Zhang Lab

National University of Singapore

Home Research COVID-19 Services Publications People Teaching Job Opening News Forum Lab Only

Online Services

●I-TASSER ●I-TASSER-MTD ●C-I-TASSER ●CR-I-TASSER ●QUARK ●C-QUARK ●LOMETS ●MUSTER ●CEthreader ●SEGMER ●DeepFold ●DeepFoldRNA ●FoldDesign ●COFACTOR ●COACH ●MetaGO ●TripletGO ●IonCom ●FG-MD ●ModRefiner ●REMO ●DEMO ●DEMO-EM ●SPRING ●COTH ●Threpp ●PEPPI ●BSpred ●ANGLOR ●EDock ●BSP-SLIM ●SAXSTER ●FUpred ●ThreaDom ●ThreaDomEx ●EvoDesign ●BindProf ●BindProfX ●SSIPe ●GPCR-I-TASSER ●MAGELLAN ●ResQ ●STRUM ●DAMpred

●TM-score ●TM-align ●US-align ●MM-align ●RNA-align ●NW-align ●LS-align ●EDTSurf ●MVP ●MVP-Fit ●SPICKER ●HAAD ●PSSpred ●3DRobot ●MR-REX ●I-TASSER-MR ●SVMSEQ ●NeBcon ●ResPRE ●TripletRes ●DeepPotential ●WDL-RF ●ATPbind ●DockRMSD ●DeepMSA ●FASPR ●EM-Refiner ●GPU-I-TASSER

●BioLiP ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●Tara-3D ●TM-fold ●DECOYS ●POTENTIAL ●RW/RWplus ●EvoEF ●HPSF ●THE-DB ●ADDRESS ●Alpaca-Antibody ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12 ●CASP13 ●CASP14

GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	L-AP4
Molecular formula	C4H10NO5P
IUPAC name	(2S)-2-amino-4-phosphonobutanoic acid
Molecular weight	183.1
Hydrogen bond acceptor	6
Hydrogen bond donor	4
XlogP	-5.5
Synonyms	NCI30079 Tocris-0103 B6200 CHEMBL33567 GTPL1410 L-(+)-2-Amino-4-phosphonobutyric acid, optical purity optical purity: >=95% (HPLC, Marfey's reagent) M01257 NSC-30079 [3H]AP4 (2S)-2-amino-4-phosphonobutanoic acid 23052-81-5 BN0084 D0H7UP J-014961 L-2-amino-4-phosphonobutiric acid NCGC00013365 NCGC00024468-01 SR-01000597692 (S)-2-amino-4-phosphonobutanoic acid ACM23052815 CCG-37553 FCH919870 L-(+)-2-Amino-4-phosphono-butanoic acid L-APB NCIStruc1_000162 UNII-H8B59H10OK component DDOQBQRIEWHWBT-VKHMYHEASA-N 2-Amino-3-(3,5-dioxo-[1,2,4]oxadiazolidin-2-yl)-propionic acid B6202 CS-0020419 GTPL1412 L-1-amino-4-phosphonobutanoic acid MFCD00083244 S-2-amino-4-phosphonobutyrate (2S)-2-amino-4-phosphonobutanoic acid. Butanoic acid,2-amino-4-phosphono-,(2S)- D0PN6Z l(+)-2-amino-4-phosphonobutanoic acid L-AP-4 NCGC00013365-02 NCGC00024468-02 SR-01000597692-1 AKOS006239562 FT-0689296 L-(+)-2-Amino-4-phosphonobutyric acid LS-46098 NCIStruc2_000128 ZINC2033983 2-Amino-4-phosphono-butyric acid(S-AP4) BDBM50007548 D08PBE HY-100781A L-150 MolPort-002-514-399 SCHEMBL1969235 (S)-2-Amino-4-phosphono-butyric acid AC1L456H C-55169 E7P L(+)-2-Amino-4-phosphonobutanoic acid (L-AP4) NCGC00013365-03 [ Show all ]
Inchi Key	DDOQBQRIEWHWBT-VKHMYHEASA-N
Inchi ID	InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)/t3-/m0/s1
PubChem CID	179394
ChEMBL	CHEMBL33567
IUPHAR	1412, 1410
BindingDB	50007548
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
57292	Metabotropic glutamate receptor 1	Q13255	GRM1	Homo sapiens (Human)	1194
57293	Metabotropic glutamate receptor 1	P23385	Grm1	Rattus norvegicus (Rat)	1199
57284	Metabotropic glutamate receptor 2	P31421	Grm2	Rattus norvegicus (Rat)	872
57288	Metabotropic glutamate receptor 2	Q14416	GRM2	Homo sapiens (Human)	872
57286	Metabotropic glutamate receptor 3	P31422	Grm3	Rattus norvegicus (Rat)	879
57287	Metabotropic glutamate receptor 3	Q14832	GRM3	Homo sapiens (Human)	879
57285	Metabotropic glutamate receptor 4	P31423	Grm4	Rattus norvegicus (Rat)	912
57289	Metabotropic glutamate receptor 4	Q14833	GRM4	Homo sapiens (Human)	912
57296	Metabotropic glutamate receptor 5	P31424	Grm5	Rattus norvegicus (Rat)	1203
57298	Metabotropic glutamate receptor 5	P41594	GRM5	Homo sapiens (Human)	1212
57291	Metabotropic glutamate receptor 6	P35349	Grm6	Rattus norvegicus (Rat)	871
57294	Metabotropic glutamate receptor 6	O15303	GRM6	Homo sapiens (Human)	877
57282	Metabotropic glutamate receptor 7	P35400	Grm7	Rattus norvegicus (Rat)	915
57290	Metabotropic glutamate receptor 7	Q14831	GRM7	Homo sapiens (Human)	915
57283	Metabotropic glutamate receptor 8	P70579	Grm8	Rattus norvegicus (Rat)	908
57295	Metabotropic glutamate receptor 8	O00222	GRM8	Homo sapiens (Human)	908
57297	Metabotropic glutamate receptor 8	P47743	Grm8	Mus musculus (Mouse)	908

zhanglabzhanggroup.org | +65-6601-1241 | Computing 1, 13 Computing Drive, Singapore 117417