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GLASS

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GPCR

Name	Metabotropic glutamate receptor 8
Species	Homo sapiens (Human)
Gene	GRM8
Synonym	mGluR8b mGluR8 mGlu8 receptor Gprc1h glutamate receptor GLUR8 [ Show all ]
Disease	N/A
Length	908
Amino acid sequence	MVCEGKRSASCPCFFLLTAKFYWILTMMQRTHSQEYAHSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQLHLKVEDMQWAHREHTHPASVCSLPCKPGERKKTVKGVPCCWHCERCEGYNYQVDELSCELCPLDQRPNMNRTGCQLIPIIKLEWHSPWAVVPVFVAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFLMIAAPDTIICSFRRVFLGLGMCFSYAALLTKTNRIHRIFEQGKKSVTAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPHIIIDYGEQRTLDPEKARGVLKCDISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQKRKRSFKAVVTAATMQSKLIQKGNDRPNGEVKSELCESLETNTSSTKTTYISYSNHSI
UniProt	O00222
Protein Data Bank	6bsz, 6bt5, 6e5v
GPCR-HGmod model	N/A
3D structure model	This structure is from PDB ID 6bsz.
BioLiP	BL0432251,BL0432252, BL0403876,BL0403877, BL0403874,BL0403875
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3228
IUPHAR	296
DrugBank	BE0000835

Ligand

Name	2-amino-4-phosphonobutanoic acid
Molecular formula	C4H10NO5P
IUPAC name	2-amino-4-phosphonobutanoic acid
Molecular weight	183.1
Hydrogen bond acceptor	6
Hydrogen bond donor	4
XlogP	-5.5
Synonyms	NCGC00024466-02 NSC30079 (+/-)-2-Amino-4-phosphonobutyric acid, solid SR-01000075414-3 AC1Q6RPJ Butanoic acid, 2-amino-4-phosphono- (9CI) DDOQBQRIEWHWBT-UHFFFAOYSA-N FT-0625388 L -AP4 LP00064 NCGC00260749-01 ( inverted exclamation markA)-AP-4 PDSP1_000818 (y)-2-Amino-4-phosphonobutyric acid 4-Amino Phosphonobutyrate AM807295 CCG-204159 DL-2-Amino-4-phosphonobutanoic acid (AP4) I04-1589 L-2-amino-4-phosphonobutanoic acid MolPort-002-513-394 NCGC00015041-05 NSC-30079 (+/-)-2-AMINO-4-PHOSPHONO-BUTYRIC ACID SR-01000075414 2-Amino-4-phosphono-butyric acid Abu(P) BRN 5255932 CTK5B8255 EU-0100064 KS-000024GC L000344 NCGC00024466-03 NSC354086 (+/-)-AP-4 Tox21_500064 2-Amino-4-phosphonobutyric acid ACM20263074 BUTYRIC ACID, 2-AMINO-4-PHOSPHONO- DL-0710 GlcN-6-P synthase inhibitor, 1 (racemic mixture) L-(+)-2-AMINO-4-PHOSPHONO-BUTYRIC ACID LS-47843 NCI60_002523 ( inverted question mark)-2-Amino-4-phosphonobutyric acid PDSP2_000805 BDBM50004051 DL-2-Amino-4-phosphonobutyric acid IN1534 L-2-amino-4-phosphonobutyrate NCGC00015041-03 NCGC00015041-06 NSC-354086 (+/-)-2-Amino-4-phosphonobutyric acid SR-01000075414-1 2-Amino-4-phosphono-butyric acid (AP4) AC1L1D5X Butanoic acid, 2-amino-4-phosphono- D00IGI FCH1114914 L -(+)-2-Amino-4-phosphono- butanoic acid Lopac0_000064 NCGC00024466-04 OR311226 (?)-2-Amino-4-phosphonobutyric acid 20263-07-4 AKOS015892998 C-51648 DL-2-Amino-4-phosphono-butanoic acid HMS3260M09 L-2-amino-4-phosphobutyric acid MFCD00013999 NSC 30079 ( inverted question mark)-AP-4 SCHEMBL56139 2 APB 6323-99-5 BN0082 CHEMBL285843 DL-AP4 J-013164 L-AP4 cpd, butyric NCGC00015041-04 [ Show all ]
Inchi Key	DDOQBQRIEWHWBT-UHFFFAOYSA-N
Inchi ID	InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)
PubChem CID	2207
ChEMBL	CHEMBL285843
IUPHAR	N/A
BindingDB	50004051
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	5.1 nM	PMID15603952	BindingDB,ChEMBL
Ki	400.0 nM	PMID9131252	PDSP,BindingDB

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