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| Name | 5-hydroxytryptamine receptor 2B |
|---|---|
| Species | Homo sapiens (Human) |
| Gene | HTR2B |
| Synonym | stomach fundus serotonin receptor serotonin receptor 2B 5-HT2F 5-HT-2B 5-HT2B [ Show all ] |
| Disease | Psychoses Migraine Irritable bowel syndrome Depression; Cerebral infarction Coronary heart disease [ Show all ] |
| Length | 481 |
| Amino acid sequence | MALSYRVSELQSTIPEHILQSTFVHVISSNWSGLQTESIPEEMKQIVEEQGNKLHWAALLILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDETLMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNPMAENSKFFKKHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLLTENEGDKTEEQVSYV |
| UniProt | P41595 |
| Protein Data Bank | 5tud, 5tvn, 6drx, 4ib4, 4nc3, 6dry, 6drz, 6ds0 |
| GPCR-HGmod model | P41595 |
| 3D structure model | This structure is from PDB ID 5tud. |
| BioLiP | BL0425280, BL0425283, BL0425282, BL0239858, BL0239859, BL0265182, BL0265183, BL0368464, BL0425281, BL0385686,BL0385687, BL0425284, BL0425285, BL0425286, BL0368465, BL0425287 |
| Therapeutic Target Database | T31204 |
| ChEMBL | CHEMBL1833 |
| IUPHAR | 7 |
| DrugBank | BE0000393 |
You can:
| GLASS ID | Molecule | Formula | Molecular weight | H-bond acceptor / donor | XlogP | Lipinski's druglikeness |
|---|---|---|---|---|---|---|
| 141 |  CHEMBL187888 | C13H15N3 | 213.284 | 3 / 1 | 1.6 | Yes |
| 342 |  CHEMBL475382 | C17H19ClN2O | 302.802 | 2 / 3 | N/A | N/A |
| 521457 |  CHEMBL3818128 | C19H23ClFN | 319.848 | 2 / 1 | N/A | N/A |
| 1010 |  CHEMBL2205816 | C18H20N2O | 280.371 | 3 / 1 | 1.8 | Yes |
| 1266 |  CHEMBL493129 | C11H16ClNO | 213.705 | 2 / 2 | N/A | N/A |
| 1362 |  CHEMBL2337104 | C15H19ClN2O | 278.78 | 2 / 3 | N/A | N/A |
| 1563 |  hexachlorophene | C13H6Cl6O2 | 406.889 | 2 / 2 | 7.5 | No |
| 441752 |  CHEMBL3416041 | C14H19Cl2NO | 288.212 | 2 / 2 | N/A | N/A |
| 441754 |  CHEMBL3416040 | C14H19Cl2NO | 288.212 | 2 / 2 | N/A | N/A |
| 2165 |  CHEMBL598444 | C23H24N4O2S | 420.531 | 5 / 1 | 4.3 | Yes |
| 2167 |  CHEMBL597009 | C23H24N4O2S | 420.531 | 5 / 1 | 4.3 | Yes |
| 2184 |  CHEMBL458002 | C29H28ClN5O2 | 514.026 | 5 / 2 | 4.3 | No |
| 2218 |  CHEMBL501896 | C17H17ClF3N | 327.775 | 4 / 2 | N/A | N/A |
| 2283 |  1-(cyclohexylmethyl)pyrrolidine | C11H21N | 167.296 | 1 / 0 | 3.1 | Yes |
| 2334 |  CHEMBL249797 | C24H28N4O2S | 436.574 | 6 / 2 | 3.9 | Yes |
| 2952 |  CHEMBL2337496 | C12H13ClN2O | 236.699 | 2 / 2 | 1.4 | Yes |
| 521531 |  CHEMBL3818805 | C24H27ClN4O | 422.957 | 2 / 2 | 4.8 | Yes |
| 3400 |  CHEMBL1642882 | C18H19ClN4O2S | 390.886 | 5 / 3 | 3.4 | Yes |
