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GLASS

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GPCR

Name	Metabotropic glutamate receptor 1
Species	Homo sapiens (Human)
Gene	GRM1
Synonym	SCAR13 MGLUR1 mGlu1 receptor metabotropic glutamate receptor 1 GPRC1A glutamate receptor, metabotropic 1 glutamate receptor wobl [ Show all ]
Disease	Alzheimer disease; Huntington's disease Neurological disease Neuropathic pain Schizophrenia Pain
Length	1194
Amino acid sequence	MVGLLLFFFPAIFLEVSLLPRSPGRKVLLAGASSQRSVARMDGDVIIGALFSVHHQPPAEKVPERKCGEIREQYGIQRVEAMFHTLDKINADPVLLPNITLGSEIRDSCWHSSVALEQSIEFIRDSLISIRDEKDGINRCLPDGQSLPPGRTKKPIAGVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQARAMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSDKIYSNAGEKSFDRLLRKLRERLPKARVVVCFCEGMTVRGLLSAMRRLGVVGEFSLIGSDGWADRDEVIEGYEVEANGGITIKLQSPEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQCRLPGHLLENPNFKRICTGNESLEENYVQDSKMGFVINAIYAMAHGLQNMHHALCPGHVGLCDAMKPIDGSKLLDFLIKSSFIGVSGEEVWFDEKGDAPGRYDIMNLQYTEANRYDYVHVGTWHEGVLNIDDYKIQMNKSGVVRSVCSEPCLKGQIKVIRKGEVSCCWICTACKENEYVQDEFTCKACDLGWWPNADLTGCEPIPVRYLEWSNIESIIAIAFSCLGILVTLFVTLIFVLYRDTPVVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMCYSALVTKTNRIARILAGSKKKICTRKPRFMSAWAQVIIASILISVQLTLVVTLIIMEPPMPILSYPSIKEVYLICNTSNLGVVAPLGYNGLLIMSCTYYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITTCFAVSLSVTVALGCMFTPKMYIIIAKPERNVRSAFTTSDVVRMHVGDGKLPCRSNTFLNIFRRKKAGAGNANSNGKSVSWSEPGGGQVPKGQHMWHRLSVHVKTNETACNQTAVIKPLTKSYQGSGKSLTFSDTSTKTLYNVEEEEDAQPIRFSPPGSPSMVVHRRVPSAATTPPLPSHLTAEETPLFLAEPALPKGLPPPLQQQQQPPPQQKSLMDQLQGVVSNFSTAIPDFHAVLAGPGGPGNGLRSLYPPPPPPQHLQMLPLQLSTFGEELVSPPADDDDDSERFKLLQEYVYEHEREGNTEEDELEEEEEDLQAASKLTPDDSPALTPPSPFRDSVASGSSVPSSPVSESVLCTPPNVSYASVILRDYKQSSSTL
UniProt	Q13255
Protein Data Bank	4or2, 3ks9
GPCR-HGmod model	N/A
3D structure model	This structure is from PDB ID 4or2.
BioLiP	BL0271871,BL0271876, BL0271872,BL0271873,BL0271874,, BL0174211,BL0174213, BL0174210,BL0174212
Therapeutic Target Database	T27137
ChEMBL	CHEMBL3772
IUPHAR	289
DrugBank	BE0000824

Ligand

Name	L-AP4
Molecular formula	C4H10NO5P
IUPAC name	(2S)-2-amino-4-phosphonobutanoic acid
Molecular weight	183.1
Hydrogen bond acceptor	6
Hydrogen bond donor	4
XlogP	-5.5
Synonyms	AKOS006239562 FT-0689296 L-(+)-2-Amino-4-phosphonobutyric acid LS-46098 NCGC00024468-02 SR-01000597692-1 2-Amino-4-phosphono-butyric acid(S-AP4) BDBM50007548 D08PBE HY-100781A L-150 MolPort-002-514-399 NCIStruc2_000128 ZINC2033983 (S)-2-Amino-4-phosphono-butyric acid AC1L456H C-55169 E7P L(+)-2-Amino-4-phosphonobutanoic acid (L-AP4) NCGC00013365-03 SCHEMBL1969235 B6200 CHEMBL33567 GTPL1410 L-(+)-2-Amino-4-phosphonobutyric acid, optical purity optical purity: >=95% (HPLC, Marfey's reagent) M01257 NCI30079 Tocris-0103 (2S)-2-amino-4-phosphonobutanoic acid 23052-81-5 BN0084 D0H7UP J-014961 L-2-amino-4-phosphonobutiric acid NCGC00013365 NSC-30079 [3H]AP4 (S)-2-amino-4-phosphonobutanoic acid ACM23052815 CCG-37553 FCH919870 L-(+)-2-Amino-4-phosphono-butanoic acid L-APB NCGC00024468-01 SR-01000597692 2-Amino-3-(3,5-dioxo-[1,2,4]oxadiazolidin-2-yl)-propionic acid B6202 CS-0020419 GTPL1412 L-1-amino-4-phosphonobutanoic acid MFCD00083244 NCIStruc1_000162 UNII-H8B59H10OK component DDOQBQRIEWHWBT-VKHMYHEASA-N (2S)-2-amino-4-phosphonobutanoic acid. Butanoic acid,2-amino-4-phosphono-,(2S)- D0PN6Z l(+)-2-amino-4-phosphonobutanoic acid L-AP-4 NCGC00013365-02 S-2-amino-4-phosphonobutyrate [ Show all ]
Inchi Key	DDOQBQRIEWHWBT-VKHMYHEASA-N
Inchi ID	InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)/t3-/m0/s1
PubChem CID	179394
ChEMBL	CHEMBL33567
IUPHAR	1410, 1412
BindingDB	50007548
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<1000000.0 nM	PMID19042134, PMID10893301	BindingDB,ChEMBL

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