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GPCR

Name	Metabotropic glutamate receptor 3
Species	Homo sapiens (Human)
Gene	GRM3
Synonym	GPRC1C mGluR3 mGlu3 receptor glutamate receptor
Disease	Alzheimer disease; Major depressive disorder Anxiety disorder Schizophrenia
Length	879
Amino acid sequence	MKMLTRLQVLTLALFSKGFLLSLGDHNFLRREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDDYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKVDEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAASRANASFTWVASDGWGAQESIIKGSEHVAYGAITLELASQPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLQNKRNHRRVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCDAMKILDGKKLYKDYLLKINFTAPFNPNKDADSIVKFDTFGDGMGRYNVFNFQNVGGKYSYLKVGHWAETLSLDVNSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYLADEFTCMDCGSGQWPTADLTGCYDLPEDYIRWEDAWAIGPVTIACLGFMCTCMVVTVFIKHNNTPLVKASGRELCYILLFGVGLSYCMTFFFIAKPSPVICALRRLGLGSSFAICYSALLTKTNCIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQIVMVSVWLILEAPGTRRYTLAEKRETVILKCNVKDSSMLISLTYDVILVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHIILFQPQKNVVTHRLHLNRFSVSGTGTTYSQSSASTYVPTVCNGREVLDSTTSSL
UniProt	Q14832
Protein Data Bank	3sm9, 6b7h, 4xar, 5cnk, 5cnm
GPCR-HGmod model	N/A
3D structure model	This structure is from PDB ID 3sm9.
BioLiP	BL0324562, BL0307715, BL0204618, BL0324563, BL0412294, BL0412295, BL0324561
Therapeutic Target Database	T02719
ChEMBL	CHEMBL2888
IUPHAR	291
DrugBank	N/A

Ligand

Name	(S)-MCPG
Molecular formula	C10H11NO4
IUPAC name	4-[(1S)-1-amino-1-carboxyethyl]benzoic acid
Molecular weight	209.201
Hydrogen bond acceptor	5
Hydrogen bond donor	3
XlogP	-2.0
Synonyms	Lopac-M-4796 NCGC00024543-02 Tocris-0337 (+)-alpha-Methyl-4-carboxyphenylglycine (S)-4-(1-amino-1-carboxyethyl)benzoic acid Benzeneacetic acid, alpha-amino-4-carboxy-alpha-methyl-, (alphaS)- D06ALU MolPort-003-958-661 S(+)-\|A-Amino-4-carboxy-\|A-methyl-benzeneacetic acid ZINC2559035 (+)-\|A-Methyl-4-carboxyphenylglycine AKOS024457587 CHEBI:43876 DB04256 NCGC00024542-01 SR-01000597608-1 (S)-(+)-alpha-methyl-4-carboxyphenylglycine 4-[(1S)-1-amino-1-carboxyethyl]benzoic acid alpha-Methyl-cpgly CS-5944 HY-100406 MCG RT-005746 UNII-61F6J48NHR (+)-alpha-Methyl-4-carboxyphenylglycine, solid (S)-?-Methyl-4-carboxyphenylglycine 61F6J48NHR Benzeneacetic acid,a-amino-4-carboxy-a-methyl-,(as)- D0J8OW NCGC00015676-01 SCHEMBL12648649 (R,S)-MCPG alpha-Mcpg DTXSID2042567 J-008664 NCGC00024543-01 Tocris-0336 (S)-(ALPHA)-METHYL-4-CARBOXYPHENYLGLYCINE 4-[(2S)-2-amino-1-hydroxy-1-oxopropan-2-yl]benzoic acid BDBM50212325 CTK8F0682 MFCD00216858 S(+)-alpha-Amino-4-carboxy-alpha-methyl-benzeneacetic acid UNII-7HJ67IIE31 component DNCAZYRLRMTVSF-JTQLQIEISA-N (+)-MCPG (S)-a-methyl-4-carboxyphenylglycine AC1L9JKC BN0323 NCGC00015676-02 SR-01000597608 (S)-(+)-alpha-amino-4-carboxy-2-methylbenzeneacetic 4-(1-AMINO-1-CARBOXY-ETHYL)-BENZOIC ACID alpha-Methyl-4-carboxyphenylglycine CHEMBL257626 GTPL1373 [ Show all ]
Inchi Key	DNCAZYRLRMTVSF-JTQLQIEISA-N
Inchi ID	InChI=1S/C10H11NO4/c1-10(11,9(14)15)7-4-2-6(3-5-7)8(12)13/h2-5H,11H2,1H3,(H,12,13)(H,14,15)/t10-/m0/s1
PubChem CID	446355
ChEMBL	CHEMBL257626
IUPHAR	1373
BindingDB	50212325
DrugBank	DB04256
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	158489.0 nM	PMID10530814	IUPHAR

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