| 3594 |  2-Phenylcyclopropanamine | C9H11N | 133.194 | 1 / 1 | 1.5 | Yes |
| 3607 |  SCHEMBL3561492 | C13H16N2O | 216.284 | 2 / 1 | 1.3 | Yes |
| 3610 |  SCHEMBL3555280 | C13H16N2O | 216.284 | 2 / 1 | 1.3 | Yes |
| 3618 |  CHEMBL360492 | C11H13ClFN | 213.68 | 2 / 1 | 2.8 | Yes |
| 557389 |  Pulicatins F | C10H8N2O2S | 220.246 | 4 / 2 | 1.5 | Yes |
| 4098 |  CHEMBL1173578 | C21H16ClN5O2S2 | 469.962 | 7 / 0 | 4.6 | Yes |
| 4301 |  Butanedioic acid, compd. with 5-methoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole (1:1) | C18H22N2O5 | 346.383 | 6 / 4 | N/A | N/A |
| 4327 |  sulconazole | C18H15Cl3N2S | 397.742 | 2 / 0 | 6.1 | No |
| 521573 |  CHEMBL3735911 | C29H35NO5 | 477.601 | 6 / 0 | 6.2 | No |
| 4811 |  CHEMBL376456 | C12H14N2O2 | 218.256 | 3 / 1 | 0.3 | Yes |
| 5104 |  CHEMBL55207 | C20H16Cl2N4O2 | 415.274 | 4 / 1 | 4.0 | Yes |
| 5162 |  CHEMBL220521 | C12H13ClN2O2 | 252.698 | 3 / 1 | 0.9 | Yes |
| 5248 |  SB-258719 | C18H30N2O2S | 338.51 | 4 / 0 | 3.5 | Yes |
| 5262 |  CHEMBL299726 | C20H17ClN4O2 | 380.832 | 4 / 1 | 3.5 | Yes |
| 5686 |  AC1L1HUK | C29H28ClN3O4 | 518.01 | 4 / 2 | 5.2 | No |
| 5743 |  AHOUBRCZNHFOSL-UHFFFAOYSA-N | C19H20FNO3 | 329.371 | 5 / 1 | 3.5 | Yes |
| 5768 |  paroxetine | C19H20FNO3 | 329.371 | 5 / 1 | 3.5 | Yes |
| 6437 |  CHEMBL567587 | C16H16N4O | 280.331 | 4 / 1 | 0.5 | Yes |
| 441965 |  CID 118733771 | C15H19ClF3NO3 | 353.766 | 7 / 2 | N/A | N/A |
| 441968 |  CID 118733773 | C15H19ClF3NO3 | 353.766 | 7 / 2 | N/A | N/A |
| 6764 |  CHEMBL404581 | C21H20FN3 | 333.41 | 4 / 1 | 3.7 | Yes |
| 6800 |  CHEMBL577831 | C17H21ClN4O | 332.832 | 4 / 1 | 1.7 | Yes |
| 463708 |  CHEMBL3633757 | C26H24BrNO4 | 494.385 | 5 / 0 | 5.4 | No |
| 6984 |  CHEMBL493129 | C11H15NO | 177.247 | 2 / 1 | 1.4 | Yes |
| 536134 |  CHEMBL3899832 | C22H19N5O4 | 417.425 | 8 / 2 | 3.6 | Yes |
| 7144 |  CHEMBL234532 | C23H26Cl2N2O3 | 449.372 | 4 / 0 | 5.0 | Yes |
| 7598 |  CHEMBL233440 | C26H31N3O4 | 449.551 | 5 / 1 | 3.3 | Yes |
| 7697 |  792173-99-0 | C17H13N5O2 | 319.324 | 5 / 2 | 2.0 | Yes |
| 7824 |  CHEMBL469668 | C20H29F3N2O2 | 386.459 | 7 / 1 | 3.9 | Yes |
| 8195 |  BW-723C86 | C16H18N2OS | 286.393 | 3 / 2 | 3.0 | Yes |
| 521700 |  CHEMBL3754496 | C16H19FN2 | 258.34 | 2 / 1 | 2.9 | Yes |
| 536192 |  CHEMBL3947432 | C14H20N2O | 232.327 | 3 / 1 | 2.2 | Yes |
| 8911 |  CHEMBL181324 | C12H17NO | 191.274 | 2 / 1 | 2.1 | Yes |
| 9430 |  CHEMBL2397891 | C15H18N2O | 242.322 | 2 / 1 | 1.7 | Yes |
| 9541 |  GSK163090 | C25H29N5O | 415.541 | 4 / 1 | 3.4 | Yes |
| 9881 |  AC-42 | C20H31NO | 301.474 | 2 / 0 | 5.2 | No |
| 9992 |  CHEMBL1224032 | C14H17FN2O2S | 296.36 | 4 / 1 | 2.3 | Yes |
