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| Name | Metabotropic glutamate receptor 8 |
|---|---|
| Species | Homo sapiens (Human) |
| Gene | GRM8 |
| Synonym | mGluR8b mGluR8 mGlu8 receptor Gprc1h glutamate receptor [ Show all ] |
| Disease | N/A |
| Length | 908 |
| Amino acid sequence | MVCEGKRSASCPCFFLLTAKFYWILTMMQRTHSQEYAHSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQLHLKVEDMQWAHREHTHPASVCSLPCKPGERKKTVKGVPCCWHCERCEGYNYQVDELSCELCPLDQRPNMNRTGCQLIPIIKLEWHSPWAVVPVFVAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFLMIAAPDTIICSFRRVFLGLGMCFSYAALLTKTNRIHRIFEQGKKSVTAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPHIIIDYGEQRTLDPEKARGVLKCDISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQKRKRSFKAVVTAATMQSKLIQKGNDRPNGEVKSELCESLETNTSSTKTTYISYSNHSI |
| UniProt | O00222 |
| Protein Data Bank | 6bsz, 6bt5, 6e5v |
| GPCR-HGmod model | N/A |
| 3D structure model | This structure is from PDB ID 6bsz. |
| BioLiP | BL0432251,BL0432252, BL0403876,BL0403877, BL0403874,BL0403875 |
| Therapeutic Target Database | N/A |
| ChEMBL | CHEMBL3228 |
| IUPHAR | 296 |
| DrugBank | BE0000835 |
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| GLASS ID | Molecule | Formula | Molecular weight | H-bond acceptor / donor | XlogP | Lipinski's druglikeness |
|---|---|---|---|---|---|---|
| 4946 |  CHEMBL1099113 | C23H16N2 | 320.395 | 2 / 0 | 5.6 | No |
| 536142 |  CHEMBL3899832 | C22H19N5O4 | 417.425 | 8 / 2 | 3.6 | Yes |
| 8263 |  CHEMBL2208408 | C15H15ClN2O3S | 338.806 | 4 / 1 | 2.6 | Yes |
| 10400 |  CHEMBL2426616 | C14H14N2O2S | 274.338 | 4 / 0 | 2.3 | Yes |
| 11485 |  CHEMBL2381648 | C10H14N2O5 | 242.231 | 6 / 4 | -4.2 | Yes |
| 11489 |  CHEMBL2381649 | C10H14N2O5 | 242.231 | 6 / 4 | -4.2 | Yes |
| 12903 |  VU 0361737 | C13H11ClN2O2 | 262.693 | 3 / 1 | 2.6 | Yes |
| 15206 |  635318-11-5 | C7H9NO6S | 235.21 | 7 / 3 | -4.8 | Yes |
| 16003 |  CHEMBL300330 | C7H12N2O4 | 188.183 | 6 / 3 | -6.0 | Yes |
| 20311 |  CHEMBL319279 | C28H27NO5 | 457.526 | 6 / 3 | 2.1 | Yes |
| 465374 |  AC1N2AWG | C24H24N2O4S | 436.526 | 5 / 1 | 4.1 | Yes |
| 24452 |  CHEMBL2381647 | C8H12N2O4 | 200.194 | 6 / 4 | -6.7 | Yes |
| 24454 |  CHEMBL2381646 | C8H12N2O4 | 200.194 | 6 / 4 | -6.7 | Yes |
| 30709 |  CHEMBL365368 | C9H13NO4 | 199.206 | 5 / 3 | -2.8 | Yes |
| 30712 |  LY 395756 | C9H13NO4 | 199.206 | 5 / 3 | -2.8 | Yes |
| 466688 |  CHEMBL3560146 | C24H24N2O5 | 420.465 | 5 / 1 | 3.5 | Yes |
| 35424 |  CHEMBL418462 | C13H15ClN2O4 | 298.723 | 6 / 3 | -3.9 | Yes |
| 35744 |  CHEMBL1099112 | C17H11ClN2 | 278.739 | 2 / 0 | 4.6 | Yes |
| 35791 |  BDBM50388941 | C16H13N3O3 | 295.298 | 5 / 1 | 1.4 | Yes |
| 553429 |  CID 57689797 | C3H8NO6P | 185.072 | 6 / 3 | -4.5 | Yes |
| 467495 |  CHEMBL3605296 | C20H17N5O3 | 375.388 | 6 / 1 | 2.1 | Yes |
