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Name | 5-hydroxytryptamine receptor 2A |
---|---|
Species | Bos taurus (Bovine) |
Gene | HTR2A |
Synonym | 5-HT-2 5-HT-2A Serotonin receptor 2A |
Disease | N/A for non-human GPCRs |
Length | 470 |
Amino acid sequence | MDILCEENTSLSSTTNSLMQLHADTRLYSTDFNSGEGNTSNAFNWTVDSENRTNLSCEGCLSPPCFSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSTLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADENFVLIGSFVAFFIPLTIMVITYFLTIKSLQKEATLCVSDPGTRTKLASFSFLPQSSLSSEKLFQRSIHREPGSYGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNRDVIEALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGPKKNSKKDDKTTDNDCTMVALGKEHPEDAPADSSNTVNEKVSCV |
UniProt | Q75Z89 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL3446 |
IUPHAR | N/A |
DrugBank | N/A |
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GLASS ID | Molecule | Formula | Molecular weight | H-bond acceptor / donor | XlogP | Lipinski's druglikeness |
---|---|---|---|---|---|---|
490 | CHEMBL54125 | C22H21FN4 | 360.436 | 4 / 0 | 4.7 | Yes |
1865 | CHEMBL53662 | C23H23FN4O | 390.462 | 5 / 0 | 4.7 | Yes |
4222 | CHEMBL25984 | C15H23NO | 233.355 | 2 / 0 | 3.8 | Yes |
4971 | CHEMBL50188 | C25H36N2O4 | 428.573 | 5 / 0 | 4.2 | Yes |
5542 | CHEMBL50722 | C25H36N2O5 | 444.572 | 6 / 0 | 4.3 | Yes |
5919 | CHEMBL50722 | C27H38N2O9 | 534.606 | 10 / 2 | N/A | No |
7262 | CHEMBL54914 | C15H17N5 | 267.336 | 4 / 0 | 2.4 | Yes |
7854 | CHEMBL63114 | C14H15N3S | 257.355 | 3 / 0 | 4.2 | Yes |
9614 | CHEMBL418678 | C20H19FN4S | 366.458 | 5 / 0 | 4.7 | Yes |
10273 | CHEMBL298649 | C22H22FN5 | 375.451 | 5 / 0 | 4.3 | Yes |
11732 | propranolol | C16H21NO2 | 259.349 | 3 / 2 | 3.0 | Yes |
11812 | CHEMBL54266 | C23H32N2O4S | 432.579 | 6 / 1 | 4.3 | Yes |
12302 | CHEMBL52800 | C22H22FN5O | 391.45 | 6 / 0 | 4.3 | Yes |
13665 | 8-OH-Dpat | C16H25NO | 247.382 | 2 / 1 | 4.1 | Yes |
18210 | CHEMBL49932 | C22H21N5O2 | 387.443 | 6 / 0 | 3.7 | Yes |
19995 | CHEMBL53490 | C14H15N5 | 253.309 | 4 / 1 | 1.9 | Yes |
23243 | DIHYDREXIDINE | C17H17NO2 | 267.328 | 3 / 3 | 2.5 | Yes |
23287 | CHEMBL303986 | C19H23N5OS | 369.487 | 5 / 0 | 3.2 | Yes |
25956 | CHEMBL62612 | C22H24N4S | 376.522 | 4 / 0 | 5.4 | No |
26647 | CHEBI:48565 | C21H26N2O3 | 354.45 | 4 / 2 | 2.9 | Yes |
33238 | CHEMBL410531 | C22H20ClFN4 | 394.878 | 4 / 0 | 5.3 | No |
41314 | CHEMBL60318 | C20H22FN3OS | 371.474 | 5 / 0 | 3.9 | Yes |
42411 | CHEMBL62911 | C21H23N4S+ | 363.503 | 3 / 0 | 4.6 | Yes |
44085 | CHEMBL50456 | C21H19Cl2N5 | 412.318 | 4 / 0 | 5.1 | No |
