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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	5-hydroxytryptamine receptor 4
Species	Cavia porcellus (Guinea pig)
Gene	HTR4
Synonym	5-HT-4 5-HT4 Serotonin receptor 4
Disease	N/A for non-human GPCRs
Length	388
Amino acid sequence	MDKLDANVSSKEGFGSVEKVVLLTFLSAVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWVYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHARQIQVLQRAGAPAEGRPQPADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQLWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRDTVECGGQWESQCHPAASSPLVAAQPIDT
UniProt	O70528
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5017
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL156088
Molecular formula	C17H24ClN2O3+
IUPAC name	2-(1-azoniabicyclo[2.2.2]octan-1-yl)ethyl 4-amino-5-chloro-2-methoxybenzoate
Molecular weight	339.84
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	2.6
Synonyms	BDBM50056409 1-[2-(4-Amino-5-chloro-2-methoxy-benzoyloxy)-ethyl]-1-azonia-bicyclo[2.2.2]octane
Inchi Key	CQOUHYDQTTXXBZ-UHFFFAOYSA-O
Inchi ID	InChI=1S/C17H23ClN2O3/c1-22-16-11-15(19)14(18)10-13(16)17(21)23-9-8-20-5-2-12(3-6-20)4-7-20/h10-12H,2-9H2,1H3,(H-,19,21)/p+1
PubChem CID	10764565
ChEMBL	CHEMBL156088
IUPHAR	N/A
BindingDB	50056409
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Activity	78.0 %	PMID9046352	ChEMBL
EC50	5.3 nM	PMID9046352	BindingDB,ChEMBL
IC50	20.0 nM	PMID9046352	ChEMBL

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