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Check the ligand table for details.
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Go to the individual GPCR page for PubMed ID information by text mining.
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Ligand

Name	amoxapine
Molecular formula	C17H16ClN3O
IUPAC name	8-chloro-6-piperazin-1-ylbenzo[b][1,4]benzoxazepine
Molecular weight	313.785
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	2.6
Synonyms	Amoxapine [USAN:BAN:INN:JAN] KBioSS_000926 amoxipine MCULE-9583761109 BDBM22870 NCGC00015004-02 C-54133 NCGC00015004-10 CL 67772 (E)-2-chloro-11-(piperazin-1-yl)dibenzo[b,f][1,4]oxazepine 2-Chloro-11-(1-piperazinyl)- dibenz[b,f][1,4]oxazepine DIBENZ(b,f)(1,4)OXAZEPINE, 2-CHLORO-11-(1-PIPERAZINYL)- 2-chloro-11-piperazin-1-yldibenzo[b,f][1,4]oxazepine EINECS 237-867-1 A-129 HMS2231E13 AKOS015895092 IDI1_000236 Tox21_500116 NCGC00023887-06 PDSP1_001609 QWGDMFLQWFTERH-UHFFFAOYSA-N SMR000058416 Spectrum_000446 KBio2_000926 Amoxapine, Pharmaceutical Secondary Standard; Certified Reference Material L001293 Asendin MolPort-003-666-768 BRD-K02265150-001-05-9 NCGC00015004-05 CCG-39135 CPD000058416 13-chloro-10-(piperazin-1-yl)-2-oxa-9-azatricyclo[9.4.0.0;{3,8}]pentadeca-1(11),3(8),4,6,9,12,14-heptaene Defanyl (TN) 2-Chloro-11-(1-piperazinyl)dibenzo[b,f][1,4]oxazepine DivK1c_000236 8-chloranyl-6-piperazin-1-yl-benzo[b][1,4]benzoxazepine GTPL201 AB00052421_14 HMS3370P03 Amoxapina SR-01000003001-4 Z1551429736 NINDS_000236 Prestwick0_000102 s4218 SPECTRUM2300161 KBio3_001874 Amoxapinum [INN-Latin] LP00116 Asendis (TN) NC00546 BSPBio_000084 NCGC00015004-08 CHEMBL1113 D00228 14028-44-5 Desmethylloxapin 2-Chloro-11-(1-piperazinyl)dibenz[b,f][1,4]oxazepine DSSTox_RID_76652 8-chloro-6-piperazin-1-ylbenzo[b][1,4]benzoxazepine HMS2093N08 AC-5495 HY-B0991 Amoxapine (JP15/USP/INN) Tox21_110064_1 NCGC00023887-04 O286 Prestwick3_000102 SC-79931 Spectrum4_001218 Amoxapine [USAN:USP:INN:BAN:JAN] KS-000014ZS AN-10914 MFCD00069210 BG0035 NCGC00015004-03 C17H16ClN3O NCGC00015004-11 CL-67,772 DB00543 2-Chloro-11-(1-piperazinyl)-dibenz[b,f][1,4]oxazepine Dibenzo[b,f][1,4]oxazepine, 2-chloro-11-(1-piperazinyl)- EU-0100116 A807639 HMS3259G08 Amoxan J-007373 UNII-R63VQ857OT NCGC00255124-01 PDSP2_001593 R63VQ857OT SPBio_001150 SR-01000003001 KBio2_003494 Amoxapine, United States Pharmacopeia (USP) Reference Standard Lopac-A-129 Asendin (TN) Moxadil BRD-K02265150-001-15-8 NCGC00015004-06 CHEBI:2675 CS-4485 13-chloro-10-(piperazin-1-yl)-2-oxa-9-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,9,12,14-heptaene Demolox 2-Chloro-11-(1-piperazinyl)dibenzo[b,f][1,4]oxazepine # DSSTox_CID_2598 8-chloro-6-(1-piperazinyl)benzo[b][1,4]benzoxazepine HMS1568E06 AB00052421_15 HMS3712E06 Amoxapina [INN-Spanish] SR-01000003001-6 ZINC931 NCGC00015004-16 NSC-759559 Prestwick1_000102 SAM002564189 Spectrum2_001245 Amoxapine (JP17/USP/INN) KBioGR_001656 Amoxepine LS-61563 BC657161 NCGC00015004-01 BSPBio_002654 NCGC00015004-09 CL 67,772 D09IOI 2-Chlor-11-(1-piperazinyl)dibenz(b,f)(1,4)oxazepin