45204 | CHEMBL302225 | C14H16N4S | 272.37 | 4 / 0 | 3.1 | Yes |
53951 | CHEMBL65736 | C17H20N4S | 312.435 | 4 / 0 | 3.9 | Yes |
54611 | CHEMBL48925 | C25H34N2O4 | 426.557 | 5 / 1 | 4.6 | Yes |
56699 | cisapride | C23H29ClFN3O4 | 465.95 | 7 / 2 | 3.4 | Yes |
57407 | CHEMBL298534 | C24H31FN2O3 | 414.521 | 5 / 1 | 4.7 | Yes |
57913 | CHEMBL53195 | C32H35N7 | 517.681 | 6 / 0 | 5.6 | No |
58999 | CHEMBL66307 | C26H23ClN4S | 459.008 | 4 / 0 | 7.0 | No |
59260 | CHEMBL64167 | C20H23N3OS | 353.484 | 4 / 0 | 3.8 | Yes |
59695 | CHEMBL62366 | C20H20N4S | 348.468 | 4 / 0 | 4.8 | Yes |
62227 | spiperone | C23H26FN3O2 | 395.478 | 5 / 1 | 3.0 | Yes |
62315 | CHEMBL51888 | C22H30N2O4S | 418.552 | 6 / 1 | 3.9 | Yes |
62511 | CHEMBL52438 | C19H25NO | 283.415 | 2 / 0 | 5.1 | No |
63076 | CHEMBL11592 | C26H38N2O4 | 442.6 | 5 / 0 | 4.6 | Yes |
63269 | CHEMBL63289 | C16H18N4O2S | 330.406 | 5 / 0 | 3.4 | Yes |
67037 | CHEMBL65669 | C20H20N4S | 348.468 | 4 / 0 | 4.8 | Yes |
68944 | CHEMBL301060 | C28H40N2O8 | 532.634 | 9 / 2 | N/A | No |
71630 | CHEMBL261977 | C22H22N4S | 374.506 | 4 / 0 | 5.3 | No |
71961 | CHEMBL62445 | C19H18N4S | 334.441 | 4 / 1 | 4.3 | Yes |
72742 | CHEMBL59741 | C20H20F3N3OS | 407.455 | 7 / 1 | 4.5 | Yes |
78198 | domperidone | C22H24ClN5O2 | 425.917 | 3 / 2 | 3.9 | Yes |
82337 | CHEMBL52612 | C20H22N4 | 318.424 | 3 / 0 | 3.0 | Yes |
83890 | Ketanserin | C22H22FN3O3 | 395.434 | 5 / 1 | 2.6 | Yes |
84686 | CHEMBL63713 | C22H21F3N4S | 430.493 | 7 / 0 | 6.0 | No |
88081 | CHEMBL296395 | C22H24N2O4 | 380.444 | 5 / 1 | 2.9 | Yes |
88268 | CHEMBL50993 | C25H36N2O3 | 412.574 | 4 / 0 | 4.6 | Yes |
92984 | CHEMBL300735 | C24H34N2O4S | 446.606 | 6 / 1 | 4.6 | Yes |
101635 | 5-Meo-dpac | C16H25NO2 | 263.381 | 3 / 0 | 3.8 | Yes |
103231 | CHEMBL302431 | C20H18Cl2N4S | 417.352 | 4 / 0 | 5.9 | No |
112353 | CHEMBL285010 | C14H19NO2 | 233.311 | 3 / 0 | 2.5 | Yes |
113162 | CHEMBL62902 | C26H21F3N4S | 478.537 | 7 / 0 | 7.4 | No |
114701 | CHEMBL63845 | C20H17F3N4S | 402.439 | 7 / 0 | 5.8 | No |
120665 | CHEMBL54089 | C26H30N2O8 | 498.532 | 9 / 2 | N/A | N/A |
121671 | CHEMBL294730 | C22H27N3O2S | 397.537 | 5 / 0 | 4.1 | Yes |
122918 | CHEMBL52625 | C21H20FN5 | 361.424 | 5 / 0 | 4.0 | Yes |
124418 | CHEMBL104985 | C14H18ClN3O | 279.768 | 4 / 0 | 3.4 | Yes |
135890 | CHEMBL299097 | C21H21N5 | 343.434 | 4 / 0 | 4.0 | Yes |
136066 | CHEMBL59823 | C24H31N3O3 | 409.53 | 5 / 0 | 3.6 | Yes |
140732 | CHEMBL52396 | C25H30N2O4 | 422.525 | 5 / 0 | 4.3 | Yes |
142052 | CHEMBL61819 | C23H29N3O2S | 411.564 | 5 / 0 | 4.4 | Yes |
