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| Name | 5-hydroxytryptamine receptor 1B |
|---|---|
| Species | Homo sapiens (Human) |
| Gene | HTR1B |
| Synonym | 5-HT1B receptor 5-HT-1B 5-HT-1D-beta 5-HT1B Serotonin 1D beta receptor [ Show all ] |
| Disease | Chronic schizophrenics Major depressive disorder Migraine headaches Mood disorder Psychotic disorders [ Show all ] |
| Length | 390 |
| Amino acid sequence | MEEPGAQCAPPPPAGSETWVPQANLSSAPSQNCSAKDYIYQDSISLPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLPPFFWRQAKAEEEVSECVVNTDHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRILKQTPNRTGKRLTRAQLITDSPGSTSSVTSINSRVPDVPSESGSPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKCTS |
| UniProt | P28222 |
| Protein Data Bank | 4iar, 6g79, 5v54 |
| GPCR-HGmod model | P28222 |
| 3D structure model | This structure is from PDB ID 4iar. |
| BioLiP | BL0239857, BL0403524,BL0403525, BL0417722 |
| Therapeutic Target Database | T07806 |
| ChEMBL | CHEMBL1898 |
| IUPHAR | 2 |
| DrugBank | BE0000797 |
You can:
| GLASS ID | Molecule | Formula | Molecular weight | H-bond acceptor / donor | XlogP | Lipinski's druglikeness |
|---|---|---|---|---|---|---|
| 173 |  CHEMBL2111779 | C24H25N3O2 | 387.483 | 4 / 1 | 3.8 | Yes |
| 177 |  CHEMBL119800 | C24H25N3O2 | 387.483 | 4 / 1 | 3.8 | Yes |
| 622 |  CHEMBL306197 | C25H32N2O | 376.544 | 2 / 1 | 6.0 | No |
| 1008 |  CHEMBL2205816 | C18H20N2O | 280.371 | 3 / 1 | 1.8 | Yes |
| 553251 |  7-Hydroxy Risperidone | C23H27FN4O3 | 426.492 | 7 / 1 | 1.7 | Yes |
| 1328 |  CHEMBL109839 | C21H34N2O | 330.516 | 2 / 2 | 5.6 | No |
| 1381 |  CHEMBL352181 | C26H30N4S | 430.614 | 3 / 2 | 4.8 | Yes |
| 1696 |  CHEMBL470849 | C25H28N4O2 | 416.525 | 5 / 1 | 3.8 | Yes |
| 2159 |  CHEMBL81703 | C25H25FN2O2S | 436.545 | 5 / 1 | 3.9 | Yes |
| 2188 |  CHEMBL458002 | C29H28ClN5O2 | 514.026 | 5 / 2 | 4.3 | No |
| 2265 |  1-(cyclohexylmethyl)pyrrolidine | C11H21N | 167.296 | 1 / 0 | 3.1 | Yes |
| 3149 |  AC1N0YGA | C3H7NO4S | 153.152 | 5 / 2 | -4.7 | Yes |
| 3331 |  CHEMBL196961 | C29H33N5O2S | 515.676 | 7 / 0 | 4.0 | No |
| 3402 |  CHEMBL1642882 | C18H19ClN4O2S | 390.886 | 5 / 3 | 3.4 | Yes |
| 3986 |  CHEMBL109360 | C17H24N2O2 | 288.391 | 3 / 1 | 2.7 | Yes |
| 4037 |  CHEMBL225308 | C26H33N5O4 | 479.581 | 8 / 2 | 2.5 | Yes |
| 4095 |  CHEMBL1173578 | C21H16ClN5O2S2 | 469.962 | 7 / 0 | 4.6 | Yes |
| 4308 |  Butanedioic acid, compd. with 5-methoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole (1:1) | C18H22N2O5 | 346.383 | 6 / 4 | N/A | N/A |
| 4561 |  CHEMBL495161 | C25H30N4O2 | 418.541 | 5 / 1 | 3.1 | Yes |
| 5063 |  BDBM50068818 | C32H39N5O6 | 589.693 | 8 / 2 | 2.9 | No |
| 5255 |  SB-258719 | C18H30N2O2S | 338.51 | 4 / 0 | 3.5 | Yes |
