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GPCR

NameMetabotropic glutamate receptor 8
SpeciesHomo sapiens (Human)
GeneGRM8
SynonymmGluR8b
mGluR8
mGlu8 receptor
Gprc1h
glutamate receptor
[ Show all ]
DiseaseN/A
Length908
Amino acid sequenceMVCEGKRSASCPCFFLLTAKFYWILTMMQRTHSQEYAHSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQLHLKVEDMQWAHREHTHPASVCSLPCKPGERKKTVKGVPCCWHCERCEGYNYQVDELSCELCPLDQRPNMNRTGCQLIPIIKLEWHSPWAVVPVFVAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFLMIAAPDTIICSFRRVFLGLGMCFSYAALLTKTNRIHRIFEQGKKSVTAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPHIIIDYGEQRTLDPEKARGVLKCDISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQKRKRSFKAVVTAATMQSKLIQKGNDRPNGEVKSELCESLETNTSSTKTTYISYSNHSI
UniProtO00222
Protein Data Bank6bsz, 6bt5, 6e5v
GPCR-HGmod modelN/A
3D structure modelThis structure is from PDB ID 6bsz.
BioLiPBL0432251,BL0432252, BL0403876,BL0403877, BL0403874,BL0403875
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3228
IUPHAR296
DrugBankBE0000835

Ligand

NameCID 70682300
Molecular formulaC16H13N3O3
IUPAC name(1aS,7E,7aS)-7-hydroxyimino-N-pyridin-2-yl-1,7a-dihydrocyclopropa[b]chromene-1a-carboxamide
Molecular weight295.298
Hydrogen bond acceptor5
Hydrogen bond donor2
XlogP1.8
SynonymsN/A
Inchi KeyNAPZSTOOVHXHKA-UPDNOGQMSA-N
Inchi IDInChI=1S/C16H13N3O3/c20-15(18-13-7-3-4-8-17-13)16-9-11(16)14(19-21)10-5-1-2-6-12(10)22-16/h1-8,11,21H,9H2,(H,17,18,20)/b19-14-/t11-,16-/m0/s1
PubChem CID70682300
ChEMBLCHEMBL2063423
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC50<30000.0 nMPMID22148748ChEMBL

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