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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	5-hydroxytryptamine receptor 4
Species	Cavia porcellus (Guinea pig)
Gene	HTR4
Synonym	5-HT-4 5-HT4 Serotonin receptor 4
Disease	N/A for non-human GPCRs
Length	388
Amino acid sequence	MDKLDANVSSKEGFGSVEKVVLLTFLSAVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWVYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHARQIQVLQRAGAPAEGRPQPADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQLWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRDTVECGGQWESQCHPAASSPLVAAQPIDT
UniProt	O70528
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5017
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL500336
Molecular formula	C16H19N3OS
IUPAC name	8-(2-piperidin-2-ylethoxy)-3-thia-1,7-diazatricyclo[7.3.0.02,6]dodeca-2(6),4,7,9,11-pentaene
Molecular weight	301.408
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	4.0
Synonyms	BDBM50413525
Inchi Key	DAKJEJKRHITXAV-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H19N3OS/c1-2-8-17-12(4-1)6-10-20-15-14-5-3-9-19(14)16-13(18-15)7-11-21-16/h3,5,7,9,11-12,17H,1-2,4,6,8,10H2
PubChem CID	44592039
ChEMBL	CHEMBL500336
IUPHAR	N/A
BindingDB	50413525
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Inhibition	5.0 %	PMID19261477	ChEMBL
Inhibition	90.0 %	PMID19261477	ChEMBL
Ki	616.6 nM	PMID19261477	BindingDB,ChEMBL

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