| 5673 |  AC1L1HUK | C29H28ClN3O4 | 518.01 | 4 / 2 | 5.2 | No |
| 6142 |  CHEMBL144128 | C28H38N6O2 | 490.652 | 6 / 4 | 2.3 | Yes |
| 6275 |  CHEMBL76237 | C19H22N2O3S | 358.456 | 4 / 0 | 3.5 | Yes |
| 463740 |  CHEMBL3633757 | C26H24BrNO4 | 494.385 | 5 / 0 | 5.4 | No |
| 536132 |  CHEMBL3899832 | C22H19N5O4 | 417.425 | 8 / 2 | 3.6 | Yes |
| 7827 |  CHEMBL469668 | C20H29F3N2O2 | 386.459 | 7 / 1 | 3.9 | Yes |
| 8120 |  CHEMBL317333 | C26H24FN5 | 425.511 | 5 / 0 | 4.0 | Yes |
| 8206 |  BW-723C86 | C16H18N2OS | 286.393 | 3 / 2 | 3.0 | Yes |
| 8250 |  CHEMBL2260924 | C15H20Br2N2O5 | 468.142 | 7 / 2 | N/A | N/A |
| 521694 |  CHEMBL3754496 | C16H19FN2 | 258.34 | 2 / 1 | 2.9 | Yes |
| 8803 |  CHEMBL198488 | C31H33N7O | 519.653 | 6 / 0 | 4.7 | No |
| 9004 |  naratriptan | C17H25N3O2S | 335.466 | 4 / 2 | 2.0 | Yes |
| 9387 |  CHEMBL356315 | C27H34N6O | 458.61 | 5 / 3 | 3.3 | Yes |
| 9389 |  CHEMBL143947 | C27H34N6O | 458.61 | 5 / 3 | 3.3 | Yes |
| 9543 |  GSK163090 | C25H29N5O | 415.541 | 4 / 1 | 3.4 | Yes |
| 9699 |  CHEMBL309162 | C12H16N2O | 204.273 | 2 / 2 | 1.2 | Yes |
| 9880 |  AC-42 | C20H31NO | 301.474 | 2 / 0 | 5.2 | No |
| 10183 |  CHEMBL194206 | C23H30FN5O2 | 427.524 | 6 / 1 | 2.7 | Yes |
| 10262 |  CHEMBL164111 | C22H26N6O | 390.491 | 5 / 1 | 2.2 | Yes |
| 10700 |  CHEMBL114303 | C28H36N6O | 472.637 | 5 / 2 | 3.5 | Yes |
| 10733 |  CHEMBL3287723 | C25H32O7 | 444.524 | 7 / 2 | 5.7 | No |
| 10971 |  CHEMBL143952 | C25H30N6O2S | 478.615 | 6 / 2 | 3.3 | Yes |
| 11012 |  CHEMBL458200 | C29H36N4O2 | 472.633 | 5 / 0 | 4.7 | Yes |
| 11056 |  tryptamine | C10H12N2 | 160.22 | 1 / 2 | 1.6 | Yes |
| 11233 |  CHEMBL1241912 | C28H30N6O2 | 482.588 | 6 / 1 | 3.4 | Yes |
| 11699 |  Propranolol, L- | C16H21NO2 | 259.349 | 3 / 2 | 3.0 | Yes |
| 11738 |  propranolol | C16H21NO2 | 259.349 | 3 / 2 | 3.0 | Yes |
| 12525 |  CHEMBL333341 | C27H34N6 | 442.611 | 4 / 1 | 4.1 | Yes |
| 12607 |  CHEMBL162012 | C27H32N4O | 428.58 | 3 / 2 | 4.6 | Yes |
| 13028 |  CHEMBL79725 | C24H26FN3O2 | 407.489 | 4 / 2 | 3.0 | Yes |
| 13657 |  8-OH-Dpat | C16H25NO | 247.382 | 2 / 1 | 4.1 | Yes |
| 13793 |  CHEMBL199443 | C25H28N6OS | 460.6 | 7 / 0 | 2.7 | Yes |
| 13828 |  CHEMBL82890 | C27H34N6O3 | 490.608 | 5 / 4 | 3.1 | Yes |
| 13983 |  CHEMBL1289163 | C26H27FN4O | 430.527 | 5 / 0 | 4.2 | Yes |
| 14226 |  180083-23-2 | C32H32N4O3 | 520.633 | 6 / 0 | 5.6 | No |
| 15476 |  CHEMBL2205829 | C19H19NO3 | 309.365 | 4 / 1 | 2.2 | Yes |
| 15599 |  CHEMBL246598 | C28H33N3O3 | 459.59 | 5 / 0 | 4.8 | Yes |
| 16630 |  CHEMBL351036 | C26H29ClN4S | 465.056 | 3 / 2 | 5.4 | No |
| 16683 |  CHEMBL282229 | C30H32N4O4 | 512.61 | 7 / 0 | 5.2 | No |
| 16775 |  Pipamperone | C21H30FN3O2 | 375.488 | 5 / 1 | 2.0 | Yes |
