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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	5-hydroxytryptamine receptor 4
Species	Cavia porcellus (Guinea pig)
Gene	HTR4
Synonym	5-HT-4 5-HT4 Serotonin receptor 4
Disease	N/A for non-human GPCRs
Length	388
Amino acid sequence	MDKLDANVSSKEGFGSVEKVVLLTFLSAVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWVYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHARQIQVLQRAGAPAEGRPQPADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQLWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRDTVECGGQWESQCHPAASSPLVAAQPIDT
UniProt	O70528
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5017
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL2181185
Molecular formula	C22H25FN2O
IUPAC name	3-fluoro-6-[(1-propylpiperidin-4-yl)methoxy]phenanthridine
Molecular weight	352.453
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	5.5
Synonyms	BDBM50399618
Inchi Key	DBUWXKOGBDPUGP-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H25FN2O/c1-2-11-25-12-9-16(10-13-25)15-26-22-20-6-4-3-5-18(20)19-8-7-17(23)14-21(19)24-22/h3-8,14,16H,2,9-13,15H2,1H3
PubChem CID	71461048
ChEMBL	CHEMBL2181185
IUPHAR	N/A
BindingDB	50399618
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Inhibition	14.0 %	PMID23102207	ChEMBL
Inhibition	100.0 %	PMID23102207	ChEMBL
Ki	101.0 nM	PMID23102207	BindingDB,ChEMBL

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