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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	5-hydroxytryptamine receptor 4
Species	Cavia porcellus (Guinea pig)
Gene	HTR4
Synonym	5-HT-4 5-HT4 Serotonin receptor 4
Disease	N/A for non-human GPCRs
Length	388
Amino acid sequence	MDKLDANVSSKEGFGSVEKVVLLTFLSAVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWVYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHARQIQVLQRAGAPAEGRPQPADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQLWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRDTVECGGQWESQCHPAASSPLVAAQPIDT
UniProt	O70528
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5017
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL142687
Molecular formula	C14H16ClN5OS
IUPAC name	4-amino-N-(1-azabicyclo[2.2.2]octan-3-yl)-5-chloro-2,1,3-benzothiadiazole-7-carboxamide
Molecular weight	337.826
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	1.6
Synonyms	BDBM50449632
Inchi Key	DNQOMGGYJRBLOX-UHFFFAOYSA-N
Inchi ID	InChI=1S/C14H16ClN5OS/c15-9-5-8(12-13(11(9)16)19-22-18-12)14(21)17-10-6-20-3-1-7(10)2-4-20/h5,7,10H,1-4,6,16H2,(H,17,21)
PubChem CID	15681450
ChEMBL	CHEMBL142687
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
pD2	5.5 -	Bioorg. Med. Chem. Lett., (1992) 2:5:461	ChEMBL
pD2	5.8 -	Bioorg. Med. Chem. Lett., (1992) 2:5:461	ChEMBL

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