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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Alpha-1A adrenergic receptor
Species	Rattus norvegicus (Rat)
Gene	Adra1a
Synonym	alpha1c alpha1A-adrenoceptor alpha1a Alpha-1C adrenergic receptor Alpha-1A adrenoreceptor Alpha-1A adrenoceptor alpha-1A adrenergic receptor ADRA1C alpha 1C-adrenergic receptor alpha 1A-adrenoreceptor alpha 1A-adrenoceptor adrenergic receptor, alpha 1a adrenergic receptor alpha 1c adrenergic alpha 1c receptor ADRA1L1 [ Show all ]
Disease	N/A for non-human GPCRs
Length	466
Amino acid sequence	MVLLSENASEGSNCTHPPAPVNISKAILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWVLSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYVPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNVPAEGGGVSSAKNKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLRRRQSSKHALGYTLHPPSQALEGQHRDMVRIPVGSGETFYKISKTDGVCEWKFFSSMPQGSARITVPKDQSACTTARVRSKSFLQVCCCVGSSAPRPEENHQVPTIKIHTISLGENGEEV
UniProt	P43140
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL319
IUPHAR	22
DrugBank	N/A

Ligand

Name	Tetryzoline
Molecular formula	C13H16N2
IUPAC name	2-(1,2,3,4-tetrahydronaphthalen-1-yl)-4,5-dihydro-1H-imidazole
Molecular weight	200.285
Hydrogen bond acceptor	1
Hydrogen bond donor	1
XlogP	1.8
Synonyms	KB-61571 Lopac0_001137 NCGC00016018-07 (RS)-2-(1,2,3,4-tetrahydronaphthalen-1-yl)-4,5-dihydro-1H-imidazole rac-2-(1,2,3,4-tetrahydro-1-naphthyl)-2-imidazoline 2-(1,2,3,4-tetrahydronaphthalen-1-yl)-4,5-dihydro-1H-imidazole;hydrochloride Spectrum5_001022 522-48-5 (mono-hydrochloride) Tetrizolina AKOS017258508 Tetryzolinum [INN-Latin] BSPBio_000855 CHEBI:28674 DivK1c_000854 KBio2_004084 MCULE-1878887684 Opticlear 1H-imidazole, 4,5-dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)-, hydrochloride SPBio_001459 2-tetralin-1-yl-2-imidazoline;hydrochloride STL163582 tetryzolina BDBM96559 Visine C-23911 cid_10648 FT-0690208 I14-11411 KBioGR_001561 NCGC00016018-03 Prestwick2_000698 2-(1,2,3,4-Tetrahydro-1-naphthyl)-2-imidazoline Spectrum3_000582 4,5-Dihydro-2-(1,2,3,4-tetrahydro-1-naphthyl)-1H-imidazole tetrahydrozoline, (+-)-isomer AC1L1KBE Tetryzoline [INN:BAN] BRD-A28856712-003-15-3 CC-34953 KBio1_000854 LS-176618 NCGC00089820-02 084T220 SBI-0051104.P004 2-(1,2,3,4-tetrahydronaphthyl)-2-imidazoline Spectrum_001036 67731-52-6 Tetrizolina [INN-Spanish] ALBB-023224 Tyzanol BSPBio_002024 DTXSID1047861 HMS3561J13 KBio2_006652 MolPort-001-684-719 Prestwick0_000698 1H-Imidazole,4,5-dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)- SPBio_002776 2-Tetralin-1-yl-4,5-dihydro-1H-imidazole teetryzoline AB00053551_11 BPBio1_000941 ZX-AN021738 C07912 D05IHU IDI1_000854 KBioSS_001516 NCGC00016018-04 Prestwick3_000698 2-(1,2,3,4-tetrahydronaphthalen-1-yl)-4,5-dihydro-1H-imidazole Spectrum4_000871 5-23-07-00394 (Beilstein Handbook Reference) Tetrahydrozolinum AKOS003659212 Tetryzolinum BRN 0011442 CCG-202845 DB06764 KBio2_001516 LS-79680 NINDS_000854 1H-Imidazole, 4,5-dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)- SCHEMBL34760 2-IMIDAZOLINE, 2-(1,2,3,4-TETRAHYDRO-1-NAPHTHYL)- ST024759 84-22-0 Tetryzolin AN-42275 Tyzine BYJAVTDNIXVSPW-UHFFFAOYSA-N CHEMBL1266 EINECS 201-522-3 HSDB 7471 KBio3_001524 MRF-0000521 Prestwick1_000698 2-(1,2,3,4-Tetrahydro-1-naphthalenyl)-4,5-dihydro-1H-imidazole Spectrum2_001330 4,5-dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)-1H-imidazole tetrahydrozoline AB00053551_12 Tetryzoline (INN) BRD-A28856712-003-05-4 Caltheon (TN) D08578 [ Show all ]
Inchi Key	BYJAVTDNIXVSPW-UHFFFAOYSA-N
Inchi ID	InChI=1S/C13H16N2/c1-2-6-11-10(4-1)5-3-7-12(11)13-14-8-9-15-13/h1-2,4,6,12H,3,5,7-9H2,(H,14,15)
PubChem CID	5419
ChEMBL	CHEMBL1266
IUPHAR	N/A
BindingDB	96559
DrugBank	DB06764
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	11.0 nM	PMID17827	BindingDB
Ki	300.0 nM	PMID17827	BindingDB

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