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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Metabotropic glutamate receptor 8
Species	Rattus norvegicus (Rat)
Gene	Grm8
Synonym	GLUR8 glutamate receptor Gprc1h mGlu8 receptor mGluR8 mGluR8b [ Show all ]
Disease	N/A for non-human GPCRs
Length	908
Amino acid sequence	MVCEGKRLASCPCFFLLTAKFYWILTMMQRTHSQEYAHSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKERCPGYIGLCPRMVTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQINNKSTEYKIIGHWTNQLHLKVEDMQWANREHTHPASVCSLPCKPGERKKTVKGVPCCWHCERCEGYNYQVDELSCELCPLDQRPNINRTGCQRIPIIKLEWHSPWAVVPVFIAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFLMIAAPDTIICSFRRIFLGLGMCFSYAALLTKTNRIHRIFEQGKKSVTAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPHTIIDYGEQRTLDPENARGVLKCDISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQKRKRSFKAVVTAATMQSKLIQKGNDRPNGEVKSELCESLETNTSSTKTTYISYSNHSI
UniProt	P70579
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2718
IUPHAR	296
DrugBank	N/A

Ligand

Name	2485-33-8
Molecular formula	C5H9NO5
IUPAC name	(2S,4R)-2-amino-4-hydroxypentanedioic acid
Molecular weight	163.129
Hydrogen bond acceptor	6
Hydrogen bond donor	4
XlogP	-4.1
Synonyms	(4R)-4-Hydroxy-L-glutamic acid, >=98.0% (TLC) CHEBI:21285 H-(2S,4R)--Hydroxy-Glu-OH SCHEMBL5819946 (2S,4R)-4-Hydroxyglutamic Acid CTK8F1736 H-(2S,4R)-\|A-Hydroxy-Glu-OH (2S,4R)-gamma-Hydroxyglutamic acid AKOS006271402 erythro-4-hydroxy-L-glutamic acid L-erythro-4-hydroxyglutamic acid (2S,4R)-2-amino-4-hydroxypentanedioic acid (4S)-4-hydroxy-L-glutamic acid H-(2S,4R)-Gamma-Hydroxy-Glu-OH ZINC895967 (2S,4R)-g-4-Hydroxy-L-glutamic Acid 7033AH DTXSID90331532 J-015700 (4R)-4-Hydroxy-L-glutamic acid C05947 FT-0669646 L-Glutamic acid,4-hydroxy-,(4R)- (2S,4R)-4-Hydroxy-L-glutamic Acid CHEMBL371946 H-(2S,4R)-Glu(g-OH)-OH (2S,4R)-gamma-Hydroxy-glutamic acid AC1L9A2D erythro-(4R)-4-Hydroxy-L-glutamic acid L-erythro-4-Hydroxyglutamate [ Show all ]
Inchi Key	HBDWQSHEVMSFGY-STHAYSLISA-N
Inchi ID	InChI=1S/C5H9NO5/c6-2(4(8)9)1-3(7)5(10)11/h2-3,7H,1,6H2,(H,8,9)(H,10,11)/t2-,3+/m0/s1
PubChem CID	440854
ChEMBL	CHEMBL371946
IUPHAR	N/A
BindingDB	50100941
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	69000.0 nM	PMID11412983	BindingDB,ChEMBL
Rmax	54.0 mM	PMID11412983	ChEMBL

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