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GLASS

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GPCR

Name	Metabotropic glutamate receptor 8
Species	Rattus norvegicus (Rat)
Gene	Grm8
Synonym	GLUR8 glutamate receptor Gprc1h mGlu8 receptor mGluR8 mGluR8b [ Show all ]
Disease	N/A for non-human GPCRs
Length	908
Amino acid sequence	MVCEGKRLASCPCFFLLTAKFYWILTMMQRTHSQEYAHSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKERCPGYIGLCPRMVTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQINNKSTEYKIIGHWTNQLHLKVEDMQWANREHTHPASVCSLPCKPGERKKTVKGVPCCWHCERCEGYNYQVDELSCELCPLDQRPNINRTGCQRIPIIKLEWHSPWAVVPVFIAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFLMIAAPDTIICSFRRIFLGLGMCFSYAALLTKTNRIHRIFEQGKKSVTAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPHTIIDYGEQRTLDPENARGVLKCDISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQKRKRSFKAVVTAATMQSKLIQKGNDRPNGEVKSELCESLETNTSSTKTTYISYSNHSI
UniProt	P70579
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2718
IUPHAR	296
DrugBank	N/A

Ligand

Name	demethylphosphinothricin
Molecular formula	C4H10NO4P
IUPAC name	(2S)-2-amino-4-hydroxyphosphonoylbutanoic acid
Molecular weight	167.101
Hydrogen bond acceptor	5
Hydrogen bond donor	3
XlogP	-5.1
Synonyms	(2S)-2-Amino-4-(hydroxyphosphinyl)butanoic acid AC1L4KJ0 (2S)-2-amino-4-hydroxyphosphonoylbutanoic acid C17962
Inchi Key	IDBRULKICVRMNG-VKHMYHEASA-N
Inchi ID	InChI=1S/C4H10NO4P/c5-3(4(6)7)1-2-10(8)9/h3,10H,1-2,5H2,(H,6,7)(H,8,9)/t3-/m0/s1
PubChem CID	158745
ChEMBL	CHEMBL241972
IUPHAR	N/A
BindingDB	50220009
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	1720.0 nM	PMID17722902	BindingDB,ChEMBL

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