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| Name | Metabotropic glutamate receptor 6 |
|---|---|
| Species | Homo sapiens (Human) |
| Gene | GRM6 |
| Synonym | nob3 nob2 nerg1 mGluR6 mGlu6 receptor [ Show all ] |
| Disease | N/A |
| Length | 877 |
| Amino acid sequence | MARPRRAREPLLVALLPLAWLAQAGLARAAGSVRLAGGLTLGGLFPVHARGAAGRACGQLKKEQGVHRLEAMLYALDRVNADPELLPGVRLGARLLDTCSRDTYALEQALSFVQALIRGRGDGDEVGVRCPGGVPPLRPAPPERVVAVVGASASSVSIMVANVLRLFAIPQISYASTAPELSDSTRYDFFSRVVPPDSYQAQAMVDIVRALGWNYVSTLASEGNYGESGVEAFVQISREAGGVCIAQSIKIPREPKPGEFSKVIRRLMETPNARGIIIFANEDDIRRVLEAARQANLTGHFLWVGSDSWGAKTSPILSLEDVAVGAITILPKRASIDGFDQYFMTRSLENNRRNIWFAEFWEENFNCKLTSSGTQSDDSTRKCTGEERIGRDSTYEQEGKVQFVIDAVYAIAHALHSMHQALCPGHTGLCPAMEPTDGRMLLQYIRAVRFNGSAGTPVMFNENGDAPGRYDIFQYQATNGSASSGGYQAVGQWAETLRLDVEALQWSGDPHEVPSSLCSLPCGPGERKKMVKGVPCCWHCEACDGYRFQVDEFTCEACPGDMRPTPNHTGCRPTPVVRLSWSSPWAAPPLLLAVLGIVATTTVVATFVRYNNTPIVRASGRELSYVLLTGIFLIYAITFLMVAEPGAAVCAARRLFLGLGTTLSYSALLTKTNRIYRIFEQGKRSVTPPPFISPTSQLVITFSLTSLQVVGMIAWLGARPPHSVIDYEEQRTVDPEQARGVLKCDMSDLSLIGCLGYSLLLMVTCTVYAIKARGVPETFNEAKPIGFTMYTTCIIWLAFVPIFFGTAQSAEKIYIQTTTLTVSLSLSASVSLGMLYVPKTYVILFHPEQNVQKRKRSLKATSTVAAPPKGEDAEAHK |
| UniProt | O15303 |
| Protein Data Bank | N/A |
| GPCR-HGmod model | N/A |
| 3D structure model | No available structures or models |
| BioLiP | N/A |
| Therapeutic Target Database | N/A |
| ChEMBL | CHEMBL4573 |
| IUPHAR | 294 |
| DrugBank | N/A |
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| GLASS ID | Molecule | Formula | Molecular weight | H-bond acceptor / donor | XlogP | Lipinski's druglikeness |
|---|---|---|---|---|---|---|
| 4947 |  CHEMBL1099113 | C23H16N2 | 320.395 | 2 / 0 | 5.6 | No |
| 8268 |  CHEMBL2208408 | C15H15ClN2O3S | 338.806 | 4 / 1 | 2.6 | Yes |
| 8569 |  42160-26-9 | C12H10N2S | 214.286 | 3 / 1 | 3.6 | Yes |
| 9972 |  CHEMBL575695 | C21H19NO3S | 365.447 | 4 / 1 | 5.6 | No |
| 11482 |  CHEMBL2381648 | C10H14N2O5 | 242.231 | 6 / 4 | -4.2 | Yes |
| 11486 |  CHEMBL2381649 | C10H14N2O5 | 242.231 | 6 / 4 | -4.2 | Yes |
| 13319 |  QUISQUALIC ACID | C5H7N3O5 | 189.127 | 6 / 3 | -3.9 | Yes |
| 13329 |  2-amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl)propanoic acid | C5H7N3O5 | 189.127 | 6 / 3 | -3.9 | Yes |
