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GPCR

Name5-hydroxytryptamine receptor 2A
SpeciesBos taurus (Bovine)
GeneHTR2A
Synonym5-HT-2
5-HT-2A
Serotonin receptor 2A
DiseaseN/A for non-human GPCRs
Length470
Amino acid sequenceMDILCEENTSLSSTTNSLMQLHADTRLYSTDFNSGEGNTSNAFNWTVDSENRTNLSCEGCLSPPCFSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSTLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADENFVLIGSFVAFFIPLTIMVITYFLTIKSLQKEATLCVSDPGTRTKLASFSFLPQSSLSSEKLFQRSIHREPGSYGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNRDVIEALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGPKKNSKKDDKTTDNDCTMVALGKEHPEDAPADSSNTVNEKVSCV
UniProtQ75Z89
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3446
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL51985
Molecular formulaC27H41IN2O4
IUPAC name4-(7,9-dioxo-8-azaspiro[4.5]decan-8-yl)butyl-(5-methoxy-3,4-dihydro-2H-chromen-3-yl)-methyl-propylazanium;iodide
Molecular weight584.539
Hydrogen bond acceptor5
Hydrogen bond donor0
XlogPNone
SynonymsN/A
Inchi KeyKNHLNXSTGUWQNP-UHFFFAOYSA-M
Inchi IDInChI=1S/C27H41N2O4.HI/c1-4-15-29(2,21-17-22-23(32-3)10-9-11-24(22)33-20-21)16-8-7-14-28-25(30)18-27(19-26(28)31)12-5-6-13-27;/h9-11,21H,4-8,12-20H2,1-3H3;1H/q+1;/p-1
PubChem CID10008462
ChEMBLCHEMBL51985
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
Partition coefficient log P of this ligand is not available.

Experimental Data

ParameterValueReferenceDatabase source
IC50<1000000.0 nMPMID7912735ChEMBL

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