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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	5-hydroxytryptamine receptor 4
Species	Cavia porcellus (Guinea pig)
Gene	HTR4
Synonym	5-HT-4 5-HT4 Serotonin receptor 4
Disease	N/A for non-human GPCRs
Length	388
Amino acid sequence	MDKLDANVSSKEGFGSVEKVVLLTFLSAVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWVYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHARQIQVLQRAGAPAEGRPQPADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQLWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRDTVECGGQWESQCHPAASSPLVAAQPIDT
UniProt	O70528
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5017
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL426216
Molecular formula	C21H34ClN5O2
IUPAC name	4-amino-N-[1-[[1-(2-aminoethyl)piperidin-4-yl]methyl]piperidin-4-yl]-5-chloro-2-methoxybenzamide
Molecular weight	423.986
Hydrogen bond acceptor	6
Hydrogen bond donor	3
XlogP	1.6
Synonyms	BDBM50112036 N-[1-[1-(2-Aminoethyl)piperidine-4-ylmethyl]piperidine-4-yl]-2-methoxy-4-amino-5-chlorobenzamide 4-Amino-N-{1-[1-(2-amino-ethyl)-piperidin-4-ylmethyl]-piperidin-4-yl}-5-chloro-2-methoxy-benzamide
Inchi Key	DCUVLBUVWCWEND-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H34ClN5O2/c1-29-20-13-19(24)18(22)12-17(20)21(28)25-16-4-9-27(10-5-16)14-15-2-7-26(8-3-15)11-6-23/h12-13,15-16H,2-11,14,23-24H2,1H3,(H,25,28)
PubChem CID	44386218
ChEMBL	CHEMBL426216
IUPHAR	N/A
BindingDB	50112036
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	14.0 nM	PMID11959005	BindingDB
IC50	14.3 nM	PMID11959005	ChEMBL

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