| 13422 |  CHEMBL568515 | C15H17NO2S | 275.366 | 4 / 1 | 4.6 | Yes |
| 17047 |  CHEMBL493571 | C14H11N3O | 237.262 | 3 / 1 | 2.1 | Yes |
| 465377 |  AC1N2AWG | C24H24N2O4S | 436.526 | 5 / 1 | 4.1 | Yes |
| 553359 |  LSP4-2022 | C13H18NO8P | 347.26 | 9 / 5 | -3.8 | Yes |
| 24451 |  CHEMBL2381647 | C8H12N2O4 | 200.194 | 6 / 4 | -6.7 | Yes |
| 24456 |  CHEMBL2381646 | C8H12N2O4 | 200.194 | 6 / 4 | -6.7 | Yes |
| 25092 |  CHEMBL523693 | C20H12N2 | 280.33 | 2 / 0 | 4.3 | Yes |
| 28072 |  CHEMBL567872 | C17H20N2O2S2 | 348.479 | 4 / 2 | 4.7 | Yes |
| 30706 |  CHEMBL365368 | C9H13NO4 | 199.206 | 5 / 3 | -2.8 | Yes |
| 30714 |  LY 395756 | C9H13NO4 | 199.206 | 5 / 3 | -2.8 | Yes |
| 32525 |  CHEMBL469121 | C18H14FN3O | 307.328 | 4 / 1 | 3.1 | Yes |
| 35630 |  miconazole | C18H14Cl4N2O | 416.123 | 2 / 0 | 5.3 | No |
| 35745 |  CHEMBL1099112 | C17H11ClN2 | 278.739 | 2 / 0 | 4.6 | Yes |
| 35788 |  BDBM50388941 | C16H13N3O3 | 295.298 | 5 / 1 | 1.4 | Yes |
| 36684 |  CID 57689797 | C3H8NO6P | 185.072 | 6 / 3 | -4.5 | Yes |
| 36691 |  dl-O-Phosphoserine | C3H8NO6P | 185.072 | 7 / 4 | -5.1 | Yes |
| 36864 |  CHEMBL239906 | C8H11NO6 | 217.177 | 7 / 4 | -3.4 | Yes |
| 467498 |  CHEMBL3605296 | C20H17N5O3 | 375.388 | 6 / 1 | 2.1 | Yes |
| 39695 |  4506-71-2 | C11H15NO2S | 225.306 | 4 / 1 | 3.3 | Yes |
| 42349 |  CHEMBL573222 | C12H11NO2S | 233.285 | 4 / 2 | 3.4 | Yes |
| 43214 |  CHEMBL467485 | C20H17FN2O | 320.367 | 3 / 1 | 4.5 | Yes |
| 44168 |  [3H]-L-aspartate | C4H7NO4 | 133.103 | 4 / 2 | -2.1 | Yes |
| 44173 |  D-Aspartic acid | C4H7NO4 | 133.103 | 5 / 3 | -2.8 | Yes |
| 51352 |  CHEMBL397121 | C18H13F2N3O | 325.319 | 5 / 1 | 3.5 | Yes |
| 469260 |  CHEMBL3628115 | C19H12ClN3O4 | 381.772 | 5 / 1 | 2.6 | Yes |
| 469954 |  CHEMBL3628112 | C20H12Cl2N2O4 | 415.226 | 4 / 1 | 4.3 | Yes |
| 57280 |  2-amino-4-phosphonobutanoic acid | C4H10NO5P | 183.1 | 6 / 4 | -5.5 | Yes |
| 57294 |  L-AP4 | C4H10NO5P | 183.1 | 6 / 4 | -5.5 | Yes |
| 59285 |  CHEMBL313394 | C9H13NO4 | 199.206 | 5 / 3 | -2.9 | Yes |
| 61029 |  CHEMBL1099115 | C22H15N3 | 321.383 | 3 / 0 | 4.5 | Yes |
| 61164 |  CHEMBL334014 | C8H10FNO4 | 203.169 | 6 / 3 | -3.2 | Yes |
| 64471 |  CHEMBL523856 | C17H14N4O | 290.326 | 4 / 1 | 1.9 | Yes |
