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Name | Metabotropic glutamate receptor 8 |
---|---|
Species | Rattus norvegicus (Rat) |
Gene | Grm8 |
Synonym | GLUR8 glutamate receptor Gprc1h mGlu8 receptor mGluR8 [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 908 |
Amino acid sequence | MVCEGKRLASCPCFFLLTAKFYWILTMMQRTHSQEYAHSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKERCPGYIGLCPRMVTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQINNKSTEYKIIGHWTNQLHLKVEDMQWANREHTHPASVCSLPCKPGERKKTVKGVPCCWHCERCEGYNYQVDELSCELCPLDQRPNINRTGCQRIPIIKLEWHSPWAVVPVFIAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFLMIAAPDTIICSFRRIFLGLGMCFSYAALLTKTNRIHRIFEQGKKSVTAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPHTIIDYGEQRTLDPENARGVLKCDISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQKRKRSFKAVVTAATMQSKLIQKGNDRPNGEVKSELCESLETNTSSTKTTYISYSNHSI |
UniProt | P70579 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL2718 |
IUPHAR | 296 |
DrugBank | N/A |
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GLASS ID | Molecule | Formula | Molecular weight | H-bond acceptor / donor | XlogP | Lipinski's druglikeness |
---|---|---|---|---|---|---|
557352 | ![]() | C13H16Cl2NO8P | 416.144 | 9 / 5 | -2.6 | Yes |
535968 | ![]() | C13H16Cl2NO8P | 416.144 | 9 / 5 | -2.6 | Yes |
535988 | ![]() | C3H7NO4S | 153.152 | 5 / 2 | -4.7 | Yes |
557607 | ![]() | C14H20NO8P | 361.287 | 9 / 5 | -3.4 | Yes |
536279 | ![]() | C14H20NO8P | 361.287 | 9 / 5 | -3.4 | Yes |
12910 | ![]() | C13H11ClN2O2 | 262.693 | 3 / 1 | 2.6 | Yes |
536574 | ![]() | C13H18NO8P | 347.26 | 9 / 5 | -3.8 | Yes |
522264 | ![]() | C8H11NO6 | 217.177 | 7 / 4 | -4.0 | Yes |
522271 | ![]() | C8H11NO6 | 217.177 | 7 / 4 | -4.0 | Yes |
522276 | ![]() | C8H11NO6 | 217.177 | 7 / 4 | -4.0 | Yes |
522284 | ![]() | C8H11NO6 | 217.177 | 7 / 4 | -4.0 | Yes |
33523 | ![]() | C28H27NO5 | 457.526 | 5 / 1 | 4.8 | Yes |
536924 | ![]() | C3H8NO6P | 185.072 | 6 / 3 | -4.5 | Yes |
558419 | ![]() | C14H17F3NO8P | 415.258 | 12 / 4 | -2.1 | No |
536938 | ![]() | C14H17F3NO8P | 415.258 | 12 / 4 | -2.1 | No |
536963 | ![]() | C14H19FNO9P | 395.276 | 11 / 5 | -3.8 | No |
558444 | ![]() | C14H19FNO9P | 395.276 | 11 / 5 | -3.8 | No |
42849 | ![]() | C7H14NO6P | 239.164 | 6 / 3 | -4.2 | Yes |
42850 | ![]() | C7H14NO6P | 239.164 | 7 / 4 | -4.8 | Yes |
42854 | ![]() | C7H14NO6P | 239.164 | 7 / 4 | -4.8 | Yes |
537085 | ![]() | C14H19ClNO9P | 411.728 | 10 / 5 | -3.2 | Yes |
