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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	5-hydroxytryptamine receptor 4
Species	Cavia porcellus (Guinea pig)
Gene	HTR4
Synonym	5-HT-4 5-HT4 Serotonin receptor 4
Disease	N/A for non-human GPCRs
Length	388
Amino acid sequence	MDKLDANVSSKEGFGSVEKVVLLTFLSAVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWVYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHARQIQVLQRAGAPAEGRPQPADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQLWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRDTVECGGQWESQCHPAASSPLVAAQPIDT
UniProt	O70528
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5017
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL76552
Molecular formula	C18H27N5O
IUPAC name	1-heptyl-2-[(E)-(5-hydroxy-1H-indol-3-yl)methylideneamino]-1-methylguanidine
Molecular weight	329.448
Hydrogen bond acceptor	3
Hydrogen bond donor	3
XlogP	3.7
Synonyms	SCHEMBL7384184
Inchi Key	BCUWYGBYMHYDRM-FYJGNVAPSA-N
Inchi ID	InChI=1S/C18H27N5O/c1-3-4-5-6-7-10-23(2)18(19)22-21-13-14-12-20-17-9-8-15(24)11-16(14)17/h8-9,11-13,20,24H,3-7,10H2,1-2H3,(H2,19,22)/b21-13+
PubChem CID	135516796
ChEMBL	CHEMBL76552
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
pD2	8.0 -	PMID7608899	ChEMBL
Relative efficacy	1.6 -	PMID7608899	ChEMBL

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