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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Metabotropic glutamate receptor 6
Species	Homo sapiens (Human)
Gene	GRM6
Synonym	nob3 nob2 nerg1 mGluR6 mGlu6 receptor Gprc1f glutamate receptor nob4 [ Show all ]
Disease	N/A
Length	877
Amino acid sequence	MARPRRAREPLLVALLPLAWLAQAGLARAAGSVRLAGGLTLGGLFPVHARGAAGRACGQLKKEQGVHRLEAMLYALDRVNADPELLPGVRLGARLLDTCSRDTYALEQALSFVQALIRGRGDGDEVGVRCPGGVPPLRPAPPERVVAVVGASASSVSIMVANVLRLFAIPQISYASTAPELSDSTRYDFFSRVVPPDSYQAQAMVDIVRALGWNYVSTLASEGNYGESGVEAFVQISREAGGVCIAQSIKIPREPKPGEFSKVIRRLMETPNARGIIIFANEDDIRRVLEAARQANLTGHFLWVGSDSWGAKTSPILSLEDVAVGAITILPKRASIDGFDQYFMTRSLENNRRNIWFAEFWEENFNCKLTSSGTQSDDSTRKCTGEERIGRDSTYEQEGKVQFVIDAVYAIAHALHSMHQALCPGHTGLCPAMEPTDGRMLLQYIRAVRFNGSAGTPVMFNENGDAPGRYDIFQYQATNGSASSGGYQAVGQWAETLRLDVEALQWSGDPHEVPSSLCSLPCGPGERKKMVKGVPCCWHCEACDGYRFQVDEFTCEACPGDMRPTPNHTGCRPTPVVRLSWSSPWAAPPLLLAVLGIVATTTVVATFVRYNNTPIVRASGRELSYVLLTGIFLIYAITFLMVAEPGAAVCAARRLFLGLGTTLSYSALLTKTNRIYRIFEQGKRSVTPPPFISPTSQLVITFSLTSLQVVGMIAWLGARPPHSVIDYEEQRTVDPEQARGVLKCDMSDLSLIGCLGYSLLLMVTCTVYAIKARGVPETFNEAKPIGFTMYTTCIIWLAFVPIFFGTAQSAEKIYIQTTTLTVSLSLSASVSLGMLYVPKTYVILFHPEQNVQKRKRSLKATSTVAAPPKGEDAEAHK
UniProt	O15303
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4573
IUPHAR	294
DrugBank	N/A

Ligand

Name	(2S,3S)-3-(carboxymethyl)azetidine-2-carboxylic acid
Molecular formula	C6H9NO4
IUPAC name	(2S,3S)-3-(carboxymethyl)azetidine-2-carboxylic acid
Molecular weight	159.141
Hydrogen bond acceptor	5
Hydrogen bond donor	3
XlogP	-3.3
Synonyms	185387-36-4 CHEMBL314690 AC1MBZ39 RT-015851 (2S,3S)-3-Carboxymethyl-azetidine-2-carboxylic acid BDBM50288204 3-Azetidineacetic acid, 2-carboxy-, (2S,3S)- CTK8F0661 AJ-49899 ST50824727 (2S,3S)-trans-3-(Carboxymethyl)-azetidine-2-acetic Acid J-011895 AKOS022180391 ZINC4262470 [ Show all ]
Inchi Key	FQUPICCTRPWMDZ-UCORVYFPSA-N
Inchi ID	InChI=1S/C6H9NO4/c8-4(9)1-3-2-7-5(3)6(10)11/h3,5,7H,1-2H2,(H,8,9)(H,10,11)/t3-,5-/m0/s1
PubChem CID	2733519
ChEMBL	CHEMBL314690
IUPHAR	N/A
BindingDB	50288204
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<300000.0 nM	, Bioorg. Med. Chem. Lett., (1996) 6:21:2559	BindingDB,ChEMBL
Inhibition	0.0 %	Bioorg. Med. Chem. Lett., (1996) 6:21:2559	ChEMBL
Max response	17.0 %	Bioorg. Med. Chem. Lett., (1996) 6:21:2559	ChEMBL

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