| 65637 |  CHEMBL565260 | C18H17NO2S | 311.399 | 3 / 0 | 4.6 | Yes |
| 65727 |  MLS000035540 | C12H14N2OS2 | 266.377 | 4 / 1 | 3.2 | Yes |
| 68126 |  CHEMBL81147 | C10H14NO5P | 259.198 | 6 / 4 | -3.2 | Yes |
| 69222 |  CHEMBL566318 | C18H15NOS | 293.384 | 3 / 1 | 5.2 | No |
| 74020 |  CHEMBL464550 | C13H10F2N2O | 248.233 | 4 / 1 | 2.6 | Yes |
| 74839 |  CHEMBL578045 | C15H15NO4S | 305.348 | 5 / 2 | 4.0 | Yes |
| 75321 |  CHEMBL1096196 | C16H10ClN3 | 279.727 | 3 / 0 | 3.8 | Yes |
| 76802 |  4815-28-5 | C9H12N2OS | 196.268 | 3 / 2 | 1.9 | Yes |
| 80681 |  CHEMBL181483 | C15H10N2 | 218.259 | 2 / 0 | 3.0 | Yes |
| 85075 |  (2S,3S)-3-(carboxymethyl)azetidine-2-carboxylic acid | C6H9NO4 | 159.141 | 5 / 3 | -3.3 | Yes |
| 89830 |  Ethyl 2-amino-4-methyl-5-phenylthiophene-3-carboxylate | C14H15NO2S | 261.339 | 4 / 1 | 4.1 | Yes |
| 524130 |  CHEMBL3804910 | C23H35N5O3 | 429.565 | 5 / 0 | 3.7 | Yes |
| 90918 |  CHEMBL575059 | C14H13ClO2S | 280.766 | 3 / 0 | 4.8 | Yes |
| 94010 |  CHEMBL567871 | C21H28N2O3S | 388.526 | 5 / 2 | 5.3 | No |
| 95881 |  CHEMBL1098805 | C22H16N2OS | 356.443 | 4 / 0 | 5.6 | No |
| 99231 |  CHEMBL333519 | C8H10FNO4 | 203.169 | 6 / 3 | -3.0 | Yes |
| 101843 |  CHEMBL584345 | C15H13N3O2S | 299.348 | 6 / 0 | 4.5 | Yes |
| 553777 |  D0N9UZ | C12H13N5O6 | 323.265 | 8 / 5 | -4.7 | Yes |
| 107854 |  CHEMBL1098212 | C16H9F3N2O3S2 | 398.374 | 9 / 0 | 4.9 | Yes |
| 109294 |  (2S,1'S,2'S)-2-(carboxycyclopropyl)glycine | C6H9NO4 | 159.141 | 5 / 3 | -3.4 | Yes |
| 110280 |  CHEMBL467484 | C20H17FN2O2 | 336.366 | 4 / 1 | 4.1 | Yes |
| 477086 |  CHEMBL3628113 | C20H12ClFN2O4 | 398.774 | 5 / 1 | 3.8 | Yes |
| 524874 |  CHEMBL3804846 | C22H14F2N2O2 | 376.363 | 5 / 1 | 3.9 | Yes |
| 119479 |  3-chloro-N-(6-methylpyridin-2-yl)benzamide | C13H11ClN2O | 246.694 | 2 / 1 | 3.0 | Yes |
| 120199 |  CHEMBL1096811 | C19H16N2O2 | 304.349 | 4 / 0 | 3.9 | Yes |
| 122092 |  3-cyano-N-(6-methylpyridin-2-yl)benzamide | C14H11N3O | 237.262 | 3 / 1 | 2.1 | Yes |
| 525131 |  CHEMBL3806176 | C21H26N4O | 350.466 | 3 / 0 | 4.3 | Yes |
| 125504 |  CHEMBL493773 | C20H11FN2 | 298.32 | 3 / 0 | 4.4 | Yes |
| 128837 |  CHEMBL9790 | C9H2N4O4 | 230.139 | 5 / 0 | 0.7 | Yes |
| 553954 |  (S)-3,4-DCPG | C10H9NO6 | 239.183 | 7 / 4 | -2.7 | Yes |