| 522877 |  CHEMBL3746457 | C18H15FN4O2 | 338.342 | 5 / 0 | 2.2 | Yes |
| 48295 |  CHEMBL180822 | C7H11NO5 | 189.167 | 6 / 4 | -4.2 | Yes |
| 469265 |  CHEMBL3628115 | C19H12ClN3O4 | 381.772 | 5 / 1 | 2.6 | Yes |
| 53138 |  CHEMBL1688377 | C18H25N3OS | 331.478 | 4 / 0 | 3.3 | Yes |
| 469948 |  CHEMBL3628112 | C20H12Cl2N2O4 | 415.226 | 4 / 1 | 4.3 | Yes |
| 553523 |  D-AP4 | C4H10NO5P | 183.1 | 6 / 4 | -5.5 | Yes |
| 57275 |  2-amino-4-phosphonobutanoic acid | C4H10NO5P | 183.1 | 6 / 4 | -5.5 | Yes |
| 57295 |  L-AP4 | C4H10NO5P | 183.1 | 6 / 4 | -5.5 | Yes |
| 61030 |  CHEMBL1099115 | C22H15N3 | 321.383 | 3 / 0 | 4.5 | Yes |
| 61163 |  CHEMBL334014 | C8H10FNO4 | 203.169 | 6 / 3 | -3.2 | Yes |
| 470950 |  CHEMBL3560746 | C23H25NO3S | 395.517 | 4 / 0 | 5.4 | No |
| 471017 |  CHEMBL3561387 | C23H23F2NO3S | 431.498 | 6 / 0 | 5.9 | No |
| 70061 |  CHEMBL541754 | C13H10F2N2O2 | 264.232 | 5 / 1 | 2.9 | Yes |
| 70678 |  LY307452 | C21H25NO4 | 355.434 | 5 / 3 | 1.4 | Yes |
| 75319 |  CHEMBL1096196 | C16H10ClN3 | 279.727 | 3 / 0 | 3.8 | Yes |
| 79208 |  BDBM86213 | C13H13NO4 | 247.25 | 5 / 0 | 1.5 | Yes |
| 80655 |  CHEMBL1783985 | C15H25NO | 235.371 | 1 / 0 | 3.4 | Yes |
| 473324 |  CHEMBL3561819 | C24H25NO3S | 407.528 | 4 / 0 | 5.2 | No |
| 89472 |  CPCCOEt | C13H13NO4 | 247.25 | 5 / 1 | 1.9 | Yes |
| 95885 |  CHEMBL1098805 | C22H16N2OS | 356.443 | 4 / 0 | 5.6 | No |
| 474765 |  CHEMBL3560922 | C24H23NO6 | 421.449 | 6 / 0 | 4.1 | Yes |
| 96475 |  2-(m-tolylethynyl)pyrimidine | C13H10N2 | 194.237 | 2 / 0 | 2.6 | Yes |
| 553774 |  D0N9UZ | C12H13N5O6 | 323.265 | 8 / 5 | -4.7 | Yes |
| 107852 |  CHEMBL1098212 | C16H9F3N2O3S2 | 398.374 | 9 / 0 | 4.9 | Yes |
| 109306 |  (2S,1'S,2'S)-2-(carboxycyclopropyl)glycine | C6H9NO4 | 159.141 | 5 / 3 | -3.4 | Yes |
| 477081 |  CHEMBL3628113 | C20H12ClFN2O4 | 398.774 | 5 / 1 | 3.8 | Yes |
| 524872 |  CHEMBL3804846 | C22H14F2N2O2 | 376.363 | 5 / 1 | 3.9 | Yes |
| 119805 |  CHEMBL319732 | C26H31NO5 | 437.536 | 6 / 3 | 2.9 | Yes |
| 120197 |  CHEMBL1096811 | C19H16N2O2 | 304.349 | 4 / 0 | 3.9 | Yes |
| 120219 |  CHEBI:75204 | C8H9NO4 | 183.163 | 4 / 3 | -1.8 | Yes |
| 130835 |  CHEMBL59830 | C8H14N2O4 | 202.21 | 6 / 3 | -5.7 | Yes |
| 133593 |  CHEMBL61281 | C17H18N2O4 | 314.341 | 6 / 3 | -3.3 | Yes |
| 553955 |  (S)-3,4-DCPG | C10H9NO6 | 239.183 | 7 / 4 | -2.7 | Yes |
| 137460 |  CHEMBL1098228 | C24H18N2O | 350.421 | 3 / 0 | 5.4 | No |
| 480599 |  AC1P03JT | C18H22N2O2S | 330.446 | 3 / 1 | 2.9 | Yes |
| 151149 |  CHEMBL420262 | C29H37NO5 | 479.617 | 6 / 3 | 4.5 | Yes |
| 482195 |  CHEMBL3561545 | C22H21FN2O2S | 396.48 | 4 / 1 | 4.3 | Yes |
| 158296 |  (RS)-PPG | C8H10NO5P | 231.144 | 6 / 4 | -3.7 | Yes |
| 482581 |  CHEMBL3561788 | C20H21N3O2S2 | 399.527 | 5 / 1 | 4.0 | Yes |
| 164081 |  CHEMBL1096844 | C20H12N2S | 312.39 | 3 / 0 | 5.3 | No |
