You can:
| Name | Metabotropic glutamate receptor 3 |
|---|---|
| Species | Homo sapiens (Human) |
| Gene | GRM3 |
| Synonym | GPRC1C mGluR3 mGlu3 receptor glutamate receptor |
| Disease | Alzheimer disease; Major depressive disorder Anxiety disorder Schizophrenia |
| Length | 879 |
| Amino acid sequence | MKMLTRLQVLTLALFSKGFLLSLGDHNFLRREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDDYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKVDEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAASRANASFTWVASDGWGAQESIIKGSEHVAYGAITLELASQPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLQNKRNHRRVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCDAMKILDGKKLYKDYLLKINFTAPFNPNKDADSIVKFDTFGDGMGRYNVFNFQNVGGKYSYLKVGHWAETLSLDVNSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYLADEFTCMDCGSGQWPTADLTGCYDLPEDYIRWEDAWAIGPVTIACLGFMCTCMVVTVFIKHNNTPLVKASGRELCYILLFGVGLSYCMTFFFIAKPSPVICALRRLGLGSSFAICYSALLTKTNCIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQIVMVSVWLILEAPGTRRYTLAEKRETVILKCNVKDSSMLISLTYDVILVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHIILFQPQKNVVTHRLHLNRFSVSGTGTTYSQSSASTYVPTVCNGREVLDSTTSSL |
| UniProt | Q14832 |
| Protein Data Bank | 3sm9, 6b7h, 4xar, 5cnk, 5cnm |
| GPCR-HGmod model | N/A |
| 3D structure model | This structure is from PDB ID 3sm9. |
| BioLiP | BL0324562, BL0307715, BL0204618, BL0324563, BL0412294, BL0412295, BL0324561 |
| Therapeutic Target Database | T02719 |
| ChEMBL | CHEMBL2888 |
| IUPHAR | 291 |
| DrugBank | N/A |
You can:
| GLASS ID | Molecule | Formula | Molecular weight | H-bond acceptor / donor | XlogP | Lipinski's druglikeness |
|---|---|---|---|---|---|---|
| 535925 |  CHEMBL3977508 | C18H17Cl2N3O5S | 458.31 | 8 / 4 | -0.5 | Yes |
| 680 |  CHEMBL2111822 | C15H19NO6S | 341.378 | 7 / 3 | -2.1 | Yes |
| 535966 |  CHEMBL3913414 | C17H18Cl2N2O6 | 417.239 | 7 / 4 | -1.9 | Yes |
| 4840 |  BDBM50332632 | C17H13ClN2O3 | 328.752 | 4 / 1 | 2.8 | Yes |
| 536130 |  CHEMBL3899832 | C22H19N5O4 | 417.425 | 8 / 2 | 3.6 | Yes |
| 8267 |  CHEMBL2208408 | C15H15ClN2O3S | 338.806 | 4 / 1 | 2.6 | Yes |
| 10402 |  CHEMBL2426616 | C14H14N2O2S | 274.338 | 4 / 0 | 2.3 | Yes |
| 11483 |  CHEMBL2381648 | C10H14N2O5 | 242.231 | 6 / 4 | -4.2 | Yes |
