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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Metabotropic glutamate receptor 8
Species	Homo sapiens (Human)
Gene	GRM8
Synonym	mGluR8b mGluR8 mGlu8 receptor Gprc1h glutamate receptor GLUR8 [ Show all ]
Disease	N/A
Length	908
Amino acid sequence	MVCEGKRSASCPCFFLLTAKFYWILTMMQRTHSQEYAHSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQLHLKVEDMQWAHREHTHPASVCSLPCKPGERKKTVKGVPCCWHCERCEGYNYQVDELSCELCPLDQRPNMNRTGCQLIPIIKLEWHSPWAVVPVFVAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFLMIAAPDTIICSFRRVFLGLGMCFSYAALLTKTNRIHRIFEQGKKSVTAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPHIIIDYGEQRTLDPEKARGVLKCDISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQKRKRSFKAVVTAATMQSKLIQKGNDRPNGEVKSELCESLETNTSSTKTTYISYSNHSI
UniProt	O00222
Protein Data Bank	6bsz, 6bt5, 6e5v
GPCR-HGmod model	N/A
3D structure model	This structure is from PDB ID 6bsz.
BioLiP	BL0432251,BL0432252, BL0403876,BL0403877, BL0403874,BL0403875
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3228
IUPHAR	296
DrugBank	BE0000835

Ligand

Name	7-(benzyloxy)-2,3-dihydro-4H-chromen-4-one
Molecular formula	C16H14O3
IUPAC name	7-phenylmethoxy-2,3-dihydrochromen-4-one
Molecular weight	254.285
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	2.8
Synonyms	31042-20-3 7-phenylmethoxy-2,3-dihydrochromen-4-one cid_4521898 ZINC4656472 7-(Benzyloxy)-2,3-dihydro-4H-1-benzopyran-4-one AC1Q6ESN MCULE-4867351823 7-benzoxychroman-4-one SCHEMBL2326572 7-phenylmethoxy-3,4-dihydro-2H-1-benzopyran-4-one HMS2394K09 AKOS015899237 MLQFOEOUNIRULR-UHFFFAOYSA-N 7-benzyloxychroman-4-one CHEMBL1348198 SMR000115170 4H-1-Benzopyran-4-one, 2,3-dihydro-7-(phenylmethoxy)- AC1ND3YY I14-12195 7-(benzyloxy)-3,4-dihydro-2H-1-benzopyran-4-one BDBM49388 MLS000594478 [ Show all ]
Inchi Key	MLQFOEOUNIRULR-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H14O3/c17-15-8-9-18-16-10-13(6-7-14(15)16)19-11-12-4-2-1-3-5-12/h1-7,10H,8-9,11H2
PubChem CID	4521898
ChEMBL	CHEMBL1348198
IUPHAR	N/A
BindingDB	49388
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	<10000.0 nM	PMID23947773	BindingDB,ChEMBL

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