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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	5-hydroxytryptamine receptor 4
Species	Cavia porcellus (Guinea pig)
Gene	HTR4
Synonym	5-HT-4 5-HT4 Serotonin receptor 4
Disease	N/A for non-human GPCRs
Length	388
Amino acid sequence	MDKLDANVSSKEGFGSVEKVVLLTFLSAVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWVYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHARQIQVLQRAGAPAEGRPQPADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQLWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRDTVECGGQWESQCHPAASSPLVAAQPIDT
UniProt	O70528
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5017
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL35972
Molecular formula	C19H25N3O
IUPAC name	5-[(1-methylpiperidin-4-yl)methoxy]-1,2,3,4-tetrahydrobenzo[h][1,6]naphthyridine
Molecular weight	311.429
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	3.7
Synonyms	6-(1-Methylpiperidine-4-ylmethoxy)-7,8,9,10-tetrahydro-10-azabenzo[c]quinoline 9-Methyl-5-(piperidin-4-ylmethoxy)-1,2,3,4-tetrahydro-benzo[h][1,6]naphthyridine BDBM50122717
Inchi Key	FEJCPBJPOXKMKM-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H25N3O/c1-22-11-8-14(9-12-22)13-23-19-16-6-4-10-20-18(16)15-5-2-3-7-17(15)21-19/h2-3,5,7,14,20H,4,6,8-13H2,1H3
PubChem CID	9857899
ChEMBL	CHEMBL35972
IUPHAR	N/A
BindingDB	50122717
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Inhibition	52.0 %	PMID12502367	ChEMBL
Inhibition	100.0 %	PMID12502367	ChEMBL
Ki	79.7 nM	PMID12502367	ChEMBL
Ki	80.0 nM	PMID12502367	BindingDB

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