| 11488 |  CHEMBL2381649 | C10H14N2O5 | 242.231 | 6 / 4 | -4.2 | Yes |
| 13322 |  QUISQUALIC ACID | C5H7N3O5 | 189.127 | 6 / 3 | -3.9 | Yes |
| 13330 |  2-amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl)propanoic acid | C5H7N3O5 | 189.127 | 6 / 3 | -3.9 | Yes |
| 15207 |  635318-11-5 | C7H9NO6S | 235.21 | 7 / 3 | -4.8 | Yes |
| 24449 |  CHEMBL2381647 | C8H12N2O4 | 200.194 | 6 / 4 | -6.7 | Yes |
| 24455 |  CHEMBL2381646 | C8H12N2O4 | 200.194 | 6 / 4 | -6.7 | Yes |
| 25223 |  CHEMBL2111822 | C15H21NO7S | 359.393 | 8 / 4 | N/A | N/A |
| 27356 |  CHEMBL2112579 | C8H13NO4 | 187.195 | 5 / 3 | -2.7 | Yes |
| 30707 |  CHEMBL365368 | C9H13NO4 | 199.206 | 5 / 3 | -2.8 | Yes |
| 30711 |  CHEMBL195500 | C9H13NO4 | 199.206 | 5 / 3 | -2.8 | Yes |
| 30713 |  LY 395756 | C9H13NO4 | 199.206 | 5 / 3 | -2.8 | Yes |
| 30785 |  CHEMBL2385894 | C16H21BrCl2N4O4S | 516.232 | 8 / 3 | N/A | No |
| 35423 |  CHEMBL418462 | C13H15ClN2O4 | 298.723 | 6 / 3 | -3.9 | Yes |
| 35542 |  CHEMBL2112634 | C15H17NO6 | 307.302 | 7 / 4 | -1.8 | Yes |
| 35786 |  BDBM50388941 | C16H13N3O3 | 295.298 | 5 / 1 | 1.4 | Yes |
| 467497 |  CHEMBL3605296 | C20H17N5O3 | 375.388 | 6 / 1 | 2.1 | Yes |
| 522651 |  CHEMBL3746344 | C20H18FN3O2 | 351.381 | 4 / 0 | 3.3 | Yes |
| 45063 |  CHEMBL104296 | C20H20N2O3S | 368.451 | 5 / 0 | 3.4 | Yes |
| 548412 |  CHEMBL3953570 | C15H16ClNO6 | 341.744 | 7 / 4 | -2.5 | Yes |
| 46261 |  CHEMBL1169414 | C19H20N2O4 | 340.379 | 6 / 3 | -2.8 | Yes |
| 522870 |  CHEMBL3746457 | C18H15FN4O2 | 338.342 | 5 / 0 | 2.2 | Yes |
| 469266 |  CHEMBL3628115 | C19H12ClN3O4 | 381.772 | 5 / 1 | 2.6 | Yes |
| 53136 |  CHEMBL1688377 | C18H25N3OS | 331.478 | 4 / 0 | 3.3 | Yes |
| 55710 |  CHEMBL1830707 | C14H13N5S | 283.353 | 5 / 2 | 2.8 | Yes |
| 469955 |  CHEMBL3628112 | C20H12Cl2N2O4 | 415.226 | 4 / 1 | 4.3 | Yes |
| 57287 |  L-AP4 | C4H10NO5P | 183.1 | 6 / 4 | -5.5 | Yes |
| 61161 |  CHEMBL334014 | C8H10FNO4 | 203.169 | 6 / 3 | -3.2 | Yes |
| 553567 |  (S)-MCPG | C10H11NO4 | 209.201 | 5 / 3 | -2.0 | Yes |
| 64223 |  (RS)-MCPG | C10H11NO4 | 209.201 | 5 / 3 | -2.0 | Yes |
| 70682 |  LY307452 | C21H25NO4 | 355.434 | 5 / 3 | 1.4 | Yes |
| 80650 |  CHEMBL1783985 | C15H25NO | 235.371 | 1 / 0 | 3.4 | Yes |
