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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Metabotropic glutamate receptor 8
Species	Rattus norvegicus (Rat)
Gene	Grm8
Synonym	GLUR8 glutamate receptor Gprc1h mGlu8 receptor mGluR8 mGluR8b [ Show all ]
Disease	N/A for non-human GPCRs
Length	908
Amino acid sequence	MVCEGKRLASCPCFFLLTAKFYWILTMMQRTHSQEYAHSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKERCPGYIGLCPRMVTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQINNKSTEYKIIGHWTNQLHLKVEDMQWANREHTHPASVCSLPCKPGERKKTVKGVPCCWHCERCEGYNYQVDELSCELCPLDQRPNINRTGCQRIPIIKLEWHSPWAVVPVFIAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFLMIAAPDTIICSFRRIFLGLGMCFSYAALLTKTNRIHRIFEQGKKSVTAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPHTIIDYGEQRTLDPENARGVLKCDISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQKRKRSFKAVVTAATMQSKLIQKGNDRPNGEVKSELCESLETNTSSTKTTYISYSNHSI
UniProt	P70579
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2718
IUPHAR	296
DrugBank	N/A

Ligand

Name	MPPG
Molecular formula	C9H12NO5P
IUPAC name	2-amino-2-(4-phosphonophenyl)propanoic acid
Molecular weight	245.171
Hydrogen bond acceptor	6
Hydrogen bond donor	4
XlogP	-3.5
Synonyms	CTK8F0596 API0007557 GTPL1415 RT-013949 2-Amino-2-(4-phosphono-phenyl)-propionic acid(RS-MPPG) MFCD00672651 SR-01000597457-1 (RS)-?-Methyl-4-phosphonophenylglycine AC1N11KO D0D2GL MPPG, >=97% (NMR), solid 169209-65-8 BDBM50089910 J-010517 SCHEMBL12648709 2-amino-2-(4-phosphonophenyl)propanoic acid CHEMBL86508 MolPort-003-983-629 (RS)-\|A-Methyl-4-phosphonophenylglycine AKOS024458668 DTXSID80398316 NCGC00024826-02 2-Amino-2-(4-phosphono-phenyl)-propionic acid BN0344 L000410 SR-01000597457 [ Show all ]
Inchi Key	PAONCRJPUQXPRW-UHFFFAOYSA-N
Inchi ID	InChI=1S/C9H12NO5P/c1-9(10,8(11)12)6-2-4-7(5-3-6)16(13,14)15/h2-5H,10H2,1H3,(H,11,12)(H2,13,14,15)
PubChem CID	3972752
ChEMBL	CHEMBL86508
IUPHAR	1415
BindingDB	50089910
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	480.0 nM	PMID11114395	BindingDB

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