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GLASS

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GPCR

Name	Metabotropic glutamate receptor 8
Species	Homo sapiens (Human)
Gene	GRM8
Synonym	mGluR8b mGluR8 mGlu8 receptor Gprc1h glutamate receptor GLUR8 [ Show all ]
Disease	N/A
Length	908
Amino acid sequence	MVCEGKRSASCPCFFLLTAKFYWILTMMQRTHSQEYAHSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQLHLKVEDMQWAHREHTHPASVCSLPCKPGERKKTVKGVPCCWHCERCEGYNYQVDELSCELCPLDQRPNMNRTGCQLIPIIKLEWHSPWAVVPVFVAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFLMIAAPDTIICSFRRVFLGLGMCFSYAALLTKTNRIHRIFEQGKKSVTAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPHIIIDYGEQRTLDPEKARGVLKCDISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQKRKRSFKAVVTAATMQSKLIQKGNDRPNGEVKSELCESLETNTSSTKTTYISYSNHSI
UniProt	O00222
Protein Data Bank	6bsz, 6bt5, 6e5v
GPCR-HGmod model	N/A
3D structure model	This structure is from PDB ID 6bsz.
BioLiP	BL0432251,BL0432252, BL0403876,BL0403877, BL0403874,BL0403875
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3228
IUPHAR	296
DrugBank	BE0000835

Ligand

Name	MPEP
Molecular formula	C14H11N
IUPAC name	2-methyl-6-(2-phenylethynyl)pyridine
Molecular weight	193.249
Hydrogen bond acceptor	1
Hydrogen bond donor	0
XlogP	3.3
Synonyms	NCGC00025044-03 UNII-7VC0YVI27Y 2-methyl-6-(2-phenylethynyl)pyridine AM81262 CS-0794 HY-14609A NCGC00015682-03 s2809 ZX-AN014840 2-Methyl-6-(phenylethynyl)pyridine 7VC0YVI27Y BRD-K60690191-003-02-1 DB-014655 Lopac-M-5435 NCGC00025044-01 SW219533-1 2-Picoline, 6-phenylethynyl- AC1MHGB1 GTPL1426 MLS006011229 Pyridine, 2-methyl-6-(2-phenylethynyl)- Y0463 2-methyl-6-(phenyl-ethynyl)pyridine 6-methyl-2-(2-phenylethynyl)pyridine BCP05962 D0IO8J KB-78955 NCGC00015682-01 NCGC00015682-04 SCHEMBL103061 [3H]-2-methyl-6-(phenylethynyl)-pyridine 2-Methyl-6-phenylethynyl-pyridine 96206-92-7 CCG-204823 DTXSID9043982 Lopac0_000738 NCGC00025044-02 Tocris-1212 2151AH AKOS006275850 CHEMBL66654 HMS3651F13 MolPort-003-958-770 NCGC00015682-02 Pyridine, 2-methyl-6-(phenylethynyl)- ZINC2581406 2-methyl-6-(phenylethynyl)-pyridine 6-Methyl-2-(phenylethynyl)pyridine BDBM50084137 D0R8TZ L000408 NCGC00015682-05 SMR004702989 2-Methyl-6-phenylethynyl-pyridine(MPEP) AB0035962 CHEBI:64159 F2167-5303 LS-131827 [ Show all ]
Inchi Key	NEWKHUASLBMWRE-UHFFFAOYSA-N
Inchi ID	InChI=1S/C14H11N/c1-12-6-5-9-14(15-12)11-10-13-7-3-2-4-8-13/h2-9H,1H3
PubChem CID	3025961
ChEMBL	CHEMBL66654
IUPHAR	1426
BindingDB	50084137
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<100000.0 nM	PMID10893301	BindingDB,ChEMBL

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