes |
| 69972 |  CHEMBL2181184 | C23H28N2O | 348.49 | 3 / 0 | 5.8 | No |
| 71662 |  CHEMBL82976 | C27H38ClN3O6S | 568.126 | 9 / 2 | 3.5 | No |
| 73179 |  CHEMBL1258452 | C18H28N2O3 | 320.433 | 5 / 1 | 3.1 | Yes |
| 73639 |  CHEMBL3291075 | C19H24N2O3 | 328.412 | 5 / 0 | 3.6 | Yes |
| 74575 |  CHEMBL143862 | C23H32N2O3 | 384.52 | 4 / 0 | 4.6 | Yes |
| 74715 |  CHEMBL337101 | C19H19N5S | 349.456 | 5 / 0 | 3.6 | Yes |
| 75018 |  SB207710 | C19H27IN2O4 | 474.339 | 6 / 1 | 3.5 | Yes |
| 75430 |  CHEMBL512723 | C15H17N3OS | 287.381 | 4 / 1 | 3.5 | Yes |
| 75663 |  CHEMBL3218879 | C22H29N3OS | 383.554 | 4 / 0 | 6.3 | No |
| 76279 |  CHEMBL35972 | C19H25N3O | 311.429 | 4 / 1 | 3.7 | Yes |
| 76359 |  ondansetron | C18H19N3O | 293.37 | 2 / 0 | 2.3 | Yes |
| 76562 |  (S)-zacopride | C15H20ClN3O2 | 309.794 | 4 / 2 | 1.7 | Yes |
| 76574 |  Zacopride | C15H20ClN3O2 | 309.794 | 4 / 2 | 1.7 | Yes |
| 76586 |  (R)-zacopride | C15H20ClN3O2 | 309.794 | 4 / 2 | 1.7 | Yes |
| 77254 |  CHEMBL3093192 | C21H20F4N2O | 392.398 | 7 / 0 | 5.7 | No |
| 77260 |  SDZ-205557 | C14H21ClN2O3 | 300.783 | 5 / 1 | 3.2 | Yes |
| 77888 |  CHEMBL287299 | C21H28ClN3O | 373.925 | 4 / 1 | 5.2 | No |
| 77950 |  CHEMBL317146 | C19H29N5O2 | 359.474 | 4 / 1 | 2.1 | Yes |
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