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GLASS

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GPCR

Name	Metabotropic glutamate receptor 3
Species	Homo sapiens (Human)
Gene	GRM3
Synonym	GPRC1C mGluR3 mGlu3 receptor glutamate receptor
Disease	Alzheimer disease; Major depressive disorder Anxiety disorder Schizophrenia
Length	879
Amino acid sequence	MKMLTRLQVLTLALFSKGFLLSLGDHNFLRREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDDYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKVDEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAASRANASFTWVASDGWGAQESIIKGSEHVAYGAITLELASQPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLQNKRNHRRVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCDAMKILDGKKLYKDYLLKINFTAPFNPNKDADSIVKFDTFGDGMGRYNVFNFQNVGGKYSYLKVGHWAETLSLDVNSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYLADEFTCMDCGSGQWPTADLTGCYDLPEDYIRWEDAWAIGPVTIACLGFMCTCMVVTVFIKHNNTPLVKASGRELCYILLFGVGLSYCMTFFFIAKPSPVICALRRLGLGSSFAICYSALLTKTNCIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQIVMVSVWLILEAPGTRRYTLAEKRETVILKCNVKDSSMLISLTYDVILVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHIILFQPQKNVVTHRLHLNRFSVSGTGTTYSQSSASTYVPTVCNGREVLDSTTSSL
UniProt	Q14832
Protein Data Bank	3sm9, 6b7h, 4xar, 5cnk, 5cnm
GPCR-HGmod model	N/A
3D structure model	This structure is from PDB ID 3sm9.
BioLiP	BL0324562, BL0307715, BL0204618, BL0324563, BL0412294, BL0412295, BL0324561
Therapeutic Target Database	T02719
ChEMBL	CHEMBL2888
IUPHAR	291
DrugBank	N/A

Ligand

Name	SIB 1757
Molecular formula	C12H11N3O
IUPAC name	6-methyl-2-phenyldiazenylpyridin-3-ol
Molecular weight	213.24
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	3.0
Synonyms	AC1OBJF8 CCG-205235 D0Q6VH J-018594 NCGC00025047-01 SCHEMBL10160623 SR-01000076142-1 3-Pyridinol, 6-methyl-2-(phenylazo)- 6-methyl-2-(phenylhydrazinylidene)pyridin-3-one BC600132 CHEMBL1427311 GTPL1431 Lopac0_001161 NCGC00025047-04 SIB 1757, >=99% (HPLC), crystalline Tox21_501161 (2E)-6-methyl-2-(phenylhydrazinylidene)pyridin-3-one AC1O3ID7 BRD-K98157055-001-04-2 CTK1B2569 HMS3267D07 MolPort-003-959-633 NSC_5218788 SMR000326907 ZINC18155387 31993-01-8 AKOS024456470 CHEBI:93722 DTXSID00425754 L000560 NCGC00025047-02 SCHEMBL179770 SR-01000076142-3 6-methyl-2-[(E)-phenyldiazenyl]pyridin-3-ol BDBM86717 CHEMBL405358 HMS2231C22 LP01161 NCGC00185991-01 SIB-1757 ZINC100001934 (2Z)-6-methyl-2-(phenylhydrazinylidene)pyridin-3-one AC1O44IY CAS_5218788 D05TFE HMS3369P05 NCGC00015978-01 S 9186 SR-01000076142 3-Pyridinol, 6-methyl-2-(2-phenyldiazenyl)- 6-Methyl-2-(phenylazo)-3-pyridinol B6636 EU-0101161 Lopac-S-9186 NCGC00025047-03 Tocris-1215 BN0481 CHEMBL88553 HMS3263J03 MLS000860049 NCGC00261846-01 SIB1757 ZINC13557614 (E)-6-methyl-2-(phenyldiazenyl)pyridin-3-ol [ Show all ]
Inchi Key	LOCPVWIREQIGNQ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C12H11N3O/c1-9-7-8-11(16)12(13-9)15-14-10-5-3-2-4-6-10/h2-8,16H,1H3
PubChem CID	5218788
ChEMBL	CHEMBL1427311
IUPHAR	N/A
BindingDB	86717
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<100000.0 nM	PMID10893301	BindingDB

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