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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	5-hydroxytryptamine receptor 4
Species	Cavia porcellus (Guinea pig)
Gene	HTR4
Synonym	5-HT-4 5-HT4 Serotonin receptor 4
Disease	N/A for non-human GPCRs
Length	388
Amino acid sequence	MDKLDANVSSKEGFGSVEKVVLLTFLSAVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWVYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHARQIQVLQRAGAPAEGRPQPADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQLWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRDTVECGGQWESQCHPAASSPLVAAQPIDT
UniProt	O70528
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5017
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL95661
Molecular formula	C20H29N5O2
IUPAC name	3-cyclopropyl-2-oxo-N-[2-(4-propylpiperazin-1-yl)ethyl]benzimidazole-1-carboxamide
Molecular weight	371.485
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	2.4
Synonyms	3-Cyclopropyl-N-[2-(4-propylpiperazino)ethyl]-2-oxo-2,3-dihydro-1H-benzimidazole-1-carboxamide 3-Cyclopropyl-2-oxo-2,3-dihydro-benzoimidazole-1-carboxylic acid [2-(4-propyl-piperazin-1-yl)-ethyl]-amide BDBM50079297
Inchi Key	AKWCUHYNOGZWTQ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H29N5O2/c1-2-10-22-12-14-23(15-13-22)11-9-21-19(26)25-18-6-4-3-5-17(18)24(20(25)27)16-7-8-16/h3-6,16H,2,7-15H2,1H3,(H,21,26)
PubChem CID	11726706
ChEMBL	CHEMBL95661
IUPHAR	N/A
BindingDB	50079297
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Intrinsic activity	0.41 -	PMID10425096	ChEMBL
Ki	8.2 nM	PMID10425096	BindingDB,ChEMBL
pKb	7.46 -	PMID10425096	ChEMBL

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