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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	5-hydroxytryptamine receptor 4
Species	Cavia porcellus (Guinea pig)
Gene	HTR4
Synonym	5-HT-4 5-HT4 Serotonin receptor 4
Disease	N/A for non-human GPCRs
Length	388
Amino acid sequence	MDKLDANVSSKEGFGSVEKVVLLTFLSAVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWVYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHARQIQVLQRAGAPAEGRPQPADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQLWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRDTVECGGQWESQCHPAASSPLVAAQPIDT
UniProt	O70528
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5017
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL363466
Molecular formula	C20H25NO2
IUPAC name	(2S)-5-(2,6-dimethoxyphenyl)-N,N-dimethyl-1,2,3,4-tetrahydronaphthalen-2-amine
Molecular weight	311.425
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	4.2
Synonyms	BDBM50150673 (3S)-3alpha-(Dimethylamino)-8-(2,6-dimethoxyphenyl)tetralin
Inchi Key	BFHVQDBLFZYJPG-HNNXBMFYSA-N
Inchi ID	InChI=1S/C20H25NO2/c1-21(2)15-11-12-16-14(13-15)7-5-8-17(16)20-18(22-3)9-6-10-19(20)23-4/h5-10,15H,11-13H2,1-4H3/t15-/m0/s1
PubChem CID	10064052
ChEMBL	CHEMBL363466
IUPHAR	N/A
BindingDB	50150673
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<1000.0 nM	PMID15267230	BindingDB,ChEMBL

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