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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	5-hydroxytryptamine receptor 4
Species	Cavia porcellus (Guinea pig)
Gene	HTR4
Synonym	5-HT-4 5-HT4 Serotonin receptor 4
Disease	N/A for non-human GPCRs
Length	388
Amino acid sequence	MDKLDANVSSKEGFGSVEKVVLLTFLSAVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWVYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHARQIQVLQRAGAPAEGRPQPADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQLWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRDTVECGGQWESQCHPAASSPLVAAQPIDT
UniProt	O70528
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5017
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL156348
Molecular formula	C17H24ClN3O4
IUPAC name	2-(4-acetamidopiperidin-1-yl)ethyl 4-amino-5-chloro-2-methoxybenzoate
Molecular weight	369.846
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	1.6
Synonyms	BDBM50056416 SCHEMBL9117930 4-Amino-5-chloro-2-methoxy-benzoic acid 2-(4-acetylamino-piperidin-1-yl)-ethyl ester
Inchi Key	DEKWIDJXEYNIHF-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H24ClN3O4/c1-11(22)20-12-3-5-21(6-4-12)7-8-25-17(23)13-9-14(18)15(19)10-16(13)24-2/h9-10,12H,3-8,19H2,1-2H3,(H,20,22)
PubChem CID	10690483
ChEMBL	CHEMBL156348
IUPHAR	N/A
BindingDB	50056416
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Activity	59.0 %	PMID9046352	ChEMBL
EC50	13.0 nM	PMID9046352	BindingDB,ChEMBL

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