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GPCR

Name	Metabotropic glutamate receptor 3
Species	Homo sapiens (Human)
Gene	GRM3
Synonym	GPRC1C mGluR3 mGlu3 receptor glutamate receptor
Disease	Alzheimer disease; Major depressive disorder Anxiety disorder Schizophrenia
Length	879
Amino acid sequence	MKMLTRLQVLTLALFSKGFLLSLGDHNFLRREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDDYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKVDEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAASRANASFTWVASDGWGAQESIIKGSEHVAYGAITLELASQPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLQNKRNHRRVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCDAMKILDGKKLYKDYLLKINFTAPFNPNKDADSIVKFDTFGDGMGRYNVFNFQNVGGKYSYLKVGHWAETLSLDVNSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYLADEFTCMDCGSGQWPTADLTGCYDLPEDYIRWEDAWAIGPVTIACLGFMCTCMVVTVFIKHNNTPLVKASGRELCYILLFGVGLSYCMTFFFIAKPSPVICALRRLGLGSSFAICYSALLTKTNCIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQIVMVSVWLILEAPGTRRYTLAEKRETVILKCNVKDSSMLISLTYDVILVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHIILFQPQKNVVTHRLHLNRFSVSGTGTTYSQSSASTYVPTVCNGREVLDSTTSSL
UniProt	Q14832
Protein Data Bank	3sm9, 6b7h, 4xar, 5cnk, 5cnm
GPCR-HGmod model	N/A
3D structure model	This structure is from PDB ID 3sm9.
BioLiP	BL0324562, BL0307715, BL0204618, BL0324563, BL0412294, BL0412295, BL0324561
Therapeutic Target Database	T02719
ChEMBL	CHEMBL2888
IUPHAR	291
DrugBank	N/A

Ligand

Name	L-AP4
Molecular formula	C4H10NO5P
IUPAC name	(2S)-2-amino-4-phosphonobutanoic acid
Molecular weight	183.1
Hydrogen bond acceptor	6
Hydrogen bond donor	4
XlogP	-5.5
Synonyms	J-014961 L-2-amino-4-phosphonobutiric acid NCGC00013365 NSC-30079 [3H]AP4 (2S)-2-amino-4-phosphonobutanoic acid 23052-81-5 BN0084 D0H7UP L-(+)-2-Amino-4-phosphono-butanoic acid L-APB NCGC00024468-01 SR-01000597692 (S)-2-amino-4-phosphonobutanoic acid ACM23052815 CCG-37553 FCH919870 L-1-amino-4-phosphonobutanoic acid MFCD00083244 NCIStruc1_000162 UNII-H8B59H10OK component DDOQBQRIEWHWBT-VKHMYHEASA-N 2-Amino-3-(3,5-dioxo-[1,2,4]oxadiazolidin-2-yl)-propionic acid B6202 CS-0020419 GTPL1412 l(+)-2-amino-4-phosphonobutanoic acid L-AP-4 NCGC00013365-02 S-2-amino-4-phosphonobutyrate (2S)-2-amino-4-phosphonobutanoic acid. Butanoic acid,2-amino-4-phosphono-,(2S)- D0PN6Z L-(+)-2-Amino-4-phosphonobutyric acid LS-46098 NCGC00024468-02 SR-01000597692-1 AKOS006239562 FT-0689296 L-150 MolPort-002-514-399 NCIStruc2_000128 ZINC2033983 2-Amino-4-phosphono-butyric acid(S-AP4) BDBM50007548 D08PBE HY-100781A L(+)-2-Amino-4-phosphonobutanoic acid (L-AP4) NCGC00013365-03 SCHEMBL1969235 (S)-2-Amino-4-phosphono-butyric acid AC1L456H C-55169 E7P L-(+)-2-Amino-4-phosphonobutyric acid, optical purity optical purity: >=95% (HPLC, Marfey's reagent) M01257 NCI30079 Tocris-0103 B6200 CHEMBL33567 GTPL1410 [ Show all ]
Inchi Key	DDOQBQRIEWHWBT-VKHMYHEASA-N
Inchi ID	InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)/t3-/m0/s1
PubChem CID	179394
ChEMBL	CHEMBL33567
IUPHAR	1410, 1412
BindingDB	50007548
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<1000000.0 nM	PMID10893301	BindingDB,ChEMBL

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