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GPCR

NameMetabotropic glutamate receptor 3
SpeciesHomo sapiens (Human)
GeneGRM3
SynonymGPRC1C
mGluR3
mGlu3 receptor
glutamate receptor
DiseaseAlzheimer disease; Major depressive disorder
Anxiety disorder
Schizophrenia
Length879
Amino acid sequenceMKMLTRLQVLTLALFSKGFLLSLGDHNFLRREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDDYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKVDEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAASRANASFTWVASDGWGAQESIIKGSEHVAYGAITLELASQPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLQNKRNHRRVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCDAMKILDGKKLYKDYLLKINFTAPFNPNKDADSIVKFDTFGDGMGRYNVFNFQNVGGKYSYLKVGHWAETLSLDVNSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYLADEFTCMDCGSGQWPTADLTGCYDLPEDYIRWEDAWAIGPVTIACLGFMCTCMVVTVFIKHNNTPLVKASGRELCYILLFGVGLSYCMTFFFIAKPSPVICALRRLGLGSSFAICYSALLTKTNCIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQIVMVSVWLILEAPGTRRYTLAEKRETVILKCNVKDSSMLISLTYDVILVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHIILFQPQKNVVTHRLHLNRFSVSGTGTTYSQSSASTYVPTVCNGREVLDSTTSSL
UniProtQ14832
Protein Data Bank3sm9, 6b7h, 4xar, 5cnk, 5cnm
GPCR-HGmod modelN/A
3D structure modelThis structure is from PDB ID 3sm9.
BioLiPBL0324562, BL0307715, BL0204618, BL0324563, BL0412294, BL0412295, BL0324561
Therapeutic Target DatabaseT02719
ChEMBLCHEMBL2888
IUPHAR291
DrugBankN/A

Ligand

NameCHEMBL341457
Molecular formulaC15H19NO5
IUPAC name(1S)-2-[(1R)-1-amino-1-carboxy-3-(3-methoxyphenyl)propyl]cyclopropane-1-carboxylic acid
Molecular weight293.319
Hydrogen bond acceptor6
Hydrogen bond donor3
XlogP-1.3
SynonymsBDBM50062534
(S)-2-[(R)-1-Amino-1-carboxy-3-(3-methoxy-phenyl)-propyl]-cyclopropanecarboxylic acid
Inchi KeyIRMXEKLCWFUGDP-CPNOVKFWSA-N
Inchi IDInChI=1S/C15H19NO5/c1-21-10-4-2-3-9(7-10)5-6-15(16,14(19)20)12-8-11(12)13(17)18/h2-4,7,11-12H,5-6,8,16H2,1H3,(H,17,18)(H,19,20)/t11-,12?,15+/m0/s1
PubChem CID44348939
ChEMBLCHEMBL341457
IUPHARN/A
BindingDB50062534
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50160.0 nMPMID9464367BindingDB,ChEMBL

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