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Name | 5-hydroxytryptamine receptor 7 |
---|---|
Species | Cavia porcellus (Guinea pig) |
Gene | HTR7 |
Synonym | 5-HT-7 5-HT-X 5-HT7 Serotonin receptor 7 |
Disease | N/A for non-human GPCRs |
Length | 446 |
Amino acid sequence | MMGVNSSGRPDLYGHLHSILLPGRGLPDWSPDGGADPGVSTWTPRLLSGVPEVAASPSPSWDGTWDNVSGCGEQINYGRAEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVIPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMPKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYRIYKAARKSAAKHKFPGFPRVQPESIISLNGMVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTACSCIPLWVERTCLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERPECVLQNSDYCRKKGHDS |
UniProt | P50407 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL5494 |
IUPHAR | N/A |
DrugBank | N/A |
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GLASS ID | Molecule | Formula | Molecular weight | H-bond acceptor / donor | XlogP | Lipinski's druglikeness |
---|---|---|---|---|---|---|
11064 | tryptamine | C10H12N2 | 160.22 | 1 / 2 | 1.6 | Yes |
555532 | N-Methylserotonin | C11H14N2O | 190.246 | 2 / 3 | 0.7 | Yes |
13666 | 8-OH-Dpat | C16H25NO | 247.382 | 2 / 1 | 4.1 | Yes |
17680 | CHEMBL243955 | C28H40N4O | 448.655 | 4 / 1 | 4.6 | Yes |
555582 | S-(-)-Lisuride | C20H26N4O | 338.455 | 2 / 2 | 2.7 | Yes |
26089 | AC1L1H1T | C20H26N4O | 338.455 | 2 / 2 | 2.7 | Yes |
30216 | LP-211 | C30H34N4O | 466.629 | 4 / 1 | 5.0 | Yes |
47774 | CHEMBL243744 | C29H41N3O | 447.667 | 3 / 1 | 5.6 | No |
62193 | spiperone | C23H26FN3O2 | 395.478 | 5 / 1 | 3.0 | Yes |
66044 | Dipropyl-5-CT | C17H25N3O | 287.407 | 2 / 2 | 2.2 | Yes |
83886 | Ketanserin | C22H22FN3O3 | 395.434 | 5 / 1 | 2.6 | Yes |
125652 | SB-269970 | C18H28N2O3S | 352.493 | 5 / 1 | 2.9 | Yes |
126067 | Pirenperone | C23H24FN3O2 | 393.462 | 5 / 0 | 2.6 | Yes |
555991 | RS-102221 | C27H31F3N4O7S | 612.621 | 12 / 3 | 2.7 | No |
152192 | CYPROHEPTADINE | C21H21N | 287.406 | 1 / 0 | 4.7 | Yes |
154018 | BDBM86527 | C18H26N4O2S | 362.492 | 5 / 1 | 1.4 | Yes |
556054 | Mesulergine | C18H26N4O2S | 362.492 | 5 / 1 | 1.4 | Yes |
155641 | trans -Dihydrolisuride | C20H28N4O | 340.471 | 2 / 2 | 2.5 | Yes |
556066 | terguride | C20H28N4O | 340.471 | 2 / 2 | 2.5 | Yes |
159345 | 5-METHOXYTRYPTAMINE | C11H14N2O | 190.246 | 2 / 2 | 0.5 | Yes |
160343 | ritanserin | C27H25F2N3OS | 477.574 | 6 / 0 | 5.2 | No |
163946 | pindolol | C14H20N2O2 | 248.326 | 3 / 3 | 1.8 | Yes |
174835 | 1-Methyllysergic acid butanolamide | C21H27N3O2 | 353.466 | 3 / 2 | 2.3 | Yes |
556166 | methysergide | C21H27N3O2 | 353.466 | 3 / 2 | 2.3 | Yes |
175642 | sumatriptan | C14H21N3O2S | 295.401 | 4 / 2 | 0.9 | Yes |