| 17274 |  CHEMBL147546 | C29H37N7O | 499.663 | 5 / 2 | 3.6 | Yes |
| 17429 |  CHEMBL83617 | C25H26FN3O2 | 419.5 | 4 / 2 | 3.0 | Yes |
| 18509 |  SCHEMBL2881638 | C27H34N4O | 430.596 | 4 / 1 | 5.1 | No |
| 18649 |  CHEMBL345657 | C23H27N7 | 401.518 | 5 / 2 | 1.9 | Yes |
| 19071 |  CHEMBL282693 | C28H31N5O3 | 485.588 | 7 / 2 | 5.0 | Yes |
| 19114 |  CHEMBL162771 | C26H36N4O | 420.601 | 3 / 2 | 4.6 | Yes |
| 19552 |  CHEMBL106807 | C24H31ClN4O2 | 442.988 | 5 / 0 | 3.9 | Yes |
| 20092 |  CHEMBL1631541 | C26H31N5O | 429.568 | 4 / 1 | 3.8 | Yes |
| 20210 |  CHEMBL297660 | C17H24N2 | 256.393 | 1 / 1 | 3.6 | Yes |
| 20323 |  CHEMBL423212 | C24H30N6S | 434.606 | 5 / 1 | 3.7 | Yes |
| 20739 |  CHEMBL350153 | C28H36N4O2 | 460.622 | 4 / 1 | 4.3 | Yes |
| 20813 |  CHEMBL509314 | C51H60F2N6O2 | 827.078 | 6 / 4 | 11.0 | No |
| 21148 |  SCHEMBL3825498 | C23H32N2O2S | 400.581 | 4 / 0 | 4.9 | Yes |
| 21158 |  CHEMBL114012 | C23H32N2O2S | 400.581 | 4 / 0 | 4.9 | Yes |
| 21787 |  CHEMBL357034 | C15H22N2 | 230.355 | 1 / 2 | 3.2 | Yes |
| 22022 |  CHEMBL239596 | C25H29ClN4O2 | 452.983 | 6 / 0 | 4.8 | Yes |
| 22553 |  CHEMBL283036 | C19H19F3N4 | 360.384 | 6 / 1 | 3.6 | Yes |
| 23382 |  CHEMBL309872 | C25H26ClN3O2 | 435.952 | 3 / 2 | 3.5 | Yes |
| 23566 |  CHEMBL450852 | C44H44F2N6O2 | 726.873 | 6 / 4 | 7.2 | No |
| 23800 |  CHEMBL191619 | C23H25Cl2N3O | 430.373 | 4 / 0 | 5.2 | No |
| 24289 |  CHEMBL2181168 | C21H24IN3O | 461.347 | 4 / 0 | 5.1 | No |
| 24536 |  CHEMBL511279 | C26H28F2N4O2 | 466.533 | 7 / 0 | 4.5 | Yes |
| 24810 |  lysergol | C16H18N2O | 254.333 | 2 / 2 | 2.2 | Yes |
| 24813 |  Lysergole | C16H18N2O | 254.333 | 2 / 2 | 2.2 | Yes |
| 536621 |  2-Chloroadenosine | C10H12ClN5O4 | 301.687 | 8 / 4 | -0.1 | Yes |
| 25132 |  CHEMBL329280 | C28H31FN6O | 486.595 | 4 / 1 | 3.4 | Yes |
| 26022 |  LISURIDE | C20H26N4O | 338.455 | 2 / 2 | 2.7 | Yes |
| 26056 |  S-(-)-Lisuride | C20H26N4O | 338.455 | 2 / 2 | 2.7 | Yes |
| 26084 |  AC1L1H1T | C20H26N4O | 338.455 | 2 / 2 | 2.7 | Yes |
| 26289 |  CHEMBL600053 | C18H18FNO | 283.346 | 3 / 1 | 2.5 | Yes |
| 553395 |  Rauwolscine | C21H26N2O3 | 354.45 | 4 / 2 | 2.9 | Yes |
| 26579 |  Yohimbine | C21H26N2O3 | 354.45 | 4 / 2 | 2.9 | Yes |
| 26630 |  CHEBI:48565 | C21H26N2O3 | 354.45 | 4 / 2 | 2.9 | Yes |
| 26802 |  CHEMBL69562 | C19H28N2 | 284.447 | 1 / 1 | 5.0 | Yes |
| 27032 |  CHEMBL116153 | C25H28F2N6 | 450.538 | 6 / 1 | 3.8 | Yes |
| 27050 |  SB-357134 | C17H18Br2FN3O3S | 523.215 | 7 / 2 | 3.4 | No |
| 27086 |  CHEMBL445651 | C20H20FN3O2 | 353.397 | 5 / 1 | 3.3 | Yes |
| 27172 |  CHEMBL2203713 | C18H22N4S | 326.462 | 4 / 2 | 2.9 | Yes |
| 27330 |  CHEMBL372651 | C28H27N7O | 477.572 | 6 / 1 | 3.5 | Yes |
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