142301 | CHEMBL63790 | C21H20N4O2S | 392.477 | 6 / 0 | 4.4 | Yes |
143151 | CHEMBL545198 | C23H26N2O4 | 394.471 | 5 / 0 | 3.6 | Yes |
146217 | GR 103691 | C30H35N3O3 | 485.628 | 5 / 1 | 4.8 | Yes |
148974 | CHEMBL63905 | C19H17FN4S | 352.431 | 5 / 0 | 5.0 | Yes |
152202 | CYPROHEPTADINE | C21H21N | 287.406 | 1 / 0 | 4.7 | Yes |
152917 | CHEMBL51985 | C27H41N2O4+ | 457.635 | 4 / 0 | 4.6 | Yes |
153118 | CHEMBL545198 | C23H27ClN2O4 | 430.929 | 5 / 1 | N/A | N/A |
160443 | CHEMBL300692 | C23H23FN4 | 374.463 | 4 / 0 | 5.1 | No |
166259 | CHEMBL416662 | C23H21ClN4O2 | 420.897 | 5 / 0 | 5.1 | No |
169280 | CHEMBL54266 | C25H34N2O8S | 522.613 | 10 / 3 | N/A | No |
173359 | CHEMBL51985 | C27H41IN2O4 | 584.539 | 5 / 0 | N/A | No |
182093 | CHEMBL52485 | C24H36N2O4 | 416.562 | 5 / 0 | 3.7 | Yes |
183079 | CHEMBL293219 | C26H21F3N4S | 478.537 | 7 / 0 | 7.5 | No |
189345 | CHEMBL50841 | C24H34N2O4 | 414.546 | 5 / 0 | 3.9 | Yes |
191595 | haloperidol | C21H23ClFNO2 | 375.868 | 4 / 1 | 3.2 | Yes |
194908 | fluphenazine enanthate | C29H38F3N3O2S | 549.697 | 9 / 0 | 7.4 | No |
196477 | CHEMBL284912 | C21H34N2O3 | 362.514 | 5 / 0 | 3.3 | Yes |
198701 | CGS 12066B | C17H17F3N4 | 334.346 | 6 / 0 | 4.0 | Yes |
203489 | CUMI-101 | C19H27N5O3 | 373.457 | 6 / 0 | 1.8 | Yes |
208397 | CHEMBL416747 | C22H36N2O2 | 360.542 | 4 / 0 | 4.5 | Yes |
211956 | CHEMBL292293 | C13H13N3OS | 259.327 | 4 / 0 | 3.0 | Yes |
212747 | CHEMBL64727 | C20H18Cl2N4S | 417.352 | 4 / 0 | 5.9 | No |
213415 | CHEMBL62274 | C16H18N4S | 298.408 | 4 / 0 | 3.8 | Yes |
228334 | CHEMBL415933 | C23H28N6O | 404.518 | 5 / 0 | 3.7 | Yes |
231548 | CHEMBL51888 | C24H32N2O8S | 508.586 | 10 / 3 | N/A | No |
240592 | Phentolamine mesylate | C18H23N3O4S | 377.459 | 6 / 3 | N/A | N/A |
244518 | A-131701 | C24H24N4O3S | 448.541 | 6 / 1 | 3.2 | Yes |
250991 | CHEMBL292725 | C21H20N4O2S | 392.477 | 6 / 0 | 4.4 | Yes |
252652 | CHEMBL48925 | C27H36N2O8 | 516.591 | 9 / 3 | N/A | No |
253042 | CHEMBL65710 | C20H20N4S | 348.468 | 4 / 0 | 4.6 | Yes |
253193 | CHEMBL51225 | C20H19N5 | 329.407 | 4 / 0 | 4.2 | Yes |
253504 | CHEMBL65974 | C14H16N4S | 272.37 | 4 / 0 | 3.1 | Yes |
254622 | CHEMBL53416 | C22H22N4 | 342.446 | 3 / 0 | 4.6 | Yes |
255091 | CHEMBL298534 | C26H33FN2O7 | 504.555 | 9 / 3 | N/A | No |
257681 | CHEMBL50530 | C24H34N2O4 | 414.546 | 5 / 0 | 3.6 | Yes |
259604 | CHEMBL299561 | C26H38N2O7 | 490.597 | 8 / 2 | N/A | N/A |
266580 | CHEMBL293879 | C17H20N4O2S | 344.433 | 6 / 0 | 3.4 | Yes |
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