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GLASS

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GPCR

Name	Metabotropic glutamate receptor 2
Species	Homo sapiens (Human)
Gene	GRM2
Synonym	mGluR2 mGlu2 receptor metabotropic glutamate receptor 2 GPRC1B glutamate receptor
Disease	Central nervous system disease Anxiety disorder Bipolar disorder Major depressive disorder Mood disorder Psychiatric disorder Schizophrenia Alzheimer disease; Major depressive disorder [ Show all ]
Length	872
Amino acid sequence	MGSLLALLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHICPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQRLNASFTWVASDGWGALESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTLDTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADCGLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKASGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRFISPASQVAICLALISGQLLIVVAWLVVEAPGTGKETAPERREVVTLRCNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAARASSSLGQGSGSQFVPTVCNGREVVDSTTSSL
UniProt	Q14416
Protein Data Bank	5cnj, 5kzn, 5kzq, 5cni, 4xas, 4xaq
GPCR-HGmod model	N/A
3D structure model	This structure is from PDB ID 5cnj.
BioLiP	BL0365442, BL0324559,BL0324560, BL0324557,BL0324558, BL0306697,BL0306698, BL0306695,BL0306696, BL0365443
Therapeutic Target Database	T62820
ChEMBL	CHEMBL5137
IUPHAR	290
DrugBank	N/A

Ligand

Name	L-AP4
Molecular formula	C4H10NO5P
IUPAC name	(2S)-2-amino-4-phosphonobutanoic acid
Molecular weight	183.1
Hydrogen bond acceptor	6
Hydrogen bond donor	4
XlogP	-5.5
Synonyms	BDBM50007548 D08PBE HY-100781A L-150 MolPort-002-514-399 NCIStruc2_000128 ZINC2033983 2-Amino-4-phosphono-butyric acid(S-AP4) C-55169 E7P L(+)-2-Amino-4-phosphonobutanoic acid (L-AP4) NCGC00013365-03 SCHEMBL1969235 (S)-2-Amino-4-phosphono-butyric acid AC1L456H B6200 CHEMBL33567 GTPL1410 L-(+)-2-Amino-4-phosphonobutyric acid, optical purity optical purity: >=95% (HPLC, Marfey's reagent) M01257 NCI30079 Tocris-0103 BN0084 D0H7UP J-014961 L-2-amino-4-phosphonobutiric acid NCGC00013365 NSC-30079 [3H]AP4 (2S)-2-amino-4-phosphonobutanoic acid 23052-81-5 CCG-37553 FCH919870 L-(+)-2-Amino-4-phosphono-butanoic acid L-APB NCGC00024468-01 SR-01000597692 (S)-2-amino-4-phosphonobutanoic acid ACM23052815 B6202 CS-0020419 GTPL1412 L-1-amino-4-phosphonobutanoic acid MFCD00083244 NCIStruc1_000162 UNII-H8B59H10OK component DDOQBQRIEWHWBT-VKHMYHEASA-N 2-Amino-3-(3,5-dioxo-[1,2,4]oxadiazolidin-2-yl)-propionic acid Butanoic acid,2-amino-4-phosphono-,(2S)- D0PN6Z l(+)-2-amino-4-phosphonobutanoic acid L-AP-4 NCGC00013365-02 S-2-amino-4-phosphonobutyrate (2S)-2-amino-4-phosphonobutanoic acid. AKOS006239562 FT-0689296 L-(+)-2-Amino-4-phosphonobutyric acid LS-46098 NCGC00024468-02 SR-01000597692-1 [ Show all ]
Inchi Key	DDOQBQRIEWHWBT-VKHMYHEASA-N
Inchi ID	InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)/t3-/m0/s1
PubChem CID	179394
ChEMBL	CHEMBL33567
IUPHAR	1412, 1410
BindingDB	50007548
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	<1000000.0 nM	PMID7738999, PMID17350267, PMID16213710	BindingDB,ChEMBL
EC50	448000.0 nM	PMID14711315	BindingDB
EC50	1000000.0 nM	PMID9357538	BindingDB
Ki	<1000000.0 nM	PMID19042134, PMID10893301	BindingDB,ChEMBL
Ki	129000.0 nM	PMID12109902	BindingDB,ChEMBL
Ratio	295.0 -	PMID12109902	ChEMBL

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