| 473332 |  CHEMBL3603923 | C16H8ClFN4 | 310.716 | 5 / 0 | 2.9 | Yes |
| 85545 |  CHEMBL332141 | C11H17NO4 | 227.26 | 5 / 3 | -1.6 | Yes |
| 524131 |  CHEMBL3804910 | C23H35N5O3 | 429.565 | 5 / 0 | 3.7 | Yes |
| 96472 |  2-(m-tolylethynyl)pyrimidine | C13H10N2 | 194.237 | 2 / 0 | 2.6 | Yes |
| 524406 |  CHEMBL3745812 | C19H15F2N3O2 | 355.345 | 5 / 0 | 3.0 | Yes |
| 99227 |  CHEMBL333519 | C8H10FNO4 | 203.169 | 6 / 3 | -3.0 | Yes |
| 553775 |  D0N9UZ | C12H13N5O6 | 323.265 | 8 / 5 | -4.7 | Yes |
| 105939 |  CHEMBL333771 | C14H16ClNO4 | 297.735 | 5 / 3 | -0.7 | Yes |
| 109302 |  (2S,1'S,2'S)-2-(carboxycyclopropyl)glycine | C6H9NO4 | 159.141 | 5 / 3 | -3.4 | Yes |
| 555895 |  CHEMBL285369 | C6H9NO4 | 159.141 | 5 / 3 | -3.4 | Yes |
| 115055 |  CHEMBL2204439 | C21H21NO3 | 335.403 | 3 / 1 | 3.2 | Yes |
| 477082 |  CHEMBL3628113 | C20H12ClFN2O4 | 398.774 | 5 / 1 | 3.8 | Yes |
| 477094 |  CHEMBL3616856 | C11H11F3N4O4S | 352.288 | 11 / 4 | -2.0 | No |
| 477097 |  CHEMBL3616849 | C11H11F3N4O4S | 352.288 | 11 / 4 | -2.0 | No |
| 524871 |  CHEMBL3804846 | C22H14F2N2O2 | 376.363 | 5 / 1 | 3.9 | Yes |
| 446358 |  CTK0H1302 | C6H9NO4 | 159.141 | 5 / 3 | -3.7 | Yes |
| 446366 |  CHEMBL3347670 | C6H9NO4 | 159.141 | 5 / 3 | -3.7 | Yes |
| 477914 |  CHEMBL3616857 | C11H12F2N4O4S | 334.298 | 10 / 4 | -2.3 | Yes |
| 477916 |  CHEMBL3616850 | C11H12F2N4O4S | 334.298 | 10 / 4 | -2.3 | Yes |
| 123322 |  CHEMBL2112580 | C17H20N2O4 | 316.357 | 5 / 3 | -1.2 | Yes |
| 525130 |  CHEMBL3806176 | C21H26N4O | 350.466 | 3 / 0 | 4.3 | Yes |
| 127113 |  CHEMBL1830711 | C13H12N6S | 284.341 | 6 / 2 | 2.1 | Yes |
| 128315 |  CHEMBL2204444 | C23H25NO2 | 347.458 | 3 / 0 | 4.5 | Yes |
| 549569 |  CHEMBL3890112 | C15H15ClFNO6 | 359.734 | 8 / 4 | -2.4 | Yes |
| 133595 |  CHEMBL61281 | C17H18N2O4 | 314.341 | 6 / 3 | -3.3 | Yes |
| 136667 |  CHEMBL292553 | C14H18N2O4 | 278.308 | 6 / 3 | -4.1 | Yes |
| 479862 |  CHEMBL3616859 | C13H18N4O4S | 326.371 | 8 / 4 | -1.8 | Yes |
| 479863 |  CHEMBL3616852 | C13H18N4O4S | 326.371 | 8 / 4 | -1.8 | Yes |
| 140048 |  Ibotenic acid | C5H6N2O4 | 158.113 | 5 / 3 | -3.9 | Yes |
| 140164 |  CHEMBL341457 | C15H19NO5 | 293.319 | 6 / 3 | -1.3 | Yes |
| 142520 |  CHEMBL2204440 | C22H21NO4 | 363.413 | 4 / 1 | 3.4 | Yes |
