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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	5-hydroxytryptamine receptor 2A
Species	Bos taurus (Bovine)
Gene	HTR2A
Synonym	5-HT-2 5-HT-2A Serotonin receptor 2A
Disease	N/A for non-human GPCRs
Length	470
Amino acid sequence	MDILCEENTSLSSTTNSLMQLHADTRLYSTDFNSGEGNTSNAFNWTVDSENRTNLSCEGCLSPPCFSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSTLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADENFVLIGSFVAFFIPLTIMVITYFLTIKSLQKEATLCVSDPGTRTKLASFSFLPQSSLSSEKLFQRSIHREPGSYGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNRDVIEALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGPKKNSKKDDKTTDNDCTMVALGKEHPEDAPADSSNTVNEKVSCV
UniProt	Q75Z89
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3446
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL50841
Molecular formula	C24H34N2O4
IUPAC name	8-[2-[(5-methoxy-3,4-dihydro-2H-chromen-3-yl)-propylamino]ethyl]-8-azaspiro[4.5]decane-7,9-dione
Molecular weight	414.546
Hydrogen bond acceptor	5
Hydrogen bond donor	0
XlogP	3.9
Synonyms	8-{2-[(5-Methoxy-chroman-3-yl)-propyl-amino]-ethyl}-8-aza-spiro[4.5]decane-7,9-dione; compound with oxalic acid CHEMBL28339 BDBM50036871
Inchi Key	LJXVXMDOHJFURJ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C24H34N2O4/c1-3-11-25(18-14-19-20(29-2)7-6-8-21(19)30-17-18)12-13-26-22(27)15-24(16-23(26)28)9-4-5-10-24/h6-8,18H,3-5,9-17H2,1-2H3
PubChem CID	10047428
ChEMBL	CHEMBL28339
IUPHAR	N/A
BindingDB	50036871
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<1000000.0 nM	PMID7912735	BindingDB

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