558599 | ![]() | C14H19ClNO9P | 411.728 | 10 / 5 | -3.2 | Yes |
519955 | ![]() | C4H10NO5P | 183.1 | 6 / 4 | -5.5 | Yes |
537400 | ![]() | C4H10NO5P | 183.1 | 6 / 4 | -5.5 | Yes |
57283 | ![]() | C4H10NO5P | 183.1 | 6 / 4 | -5.5 | Yes |
62857 | ![]() | C11H14NO5P | 271.209 | 6 / 4 | -3.3 | Yes |
62866 | ![]() | C11H14NO5P | 271.209 | 6 / 4 | -3.3 | Yes |
537500 | ![]() | C14H17F3NO7P | 399.259 | 11 / 4 | -2.4 | No |
559218 | ![]() | C14H17F3NO7P | 399.259 | 11 / 4 | -2.4 | No |
537525 | ![]() | C10H11NO4 | 209.201 | 5 / 3 | -2.0 | Yes |
537632 | ![]() | C14H20NO8P | 361.287 | 9 / 4 | -3.3 | Yes |
559390 | ![]() | C14H20NO8P | 361.287 | 9 / 4 | -3.3 | Yes |
559476 | ![]() | C15H22NO9P | 391.313 | 10 / 5 | -3.5 | Yes |
537685 | ![]() | C15H22NO9P | 391.313 | 10 / 5 | -3.5 | Yes |
82271 | ![]() | C15H13FN2O2 | 272.279 | 4 / 1 | 2.1 | Yes |
85068 | ![]() | C7H13ClNO6P | 273.606 | 7 / 4 | -4.1 | Yes |
100373 | ![]() | C8H14NO6P | 251.175 | 7 / 3 | -4.7 | Yes |
553767 | ![]() | C4H10NO6P | 199.099 | 7 / 4 | -5.0 | Yes |
109296 | ![]() | C6H9NO4 | 159.141 | 5 / 3 | -3.4 | Yes |
110382 | ![]() | C5H9NO5 | 163.129 | 5 / 3 | -3.4 | Yes |
110385 | ![]() | C5H9NO5 | 163.129 | 6 / 4 | -4.1 | Yes |
538734 | ![]() | C15H22NO8P | 375.314 | 9 / 5 | -3.1 | Yes |
560798 | ![]() | C15H22NO8P | 375.314 | 9 / 5 | -3.1 | Yes |
560845 | ![]() | C25H16FN5O2 | 437.434 | 6 / 2 | 3.6 | Yes |
538882 | ![]() | C14H18NO10P | 391.269 | 11 / 6 | -4.3 | No |
560945 | ![]() | C14H18NO10P | 391.269 | 11 / 6 | -4.3 | No |
538899 | ![]() | C14H19FNO8P | 379.277 | 10 / 4 | -3.2 | Yes |
560963 | ![]() | C14H19FNO8P | 379.277 | 10 / 4 | -3.2 | Yes |
553881 | ![]() | C5H12NO5P | 197.127 | 6 / 4 | -4.6 | Yes |
128446 | ![]() | C5H12NO4P | 181.128 | 5 / 3 | -5.0 | Yes |
130322 | ![]() | C4H10NO4P | 167.101 | 5 / 3 | -5.1 | Yes |
553950 | ![]() | C11H14NO5P | 271.209 | 6 / 4 | -3.1 | Yes |
135011 | ![]() | C10H9NO6 | 239.183 | 7 / 4 | -2.7 | Yes |
561523 | ![]() | C13H16F2NO8P | 383.241 | 11 / 5 | -3.6 | No |
539423 | ![]() | C13H16F2NO8P | 383.241 | 11 / 5 | -3.6 | No |
539453 | ![]() | C13H18NO7PS | 363.321 | 9 / 5 | -3.3 | Yes |
561553 | ![]() | C13H18NO7PS | 363.321 | 9 / 5 | -3.3 | Yes |
138528 | ![]() | C9H18NO7P | 283.217 | 8 / 5 | -5.1 | Yes |
539800 | ![]() | C15H22NO10P | 407.312 | 11 / 5 | -3.9 | No |
561930 | ![]() | C15H22NO10P | 407.312 | 11 / 5 | -3.9 | No |
158295 | ![]() | C8H10NO5P | 231.144 | 6 / 4 | -3.7 | Yes |
