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| Name | Alpha-1A adrenergic receptor |
|---|---|
| Species | Rattus norvegicus (Rat) |
| Gene | Adra1a |
| Synonym | alpha1c alpha1A-adrenoceptor alpha1a Alpha-1C adrenergic receptor Alpha-1A adrenoreceptor [ Show all ] |
| Disease | N/A for non-human GPCRs |
| Length | 466 |
| Amino acid sequence | MVLLSENASEGSNCTHPPAPVNISKAILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWVLSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYVPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNVPAEGGGVSSAKNKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLRRRQSSKHALGYTLHPPSQALEGQHRDMVRIPVGSGETFYKISKTDGVCEWKFFSSMPQGSARITVPKDQSACTTARVRSKSFLQVCCCVGSSAPRPEENHQVPTIKIHTISLGENGEEV |
| UniProt | P43140 |
| Protein Data Bank | N/A |
| GPCR-HGmod model | N/A |
| 3D structure model | No available structures or models |
| BioLiP | N/A |
| Therapeutic Target Database | N/A |
| ChEMBL | CHEMBL319 |
| IUPHAR | 22 |
| DrugBank | N/A |
You can:
| GLASS ID | Molecule | Formula | Molecular weight | H-bond acceptor / donor | XlogP | Lipinski's druglikeness |
|---|---|---|---|---|---|---|
| 90 |  Eticlopride | C17H25ClN2O3 | 340.848 | 4 / 2 | 3.1 | Yes |
| 261 |  CHEMBL122047 | C25H30ClFN4O2 | 472.989 | 4 / 0 | 4.5 | Yes |
| 276 |  2-{3-[4-(2-methoxyphenyl)-1-piperazinyl]propyl}tetrahydro-1H-pyrrolo[1,2-c]imidazole-1,3(2H)-dione | C20H28N4O3 | 372.469 | 5 / 0 | 1.8 | Yes |
| 1128 |  CHEMBL287965 | C24H24N4O3S | 448.541 | 6 / 1 | 3.1 | Yes |
| 2045 |  CHEMBL252818 | C24H28N4OS | 420.575 | 5 / 1 | 4.1 | Yes |
| 3040 |  CHEMBL1255085 | C23H25NO5 | 395.455 | 6 / 3 | 3.9 | Yes |
| 555486 |  Strychnine, Nb-oxide | C21H22N2O3 | 350.418 | 3 / 0 | 1.4 | Yes |
| 555493 |  (1S,2R)-2-phenylcyclopropanamine | C9H11N | 133.194 | 1 / 1 | 1.5 | Yes |
| 555494 |  tranylcypromine | C9H11N | 133.194 | 1 / 1 | 1.5 | Yes |
| 441854 |  CHEMBL3342860 | C27H32F3N3O4 | 519.565 | 9 / 0 | 3.9 | No |
| 4503 |  CHEMBL215151 | C24H26ClNO4 | 427.925 | 5 / 2 | N/A | N/A |
| 4731 |  lipoic acid | C8H14O2S2 | 206.318 | 4 / 1 | 1.7 | Yes |
| 5776 |  paroxetine | C19H20FNO3 | 329.371 | 5 / 1 | 3.5 | Yes |
| 6905 |  CHEMBL25098 | C33H37N3O4 | 539.676 | 6 / 1 | 5.6 | No |
| 7581 |  p-Cumaroylagmatin | C14H20N4O2 | 276.34 | 3 / 4 | 0.4 | Yes |
| 7582 |  p-Coumaroylagmatine | C14H20N4O2 | 276.34 | 3 / 4 | 0.4 | Yes |
| 442022 |  CHEMBL3342852 | C19H28N2O3S | 364.504 | 6 / 0 | 2.5 | Yes |
| 7885 |  CHEMBL253878 | C30H32N4OS | 496.673 | 5 / 1 | 5.7 | No |
| 536196 |  CHEMBL27021 | C19H24N2O | 296.414 | 3 / 0 | 3.8 | Yes |
| 8780 |  CHEMBL220515 | C24H26ClN5O2 | 451.955 | 5 / 1 | 3.6 | Yes |
| 8900 |  Ethanesulfonamide, N-[3-(3-pyrrolidinyl)phenyl]- | C12H18N2O2S | 254.348 | 4 / 2 | 1.0 | Yes |
