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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	5-hydroxytryptamine receptor 4
Species	Cavia porcellus (Guinea pig)
Gene	HTR4
Synonym	5-HT-4 5-HT4 Serotonin receptor 4
Disease	N/A for non-human GPCRs
Length	388
Amino acid sequence	MDKLDANVSSKEGFGSVEKVVLLTFLSAVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWVYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHARQIQVLQRAGAPAEGRPQPADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQLWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRDTVECGGQWESQCHPAASSPLVAAQPIDT
UniProt	O70528
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5017
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL471234
Molecular formula	C17H21N3OS
IUPAC name	8-(3-piperidin-1-ylpropoxy)-3-thia-1,7-diazatricyclo[7.3.0.02,6]dodeca-2(6),4,7,9,11-pentaene
Molecular weight	315.435
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	4.4
Synonyms	BDBM50413531
Inchi Key	ALQLSDCRWBIKMM-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H21N3OS/c1-2-8-19(9-3-1)10-5-12-21-16-15-6-4-11-20(15)17-14(18-16)7-13-22-17/h4,6-7,11,13H,1-3,5,8-10,12H2
PubChem CID	44592041
ChEMBL	CHEMBL471234
IUPHAR	N/A
BindingDB	50413531
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Inhibition	30.0 %	PMID19261477	ChEMBL
Inhibition	100.0 %	PMID19261477	ChEMBL
Ki	52.48 nM	PMID19261477	BindingDB,ChEMBL

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