181956 | ![]() | C5H10NO5P | 195.111 | 6 / 4 | -4.7 | Yes |
181966 | ![]() | C5H10NO5P | 195.111 | 6 / 4 | -4.7 | Yes |
181969 | ![]() | C5H10NO5P | 195.111 | 6 / 4 | -4.7 | Yes |
187014 | ![]() | C6H9NO5 | 175.14 | 6 / 4 | -3.9 | Yes |
187025 | ![]() | C6H9NO5 | 175.14 | 6 / 4 | -3.9 | Yes |
540899 | ![]() | C15H20NO11P | 421.295 | 12 / 6 | -4.3 | No |
563228 | ![]() | C15H20NO11P | 421.295 | 12 / 6 | -4.3 | No |
189227 | ![]() | C21H16ClN3O3 | 393.827 | 4 / 1 | 2.6 | Yes |
541003 | ![]() | C14H20NO9P | 377.286 | 10 / 5 | -3.9 | Yes |
563328 | ![]() | C14H20NO9P | 377.286 | 10 / 5 | -3.9 | Yes |
201020 | ![]() | C7H9NO6 | 203.15 | 7 / 4 | -4.3 | Yes |
213638 | ![]() | C19H13Cl2N3O2 | 386.232 | 3 / 2 | 4.1 | Yes |
222189 | ![]() | C9H17ClNO7P | 317.659 | 8 / 6 | N/A | No |
550722 | ![]() | C12H19NO9P2 | 383.23 | 10 / 6 | -5.2 | No |
564460 | ![]() | C12H19NO9P2 | 383.23 | 10 / 6 | -5.2 | No |
542101 | ![]() | C14H17F3NO9P | 431.257 | 13 / 5 | -2.7 | No |
564553 | ![]() | C14H17F3NO9P | 431.257 | 13 / 5 | -2.7 | No |
542300 | ![]() | C14H19N2O11P | 422.283 | 12 / 5 | -4.0 | No |
564755 | ![]() | C14H19N2O11P | 422.283 | 12 / 5 | -4.0 | No |
542744 | ![]() | C9H12NO5P | 245.171 | 6 / 4 | -3.5 | Yes |
542781 | ![]() | C4H9NO4S | 167.179 | 6 / 3 | -3.8 | Yes |
259128 | ![]() | C9H16NO8P | 297.2 | 9 / 5 | -5.3 | Yes |
543034 | ![]() | C14H19ClNO8P | 395.729 | 9 / 4 | -2.7 | Yes |
565523 | ![]() | C14H19ClNO8P | 395.729 | 9 / 4 | -2.7 | Yes |
265337 | ![]() | C26H22ClNO3 | 431.916 | 3 / 1 | 5.6 | No |
543558 | ![]() | C14H18NO7P | 343.272 | 8 / 5 | -3.5 | Yes |
565981 | ![]() | C14H18NO7P | 343.272 | 8 / 5 | -3.5 | Yes |
282813 | ![]() | C6H12NO6P | 225.137 | 7 / 4 | -4.7 | Yes |
566050 | ![]() | C7H12NO6P | 237.148 | 7 / 4 | -2.1 | Yes |
292330 | ![]() | C24H18ClNO4S | 451.921 | 5 / 1 | 5.3 | No |
310567 | ![]() | C4H10NO4PS | 199.161 | 6 / 4 | -3.8 | Yes |
544479 | ![]() | C11H15NO2 | 193.246 | 3 / 1 | 2.2 | Yes |
316449 | ![]() | C9H16NO6P | 265.202 | 7 / 3 | -4.4 | Yes |
319662 | ![]() | C6H12NO7P | 241.136 | 8 / 5 | -5.3 | Yes |
323922 | ![]() | C12H9ClN2O | 232.667 | 2 / 1 | 2.6 | Yes |
544826 | ![]() | C13H20NO7P | 333.277 | 8 / 5 | -4.1 | Yes |
567540 | ![]() | C13H20NO7P | 333.277 | 8 / 5 | -4.1 | Yes |
567705 | ![]() | C14H17F3NO8P | 415.258 | 12 / 5 | -3.0 | No |
544957 | ![]() | C14H17F3NO8P | 415.258 | 12 / 5 | -3.0 | No |
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