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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	5-hydroxytryptamine receptor 4
Species	Cavia porcellus (Guinea pig)
Gene	HTR4
Synonym	5-HT-4 5-HT4 Serotonin receptor 4
Disease	N/A for non-human GPCRs
Length	388
Amino acid sequence	MDKLDANVSSKEGFGSVEKVVLLTFLSAVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWVYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHARQIQVLQRAGAPAEGRPQPADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQLWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRDTVECGGQWESQCHPAASSPLVAAQPIDT
UniProt	O70528
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5017
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL2440451
Molecular formula	C22H31N3O3
IUPAC name	N-[(1-butylpiperidin-4-yl)methyl]-7-hydroxy-3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carboxamide
Molecular weight	385.508
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	3.3
Synonyms	BDBM50442805
Inchi Key	BBTVQUWEONDCQJ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H31N3O3/c1-2-3-9-24-11-7-16(8-12-24)15-23-21(27)20-18-6-5-17(26)14-19(18)25-10-4-13-28-22(20)25/h5-6,14,16,26H,2-4,7-13,15H2,1H3,(H,23,27)
PubChem CID	73354085
ChEMBL	CHEMBL2440451
IUPHAR	N/A
BindingDB	50442805
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	794.0 nM	PMID24113240	BindingDB
Ki	794.33 nM	PMID24113240	ChEMBL

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