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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	5-hydroxytryptamine receptor 4
Species	Cavia porcellus (Guinea pig)
Gene	HTR4
Synonym	5-HT-4 5-HT4 Serotonin receptor 4
Disease	N/A for non-human GPCRs
Length	388
Amino acid sequence	MDKLDANVSSKEGFGSVEKVVLLTFLSAVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWVYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHARQIQVLQRAGAPAEGRPQPADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQLWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRDTVECGGQWESQCHPAASSPLVAAQPIDT
UniProt	O70528
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5017
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL140153
Molecular formula	C15H22ClN3O
IUPAC name	6-amino-7-chloro-2-[2-(diethylamino)ethyl]-3,4-dihydroisoquinolin-1-one
Molecular weight	295.811
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	2.1
Synonyms	N/A
Inchi Key	DKSYICLASPUIME-UHFFFAOYSA-N
Inchi ID	InChI=1S/C15H22ClN3O/c1-3-18(4-2)7-8-19-6-5-11-9-14(17)13(16)10-12(11)15(19)20/h9-10H,3-8,17H2,1-2H3
PubChem CID	15681439
ChEMBL	CHEMBL140153
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
pD2	5.1 -	Bioorg. Med. Chem. Lett., (1992) 2:5:461	ChEMBL
pD2	5.2 -	Bioorg. Med. Chem. Lett., (1992) 2:5:461	ChEMBL

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