| 9547 |  GSK163090 | C25H29N5O | 415.541 | 4 / 1 | 3.4 | Yes |
| 9925 |  CHEMBL343188 | C18H18N8O5 | 426.393 | 11 / 1 | 1.1 | No |
| 10625 |  CHEMBL145712 | C28H35FN4O | 462.613 | 3 / 0 | 4.7 | Yes |
| 10776 |  CHEMBL1242445 | C26H33N3O4 | 451.567 | 6 / 0 | 2.4 | Yes |
| 10784 |  CHEMBL1242444 | C26H33N3O4 | 451.567 | 6 / 0 | 2.4 | Yes |
| 442132 |  CHEMBL3415012 | C24H30N4O2 | 406.53 | 4 / 2 | 3.2 | Yes |
| 11100 |  CHEMBL2261352 | C14H18N4O2 | 274.324 | 3 / 4 | 0.0 | Yes |
| 11275 |  CHEMBL1946783 | C31H34N2O6 | 530.621 | 8 / 2 | N/A | No |
| 11531 |  3-MPPI | C23H25N5O3 | 419.485 | 5 / 2 | 2.7 | Yes |
| 555527 |  propranolol | C16H21NO2 | 259.349 | 3 / 2 | 3.0 | Yes |
| 12632 |  CHEMBL62033 | C24H24N4O3 | 416.481 | 5 / 1 | 2.5 | Yes |
| 13686 |  8-OH-Dpat | C16H25NO | 247.382 | 2 / 1 | 4.1 | Yes |
| 13978 |  CHEMBL57364 | C21H28ClN3O2 | 389.924 | 4 / 0 | 3.5 | Yes |
| 14229 |  180083-23-2 | C32H32N4O3 | 520.633 | 6 / 0 | 5.6 | No |
| 14684 |  CHEMBL302882 | C21H19Br3N4O | 583.122 | 3 / 4 | 4.6 | No |
| 14973 |  CHEMBL434591 | C25H25N3O3S | 447.553 | 5 / 1 | 4.2 | Yes |
| 442232 |  EMETINE | C29H40N2O4 | 480.649 | 6 / 1 | 4.7 | Yes |
| 15263 |  CHEMBL356799 | C25H31FN4O | 422.548 | 3 / 1 | 3.9 | Yes |
| 15287 |  CHEMBL1256344 | C34H40N4O6 | 600.716 | 8 / 1 | 4.2 | No |
| 15340 |  CHEMBL291305 | C26H32N2O4 | 436.552 | 5 / 0 | 3.5 | Yes |
| 15359 |  CHEMBL95251 | C19H31NO2 | 305.462 | 3 / 1 | 4.0 | Yes |
| 464809 |  CHEMBL3609357 | C24H29N3 | 359.517 | 2 / 1 | 4.1 | Yes |
| 15923 |  CHEMBL40819 | C25H24N4O5S | 492.55 | 7 / 1 | 4.0 | Yes |
| 16601 |  CHEMBL253233 | C29H30N4OS | 482.646 | 5 / 1 | 5.7 | No |
| 16692 |  CHEMBL303988 | C25H31N3O4 | 437.54 | 6 / 1 | 3.4 | Yes |
| 16781 |  Pipamperone | C21H30FN3O2 | 375.488 | 5 / 1 | 2.0 | Yes |
| 16988 |  Metrenperone | C24H26FN3O2 | 407.489 | 5 / 0 | 2.7 | Yes |
| 17112 |  SCHEMBL977787 | C22H35Cl2N7O2 | 500.469 | 7 / 2 | 3.2 | No |
| 17149 |  CHEMBL2440659 | C15H11FN4O2S | 330.337 | 7 / 1 | 2.4 | Yes |
| 17880 |  Bmy-7378 | C22H31N3O3 | 385.508 | 5 / 0 | 2.8 | Yes |
| 19143 |  CHEMBL1255003 | C25H29NO3 | 391.511 | 4 / 1 | 5.3 | No |
| 442422 |  CHEMBL3415013 | C25H32N4O2 | 420.557 | 4 / 2 | 3.5 | Yes |
| 20193 |  imipramine | C19H24N2 | 280.415 | 2 / 0 | 4.8 | Yes |
| 21542 |  CHEMBL40780 | C26H24N4O3S | 472.563 | 6 / 1 | 3.9 | Yes |
| 21600 |  CHEMBL14213 | C26H28N4O3S | 476.595 | 6 / 0 | 4.1 | Yes |
| 22960 |  CHEMBL382972 | C26H31NO5 | 437.536 | 6 / 1 | 4.9 | Yes |
| 23014 |  CHEMBL417890 | C25H25N3O4 | 431.492 | 5 / 1 | 3.5 | Yes |
| 23228 |  CHEMBL43345 | C17H17NO2 | 267.328 | 3 / 3 | 2.5 | Yes |
| 23352 |  sulpiride | C15H23N3O4S | 341.426 | 6 / 2 | 0.6 | Yes |
| 555573 |  Phenethylamine | C8H11N | 121.183 | 1 / 1 | 1.4 | Yes |
