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GLASS

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GPCR

Name	Metabotropic glutamate receptor 8
Species	Rattus norvegicus (Rat)
Gene	Grm8
Synonym	GLUR8 glutamate receptor Gprc1h mGlu8 receptor mGluR8 mGluR8b [ Show all ]
Disease	N/A for non-human GPCRs
Length	908
Amino acid sequence	MVCEGKRLASCPCFFLLTAKFYWILTMMQRTHSQEYAHSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKERCPGYIGLCPRMVTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQINNKSTEYKIIGHWTNQLHLKVEDMQWANREHTHPASVCSLPCKPGERKKTVKGVPCCWHCERCEGYNYQVDELSCELCPLDQRPNINRTGCQRIPIIKLEWHSPWAVVPVFIAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFLMIAAPDTIICSFRRIFLGLGMCFSYAALLTKTNRIHRIFEQGKKSVTAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPHTIIDYGEQRTLDPENARGVLKCDISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQKRKRSFKAVVTAATMQSKLIQKGNDRPNGEVKSELCESLETNTSSTKTTYISYSNHSI
UniProt	P70579
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2718
IUPHAR	296
DrugBank	N/A

Ligand

Name	(2S,1'S,2'S)-2-(carboxycyclopropyl)glycine
Molecular formula	C6H9NO4
IUPAC name	(1S,2S)-2-[(S)-amino(carboxy)methyl]cyclopropane-1-carboxylic acid
Molecular weight	159.141
Hydrogen bond acceptor	5
Hydrogen bond donor	3
XlogP	-3.4
Synonyms	L-Ccg-I NCGC00024541-04 117857-93-9 AKOS006275493 Cyclopropaneacetic acid, alpha-amino-2-carboxy-, (alphaS,1S,2S)- Lopac0_000374 SCHEMBL664330 (1S,2S)-2-((S)-Amino-carboxy-methyl)-cyclopropanecarboxylic acid 2-(Amino-carboxy-methyl)-cyclopropanecarboxylic acid(2S,3S,4S-CCG) C-237 GTPL1368 L-2-(Carboxypropyl)glycine NCGC00024541-02 Tox21_500374 L-CCG-l NCGC00024541-05 B6264 D0Z7CZ HMS3261K09 LP00374 SR-01000075799 (1S,2S)-2-[(1S)-1-amino-2-hydroxy-2-oxoethyl]cyclopropane-1-carboxylic acid 2S,1'S,2'S)-2-(Carboxycyclopropyl)Glycine CCG-204469 L-CCG-1 NCGC00024541-03 ZINC2568218 (2S,3S,4S)-CCG AC1NSJQB CHEMBL280563 L-CCGI NCGC00261059-01 (1S,2S)-2-((S)-Amino(carboxy)methyl)cyclopropanecarboxylic acid 2-(Amino-carboxy-methyl)-cyclopropanecarboxylic acid BDBM50034504 EU-0100374 J-003677 MolPort-003-940-678 SR-01000075799-1 (2S,1 inverted exclamation markaS,2 inverted exclamation markaS)-2-(Carboxycyclopropyl)glycine 3,4-Cyclopropylglutamate CCPG [ Show all ]
Inchi Key	GZOVEPYOCJWRFC-HZLVTQRSSA-N
Inchi ID	InChI=1S/C6H9NO4/c7-4(6(10)11)2-1-3(2)5(8)9/h2-4H,1,7H2,(H,8,9)(H,10,11)/t2-,3-,4-/m0/s1
PubChem CID	5310956
ChEMBL	CHEMBL280563
IUPHAR	1368
BindingDB	50034504
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	400.0 nM	PMID14711315	BindingDB,ChEMBL
EC50	630.957 nM	PMID9016353	IUPHAR

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