191606 | haloperidol | C21H23ClFNO2 | 375.868 | 4 / 1 | 3.2 | Yes |
193759 | CHEMBL492871 | C29H35N3O | 441.619 | 3 / 1 | 5.3 | No |
200415 | CHEMBL492480 | C31H37N3O | 467.657 | 3 / 0 | 5.5 | No |
210233 | CHEMBL244161 | C27H38N4O | 434.628 | 4 / 2 | 4.4 | Yes |
227408 | LP-12 | C32H39N3O | 481.684 | 3 / 1 | 6.1 | No |
556428 | PINDOBIND-5-HT1A | C23H34BrN3O3 | 480.447 | 4 / 3 | 3.6 | Yes |
247209 | CHEMBL222188 | C26H35N3O | 405.586 | 3 / 1 | 4.5 | Yes |
251644 | CHEMBL222477 | C26H34ClN3O | 440.028 | 3 / 1 | 5.1 | No |
272903 | 5-Carboxamidotryptamine maleate | C15H17N3O5 | 319.317 | 6 / 5 | N/A | N/A |
288430 | amoxapine | C17H16ClN3O | 313.785 | 3 / 1 | 2.6 | Yes |
290299 | serotonin | C10H12N2O | 176.219 | 2 / 3 | 0.2 | Yes |
291483 | risperidone | C23H27FN4O2 | 410.493 | 6 / 0 | 2.7 | Yes |
297362 | CHEMBL494709 | C28H34N4O | 442.607 | 4 / 1 | 4.2 | Yes |
299032 | methiothepin | C20H24N2S2 | 356.546 | 4 / 0 | 4.2 | Yes |
556846 | (S)-mianserin | C18H20N2 | 264.372 | 2 / 0 | 3.4 | Yes |
335029 | mianserin | C18H20N2 | 264.372 | 2 / 0 | 3.4 | Yes |
556877 | methylergonovine | C20H25N3O2 | 339.439 | 3 / 3 | 2.3 | Yes |
340744 | MLS000756415 | C20H25N3O2 | 339.439 | 3 / 3 | 2.3 | Yes |
347137 | 8 beta-[(Methylthio)methyl]-6-propylergoline | C20H30N2O3S2 | 410.591 | 5 / 2 | N/A | N/A |
556911 | Lysergide | C20H25N3O | 323.44 | 2 / 1 | 3.0 | Yes |
350552 | D-Lysergic acid N,N-diethylamide | C20H25N3O | 323.44 | 2 / 1 | 3.0 | Yes |
556972 | 6-Methoxytryptamine | C11H14N2O | 190.246 | 2 / 2 | 1.5 | Yes |
364105 | Bufotenine | C12H16N2O | 204.273 | 2 / 2 | 1.2 | Yes |
374168 | prochlorperazine | C20H24ClN3S | 373.943 | 4 / 0 | 4.9 | Yes |
375655 | 5-Benzyloxytryptamine | C17H18N2O | 266.344 | 2 / 2 | 2.0 | Yes |
375960 | 5-Carboxamidotryptamine | C11H13N3O | 203.245 | 2 / 3 | -0.6 | Yes |
385809 | 2-Methyl-5-hydroxytryptamine | C11H14N2O | 190.246 | 2 / 3 | 1.4 | Yes |
557101 | metergoline | C25H29N3O2 | 403.526 | 3 / 1 | 3.8 | Yes |
386168 | Metergoline phenylmethyl ester | C25H29N3O2 | 403.526 | 3 / 1 | 3.8 | Yes |
388231 | NSC95090 | C33H35N5O5 | 581.673 | 6 / 3 | 2.0 | No |
557109 | ERGOTAMINE | C33H35N5O5 | 581.673 | 6 / 3 | 2.0 | No |
399437 | Clorotepine | C19H21ClN2S | 344.901 | 3 / 0 | 4.3 | Yes |
557182 | pergolide | C19H26N2S | 314.491 | 2 / 1 | 4.2 | Yes |
424643 | CHEMBL225571 | C26H34N4O3 | 450.583 | 5 / 1 | 4.3 | Yes |
426743 | trifluoperazine | C21H24F3N3S | 407.499 | 7 / 0 | 5.0 | Yes |
557282 | 5-Methoxy-N,N-dimethyltryptamine | C13H18N2O | 218.3 | 2 / 1 | 1.5 | Yes |
557302 | (+)-Butaclamol | C25H31NO | 361.529 | 2 / 1 | 5.0 | Yes |
441241 | BUTACLAMOL | C25H31NO | 361.529 | 2 / 1 | 5.0 | Yes |
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