| 442607 |  CHEMBL3342872 | C23H31N3O5S2 | 493.637 | 9 / 0 | 2.7 | Yes |
| 25050 |  CHEMBL42231 | C27H31NO3 | 417.549 | 4 / 1 | 5.5 | No |
| 25149 |  CHEMBL340641 | C24H26Cl2N4O | 457.399 | 4 / 1 | 5.3 | No |
| 442690 |  LISURIDE | C20H26N4O | 338.455 | 2 / 2 | 2.7 | Yes |
| 26553 |  Rauwolscine | C21H26N2O3 | 354.45 | 4 / 2 | 2.9 | Yes |
| 26597 |  Yohimbine | C21H26N2O3 | 354.45 | 4 / 2 | 2.9 | Yes |
| 26636 |  CHEBI:48565 | C21H26N2O3 | 354.45 | 4 / 2 | 2.9 | Yes |
| 442713 |  terconazole | C26H31Cl2N5O3 | 532.466 | 7 / 0 | 4.8 | No |
| 28323 |  CHEMBL252031 | C25H30N4OS | 434.602 | 5 / 1 | 4.6 | Yes |
| 29368 |  CHEMBL2153559 | C20H25NO6 | 375.421 | 7 / 1 | 2.9 | Yes |
| 442822 |  CHEMBL3415017 | C23H27BrN4O2 | 471.399 | 4 / 2 | 4.3 | Yes |
| 30125 |  CHEMBL495289 | C25H27NO3 | 389.495 | 4 / 1 | 4.0 | Yes |
| 30162 |  Metopimazine | C22H27N3O3S2 | 445.596 | 6 / 1 | 3.1 | Yes |
| 30253 |  CHEMBL111372 | C14H17N3O3S | 307.368 | 5 / 3 | 1.4 | Yes |
| 442842 |  CHEMBL3342856 | C19H29N3O3 | 347.459 | 6 / 1 | 1.4 | Yes |
| 30341 |  CHEMBL293539 | C21H27ClFN3O2 | 407.914 | 5 / 0 | 3.6 | Yes |
| 442868 |  CHEMBL3342855 | C19H28N2O5S | 396.502 | 7 / 0 | 1.2 | Yes |
| 31583 |  CHEMBL89380 | C21H34N4O | 358.53 | 5 / 0 | 3.0 | Yes |
| 32779 |  CHEMBL144901 | C25H29FN4O | 420.532 | 3 / 1 | 3.7 | Yes |
| 33392 |  CHEMBL420510 | C26H32N4O2 | 432.568 | 4 / 0 | 3.8 | Yes |
| 442994 |  CHEMBL3342866 | C25H33N3O5S | 487.615 | 8 / 0 | 2.7 | Yes |
| 34213 |  CHEMBL58384 | C21H27ClIN3O2 | 515.82 | 4 / 0 | 4.1 | No |
| 443024 |  CHEMBL3342873 | C20H31N3O5S | 425.544 | 8 / 0 | 1.1 | Yes |
| 34583 |  CHEMBL58803 | C23H28N4O | 376.504 | 3 / 1 | 4.0 | Yes |
| 34929 |  CHEMBL385371 | C26H30ClNO4 | 455.979 | 5 / 2 | N/A | N/A |
| 35801 |  CHEMBL299454 | C21H30ClN3O | 375.941 | 3 / 0 | 4.1 | Yes |
| 555614 |  Tetryzoline | C13H16N2 | 200.285 | 1 / 1 | 1.8 | Yes |
| 36203 |  CHEMBL144710 | C25H31FN4O | 422.548 | 3 / 1 | 3.9 | Yes |
| 37103 |  CHEMBL2115086 | C21H23N3O3S | 397.493 | 5 / 1 | 2.8 | Yes |
| 37106 |  CHEMBL291839 | C21H23N3O3S | 397.493 | 5 / 1 | 2.8 | Yes |
| 37451 |  CHEMBL313990 | C23H24ClN3O5S | 489.971 | 6 / 0 | 3.6 | Yes |
| 443187 |  Pecazine | C19H22N2S | 310.459 | 3 / 0 | 5.6 | No |
| 38115 |  Reboxetine | C19H23NO3 | 313.397 | 4 / 1 | 3.0 | Yes |
| 38245 |  CHEMBL541129 | C21H32Cl2FN3 | 416.406 | 3 / 3 | N/A | N/A |
| 39300 |  CHEMBL61598 | C25H28N4O4 | 448.523 | 5 / 2 | 2.0 | Yes |
| 39549 |  CHEMBL99503 | C17H26BrNO2 | 356.304 | 3 / 1 | 3.6 | Yes |
| 40978 |  CHEMBL145384 | C26H34ClN5O3 | 500.04 | 7 / 1 | 4.6 | No |
| 41110 |  CHEMBL1946781 | C28H29NO6 | 475.541 | 7 / 3 | N/A | N/A |
| 41698 |  L-765314 | C27H34N6O5 | 522.606 | 9 / 2 | 3.1 | No |
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