| 171715 |  DFMTI | C20H18F2N4O | 368.388 | 5 / 0 | 3.4 | Yes |
| 179638 |  CHEMBL304919 | C20H22N2O4 | 354.406 | 6 / 3 | -2.6 | Yes |
| 486354 |  CHEMBL3561539 | C22H21F2NO3S | 417.471 | 6 / 0 | 5.9 | No |
| 563359 |  SIB 1757 | C12H11N3O | 213.24 | 4 / 1 | 3.0 | Yes |
| 192707 |  CHEMBL1682820 | C16H14O3 | 254.285 | 3 / 0 | 2.8 | Yes |
| 195663 |  CHEMBL40123 | C19H21NO4 | 327.38 | 5 / 3 | 0.3 | Yes |
| 563499 |  CHEMBL1098211 | C17H12N2O | 260.296 | 3 / 1 | 4.1 | Yes |
| 197760 |  3-((2-fluorothiazol-4-yl)ethynyl)-5-fluorobenzonitrile | C12H4F2N2S | 246.235 | 5 / 0 | 3.3 | Yes |
| 199211 |  1-Benzyl-APDC | C13H16N2O4 | 264.281 | 6 / 3 | -4.5 | Yes |
| 201016 |  Dcg-IV | C7H9NO6 | 203.15 | 7 / 4 | -4.3 | Yes |
| 488357 |  CHEMBL3560239 | C24H25NO4S | 423.527 | 5 / 0 | 4.8 | Yes |
| 488363 |  MLS000335684 | C22H21FN2O2S | 396.48 | 4 / 1 | 4.3 | Yes |
| 208549 |  7-(benzyloxy)-2,3-dihydro-4H-chromen-4-one | C16H14O3 | 254.285 | 3 / 0 | 2.8 | Yes |
| 489703 |  AC1N0VGZ | C21H26N2O3S | 386.51 | 4 / 1 | 2.9 | Yes |
| 490017 |  CHEMBL3561870 | C25H26N2O4S | 450.553 | 5 / 0 | 4.3 | Yes |
| 218682 |  CID 70682300 | C16H13N3O3 | 295.298 | 5 / 2 | 1.8 | Yes |
| 218948 |  CHEMBL439775 | C22H23NO5 | 381.428 | 6 / 3 | 0.7 | Yes |
| 219329 |  CHEMBL1682821 | C16H12O4 | 268.268 | 4 / 0 | 2.8 | Yes |
| 221358 |  CHEMBL1096197 | C22H15N3 | 321.383 | 3 / 0 | 4.5 | Yes |
| 221645 |  MPEP | C14H11N | 193.249 | 1 / 0 | 3.3 | Yes |
| 450600 |  CHEMBL3401195 | C19H16FN3O2 | 337.354 | 4 / 0 | 3.1 | Yes |
| 229984 |  MTEP | C11H8N2S | 200.259 | 3 / 0 | 2.3 | Yes |
| 231775 |  CHEMBL330097 | C8H11NO5 | 201.178 | 6 / 4 | -3.7 | Yes |
| 556397 |  Salvinorin A | C23H28O8 | 432.469 | 8 / 0 | 2.5 | Yes |
| 237338 |  AC1N0WBK | C23H28O8 | 432.469 | 8 / 0 | 2.5 | Yes |
| 237367 |  CHEMBL2381645 | C8H10N4O4 | 226.192 | 7 / 3 | -2.7 | Yes |
| 237371 |  CHEMBL2381644 | C8H10N4O4 | 226.192 | 7 / 3 | -2.7 | Yes |
| 492625 |  CHEMBL3560612 | C23H22F2N2O4 | 428.436 | 6 / 1 | 4.6 | Yes |
| 246419 |  CHEMBL2381641 | C9H11NO4 | 197.19 | 5 / 3 | -3.4 | Yes |
| 554538 |  MPPG | C9H12NO5P | 245.171 | 6 / 4 | -3.5 | Yes |
| 255963 |  AZD-6538 | C15H6FN5O | 291.245 | 7 / 0 | 2.0 | Yes |
| 261857 |  CHEMBL60008 | C13H15ClN2O4 | 298.723 | 6 / 3 | -3.9 | Yes |
| 266667 |  CHEMBL1099114 | C23H15FN2 | 338.385 | 3 / 0 | 5.7 | No |
| 529238 |  CHEMBL3747116 | C19H16FN3O2 | 337.354 | 4 / 0 | 3.2 | Yes |
| 271864 |  CHEMBL218710 | C7H9NO5S | 219.211 | 7 / 3 | -5.1 | Yes |
| 273369 |  CHEMBL302411 | C17H18N2O4 | 314.341 | 6 / 3 | -3.3 | Yes |
| 274092 |  CHEMBL8839 | C7H9NO4S | 203.212 | 6 / 3 | -3.5 | Yes |
| 274094 |  CHEMBL88999 | C7H9NO4S | 203.212 | 6 / 3 | -3.5 | Yes |
| 275155 |  CHEMBL244585 | C15H10N2S | 250.319 | 3 / 0 | 4.1 | Yes |
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