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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	DFMTI
Molecular formula	C20H18F2N4O
IUPAC name	5-[1-(2,4-difluorophenyl)-5-methyltriazol-4-yl]-2-propan-2-yl-3H-isoindol-1-one
Molecular weight	368.388
Hydrogen bond acceptor	5
Hydrogen bond donor	0
XlogP	3.4
Synonyms	CS-5849 M-265 5-[1-(2,4-difluorophenyl)-5-methyltriazol-4-yl]-2-propan-2-yl-3H-isoindol-1-one. 864864-86-8 GTPL6335 SCHEMBL1500017 KS-00001CM3 5-(1-(2,4-difluorophenyl)-5-methyl-1H-1,2,3-triazol-4-yl)-2-isopropylisoindolin-1-one D0OS8Y MK-5435 AKOS032944969 HY-100404 ZINC13983201 2-Isopropyl-5-[1-(2,4-difluorophenyl)-5-methyl-1H-1,2,3-triazole-4-yl]isoindoline-1-one CHEMBL579062 L023906 5-[1-(2,4-difluorophenyl)-5-methyltriazol-4-yl]-2-propan-2-yl-3H-isoindol-1-one MolPort-044-724-496 BDBM50301804 KKZVYGIANGOHBS-UHFFFAOYSA-N 4-(2-isopropyl-1-oxo-isoindoline-5-yl)-1-(2,4-difluorophenyl)-5-methyl-1H-[1,2,3]triazole [ Show all ]
Inchi Key	KKZVYGIANGOHBS-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H18F2N4O/c1-11(2)25-10-14-8-13(4-6-16(14)20(25)27)19-12(3)26(24-23-19)18-7-5-15(21)9-17(18)22/h4-9,11H,10H2,1-3H3
PubChem CID	15985251
ChEMBL	CHEMBL579062
IUPHAR	6335
BindingDB	50301804
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
171714	Metabotropic glutamate receptor 1	Q13255	GRM1	Homo sapiens (Human)	1194
171717	Metabotropic glutamate receptor 1	P23385	Grm1	Rattus norvegicus (Rat)	1199
171716	Metabotropic glutamate receptor 2	Q14416	GRM2	Homo sapiens (Human)	872
171715	Metabotropic glutamate receptor 8	O00222	GRM8	Homo sapiens (Human)	908

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