| 137463 |  CHEMBL1098228 | C24H18N2O | 350.421 | 3 / 0 | 5.4 | No |
| 140044 |  Ibotenic acid | C5H6N2O4 | 158.113 | 5 / 3 | -3.9 | Yes |
| 142495 |  CHEMBL468525 | C19H15ClN2O | 322.792 | 2 / 1 | 4.7 | Yes |
| 142733 |  CHEMBL567859 | C18H19NO5S | 361.412 | 6 / 1 | 4.6 | Yes |
| 147368 |  CHEMBL43857 | C8H11NO4 | 185.179 | 5 / 3 | -3.2 | Yes |
| 147373 |  CHEMBL46527 | C8H11NO4 | 185.179 | 5 / 3 | -3.2 | Yes |
| 147381 |  CHEMBL90501 | C8H11NO4 | 185.179 | 5 / 3 | -3.2 | Yes |
| 147386 |  CHEMBL296054 | C8H11NO4 | 185.179 | 5 / 3 | -3.2 | Yes |
| 147392 |  CHEMBL42148 | C8H11NO4 | 185.179 | 5 / 3 | -3.2 | Yes |
| 150451 |  CHEMBL583103 | C12H17N3O2S | 267.347 | 3 / 3 | 2.0 | Yes |
| 151082 |  CHEMBL493573 | C19H17N3O2 | 319.364 | 4 / 1 | 2.9 | Yes |
| 158302 |  (RS)-PPG | C8H10NO5P | 231.144 | 6 / 4 | -3.7 | Yes |
| 160375 |  2-Aminoheptanedioic acid | C7H13NO4 | 175.184 | 5 / 3 | -2.6 | Yes |
| 162005 |  CHEMBL365403 | C18H13NS | 275.369 | 2 / 0 | 5.0 | Yes |
| 163552 |  CHEMBL577710 | C17H20N2O3S | 332.418 | 4 / 2 | 4.1 | Yes |
| 164082 |  CHEMBL1096844 | C20H12N2S | 312.39 | 3 / 0 | 5.3 | No |
| 167547 |  MGS-0028 | C8H8FNO5 | 217.152 | 7 / 3 | -4.2 | Yes |
| 171342 |  4-bromo-N-(6-methylpyridin-2-yl)benzamide | C13H11BrN2O | 291.148 | 2 / 1 | 3.1 | Yes |
| 174589 |  CHEMBL324686 | C9H14N2O4 | 214.221 | 5 / 3 | -2.5 | Yes |
| 175053 |  CHEMBL493572 | C17H14N4O | 290.326 | 4 / 1 | 1.9 | Yes |
| 176385 |  (2S,4R)-4-Methylglutamic acid | C6H11NO4 | 161.157 | 5 / 3 | -2.9 | Yes |
| 181436 |  CHEMBL466006 | C20H15N3O | 313.36 | 3 / 1 | 3.8 | Yes |
| 181714 |  ethyl 2-amino-4,5-diphenylthiophene-3-carboxylate | C19H17NO2S | 323.41 | 4 / 1 | 5.3 | No |
| 189221 |  MLS003171619 | C21H16ClN3O3 | 393.827 | 4 / 1 | 2.6 | Yes |
| 189234 |  CHEMBL2373733 | C21H16ClN3O3 | 393.827 | 4 / 1 | 2.6 | Yes |
| 563364 |  SIB 1757 | C12H11N3O | 213.24 | 4 / 1 | 3.0 | Yes |
| 563497 |  CHEMBL1098211 | C17H12N2O | 260.296 | 3 / 1 | 4.1 | Yes |
| 197738 |  3-((2-fluorothiazol-4-yl)ethynyl)-5-fluorobenzonitrile | C12H4F2N2S | 246.235 | 5 / 0 | 3.3 | Yes |
| 199219 |  1-Benzyl-APDC | C13H16N2O4 | 264.281 | 6 / 3 | -4.5 | Yes |
| 201024 |  Dcg-IV | C7H9NO6 | 203.15 | 7 / 4 | -4.3 | Yes |
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