| 142521 |  CHEMBL2204441 | C22H21NO4 | 363.413 | 4 / 1 | 3.4 | Yes |
| 147380 |  CHEMBL90501 | C8H11NO4 | 185.179 | 5 / 3 | -3.2 | Yes |
| 158292 |  (RS)-PPG | C8H10NO5P | 231.144 | 6 / 4 | -3.7 | Yes |
| 549941 |  CHEMBL3971347 | C15H16ClNO6 | 341.744 | 7 / 4 | -2.5 | Yes |
| 540172 |  CHEMBL3956934 | C15H15ClFNO4 | 327.736 | 6 / 3 | -0.6 | Yes |
| 164944 |  CHEMBL124501 | C15H19NO4 | 277.32 | 5 / 3 | -0.9 | Yes |
| 167546 |  MGS-0028 | C8H8FNO5 | 217.152 | 7 / 3 | -4.2 | Yes |
| 550086 |  CHEMBL3955458 | C15H17NO6 | 307.302 | 7 / 4 | -3.2 | Yes |
| 175023 |  CHEMBL123842 | C14H18N2O4 | 278.308 | 6 / 4 | -2.0 | Yes |
| 179639 |  CHEMBL304919 | C20H22N2O4 | 354.406 | 6 / 3 | -2.6 | Yes |
| 183153 |  CHEMBL304034 | C19H20N2O4 | 340.379 | 6 / 3 | -2.9 | Yes |
| 540733 |  CHEMBL3885379 | C21H19ClF3N3O | 421.848 | 6 / 0 | 6.2 | No |
| 185815 |  MGS-0039 | C15H14Cl2FNO5 | 378.177 | 7 / 3 | -0.7 | Yes |
| 187015 |  CHEMBL140197 | C6H9NO5 | 175.14 | 6 / 4 | -3.9 | Yes |
| 187022 |  CHEMBL357043 | C6H9NO5 | 175.14 | 6 / 4 | -3.9 | Yes |
| 563360 |  SIB 1757 | C12H11N3O | 213.24 | 4 / 1 | 3.0 | Yes |
| 192704 |  CHEMBL1682820 | C16H14O3 | 254.285 | 3 / 0 | 2.8 | Yes |
| 195660 |  CHEMBL40123 | C19H21NO4 | 327.38 | 5 / 3 | 0.3 | Yes |
| 196048 |  CHEMBL2112583 | C18H19NO4 | 313.353 | 5 / 3 | -0.1 | Yes |
| 199216 |  1-Benzyl-APDC | C13H16N2O4 | 264.281 | 6 / 3 | -4.5 | Yes |
| 199680 |  Ro-4491533 | C24H20F3N3O | 423.439 | 6 / 1 | 5.0 | Yes |
| 201017 |  Dcg-IV | C7H9NO6 | 203.15 | 7 / 4 | -4.3 | Yes |
| 201029 |  2-(2,3-Dicarboxycyclopropyl)glycine | C7H9NO6 | 203.15 | 7 / 4 | -4.3 | Yes |
| 201223 |  CHEMBL90675 | C21H21NO5 | 367.401 | 6 / 3 | 0.6 | Yes |
| 201226 |  CHEMBL325140 | C21H21NO5 | 367.401 | 6 / 3 | 0.6 | Yes |
| 206364 |  CHEMBL1830698 | C13H11N5S | 269.326 | 5 / 2 | 2.4 | Yes |
| 207197 |  CHEMBL297150 | C6H11N3O4 | 189.171 | 7 / 4 | -6.2 | Yes |
| 208553 |  7-(benzyloxy)-2,3-dihydro-4H-chromen-4-one | C16H14O3 | 254.285 | 3 / 0 | 2.8 | Yes |
| 211178 |  CHEMBL2112586 | C18H27NO4 | 321.417 | 5 / 3 | 0.5 | Yes |
| 212451 |  CHEMBL61964 | C13H15ClN2O4 | 298.723 | 6 / 3 | -3.9 | Yes |
zhanglab
zhanggroup.org | +65-6601-1241 | Computing 1, 13 Computing Drive, Singapore 117417