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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	5-hydroxytryptamine receptor 4
Species	Cavia porcellus (Guinea pig)
Gene	HTR4
Synonym	5-HT-4 5-HT4 Serotonin receptor 4
Disease	N/A for non-human GPCRs
Length	388
Amino acid sequence	MDKLDANVSSKEGFGSVEKVVLLTFLSAVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWVYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHARQIQVLQRAGAPAEGRPQPADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQLWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRDTVECGGQWESQCHPAASSPLVAAQPIDT
UniProt	O70528
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5017
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL2181190
Molecular formula	C22H25FN2O
IUPAC name	7-fluoro-6-[(1-propylpiperidin-4-yl)methoxy]phenanthridine
Molecular weight	352.453
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	5.5
Synonyms	BDBM50399633
Inchi Key	ADONYAJEPBCRAQ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H25FN2O/c1-2-12-25-13-10-16(11-14-25)15-26-22-21-18(7-5-8-19(21)23)17-6-3-4-9-20(17)24-22/h3-9,16H,2,10-15H2,1H3
PubChem CID	71462781
ChEMBL	CHEMBL2181190
IUPHAR	N/A
BindingDB	50399633
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Inhibition	0.0 %	PMID23102207	ChEMBL
Inhibition	100.0 %	PMID23102207	ChEMBL
Ki	21.6 nM	PMID23102207	BindingDB,ChEMBL

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