Desmethylloxapine 2-chloro-11-(piperazin-1-yl)dibenzo[b,f][1,4]oxazepine DTXSID7022598 8-chloro-6-piperazin-1-ylbenzo[b][1,5]benzoxazepine HMS2095E06 AC1L1D2U I06-0520 Tox21_302352 NCGC00023887-05 Opera_ID_33 Prestwick_503 SCHEMBL33950 Spectrum5_001284 Amoxapine, 1.0 mg/mL in methanol, certified reference material KS-1197 Ascendin MLS000069371 BPBio1_000094 NCGC00015004-04 CAS-14028-44-5 NCGC00015004-13 CL-67772 028A445 Defanyl 2-Chloro-11-(1-piperazinyl)dibenz(b,f)(1,4)oxazepine Dibenz[b,f][1,4]oxazepine, 2-chloro-11-(1-piperazinyl)- FT-0659871 AB00052421-13 HMS3260G14 Amoxapin KBio1_000236 VA10272 NCGC00260801-01 Pharmakon1600-02300161 REGID_for_CID_2170 SPBio_002023 SR-01000003001-2 KBio2_006062 Amoxapinum Lopac0_000116 Asendis Moxadil (TN) BRN 0832057 NCGC00015004-07 CTK8F7751 13-chloro-10-(piperazin-1-yl)-2-oxa-9-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3,5,7,9,12,14-heptaene Demolox (TN) 2-Chloro-11-(1-piperazinyl)dibenz[b,f]-1,4-oxazepine DSSTox_GSID_22598 8-chloro-6-piperazin-1-yl-benzo[b][1,4]benzoxazepine HMS2089G10 ABP000992 HMS500L18 Tox21_110064 NCGC00023887-03 NSC759559 Prestwick2_000102 SBI-0050104.P003 Spectrum3_001067 [ Show all ]
Inchi Key	QWGDMFLQWFTERH-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H16ClN3O/c18-12-5-6-15-13(11-12)17(21-9-7-19-8-10-21)20-14-3-1-2-4-16(14)22-15/h1-6,11,19H,7-10H2
PubChem CID	2170
ChEMBL	CHEMBL1113
IUPHAR	201
BindingDB	22870
DrugBank	DB00543
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
288405	5-hydroxytryptamine receptor 1A	P08908	HTR1A	Homo sapiens (Human)	422
288433	5-hydroxytryptamine receptor 1B	P28222	HTR1B	Homo sapiens (Human)	390
288417	5-hydroxytryptamine receptor 2A	P28223	HTR2A	Homo sapiens (Human)	471
554709	5-hydroxytryptamine receptor 2A	P14842	Htr2a	Rattus norvegicus (Rat)	471
288423	5-hydroxytryptamine receptor 2B	P41595	HTR2B	Homo sapiens (Human)	481
288408	5-hydroxytryptamine receptor 2C	P28335	HTR2C	Homo sapiens (Human)	458
288419	5-hydroxytryptamine receptor 2C	P08909	Htr2c	Rattus norvegicus (Rat)	460
288418	5-hydroxytryptamine receptor 6	P50406	HTR6	Homo sapiens (Human)	440
288432	5-hydroxytryptamine receptor 6	P31388	Htr6	Rattus norvegicus (Rat)	436
288428	5-hydroxytryptamine receptor 7	P34969	HTR7	Homo sapiens (Human)	479
288430	5-hydroxytryptamine receptor 7	P50407	HTR7	Cavia porcellus (Guinea pig)	446
554708	5-hydroxytryptamine receptor 7	P32305	Htr7	Rattus norvegicus (Rat)	448
288435	Alpha-1A adrenergic receptor	P35348	ADRA1A	Homo sapiens (Human)	466
453079	Alpha-1A adrenergic receptor	P43140	Adra1a	Rattus norvegicus (Rat)	466
288409	Alpha-1B adrenergic receptor	P15823	Adra1b	Rattus norvegicus (Rat)	515
288421	Alpha-1D adrenergic receptor	P25100	ADRA1D	Homo sapiens (Human)	572
288427	Alpha-2A adrenergic receptor	P08913	ADRA2A	Homo sapiens (Human)	450
288411	Alpha-2B adrenergic receptor	P18089	ADRA2B	Homo sapiens (Human)	450
288406	Alpha-2C adrenergic receptor	P18825	ADRA2C	Homo sapiens (Human)	462
288404	D(1A) dopamine receptor	P21728	DRD1	Homo sapiens (Human)	446

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