| 553299 |  BF-1 | C22H25NO2S | 367.507 | 4 / 0 | 4.2 | Yes |
| 10563 |  CHEMBL1277492 | C24H24ClNO4 | 425.909 | 5 / 1 | 2.1 | Yes |
| 10701 |  CHEMBL213006 | C23H26ClN3O | 395.931 | 4 / 0 | 5.2 | No |
| 10726 |  CHEMBL3287723 | C25H32O7 | 444.524 | 7 / 2 | 5.7 | No |
| 10889 |  CHEMBL396748 | C24H27F3N2O3 | 448.486 | 7 / 0 | 4.7 | Yes |
| 11057 |  tryptamine | C10H12N2 | 160.22 | 1 / 2 | 1.6 | Yes |
| 11622 |  CHEMBL568693 | C14H17N3O | 243.31 | 3 / 2 | 1.2 | Yes |
| 11693 |  Propranolol, L- | C16H21NO2 | 259.349 | 3 / 2 | 3.0 | Yes |
| 11711 |  DEXPROPRANOLOL | C16H21NO2 | 259.349 | 3 / 2 | 3.0 | Yes |
| 11729 |  propranolol | C16H21NO2 | 259.349 | 3 / 2 | 3.0 | Yes |
| 11855 |  CHEMBL280297 | C28H22F3N3O2 | 489.498 | 6 / 1 | 5.7 | No |
| 12251 |  CHEMBL52919 | C23H21F3N4O2 | 442.442 | 7 / 1 | 4.5 | Yes |
| 12440 |  CHEMBL2397902 | C13H16N2O2 | 232.283 | 3 / 1 | 0.8 | Yes |
| 13160 |  CHEMBL492926 | C10H12FN | 165.211 | 2 / 1 | 1.5 | Yes |
| 13644 |  8-OH-Dpat | C16H25NO | 247.382 | 2 / 1 | 4.1 | Yes |
| 521869 |  CHEMBL3771373 | C15H21N5 | 271.368 | 2 / 3 | 2.0 | Yes |
| 14237 |  180083-23-2 | C32H32N4O3 | 520.633 | 6 / 0 | 5.6 | No |
| 14270 |  CHEMBL2337501 | C12H14Cl2N2O | 273.157 | 2 / 3 | N/A | N/A |
| 14314 |  CHEMBL452719 | C10H13N | 147.221 | 1 / 1 | 1.7 | Yes |
| 14317 |  15639-87-9 | C10H13N | 147.221 | 1 / 1 | 1.7 | Yes |
| 14320 |  CHEMBL449134 | C10H13N | 147.221 | 1 / 1 | 1.7 | Yes |
| 14323 |  CHEMBL442657 | C10H13N | 147.221 | 1 / 1 | 1.7 | Yes |
| 14446 |  CHEMBL3286560 | C16H19N3O | 269.348 | 4 / 1 | 2.4 | Yes |
| 14551 |  CHEMBL2397882 | C12H14N2O | 202.257 | 2 / 1 | 0.8 | Yes |
| 14553 |  SCHEMBL5458020 | C12H14N2O | 202.257 | 2 / 1 | 0.8 | Yes |
| 14805 |  CHEMBL605971 | C22H22N4O2S | 406.504 | 5 / 1 | 3.3 | Yes |
| 15005 |  CHEMBL383051 | C13H19N3O | 233.315 | 4 / 1 | 0.9 | Yes |
| 15098 |  disulfiram | C10H20N2S4 | 296.524 | 4 / 0 | 3.9 | Yes |
| 15178 |  CHEMBL2022193 | C14H20ClNO | 253.77 | 2 / 2 | N/A | N/A |
| 15180 |  CHEMBL2022189 | C14H20ClNO | 253.77 | 2 / 2 | N/A | N/A |
| 15214 |  CHEMBL2334981 | C24H26ClN5OS | 468.016 | 5 / 2 | N/A | N/A |
| 521909 |  CHEMBL3819567 | C24H28N4OS | 420.575 | 5 / 1 | 4.8 | Yes |
| 15470 |  CHEMBL2205829 | C19H19NO3 | 309.365 | 4 / 1 | 2.2 | Yes |
| 442285 |  CHEMBL3321789 | C22H25ClFNO2 | 389.895 | 4 / 1 | 4.8 | Yes |
| 521940 |  AM-0902 | C17H15ClN6O2 | 370.797 | 6 / 0 | 2.3 | Yes |
| 442289 |  CHEMBL3343673 | C18H17N3O2 | 307.353 | 2 / 2 | 2.2 | Yes |
| 442292 |  CHEMBL3343672 | C18H17N3O2 | 307.353 | 2 / 2 | 2.2 | Yes |
| 16798 |  Pipamperone | C21H30FN3O2 | 375.488 | 5 / 1 | 2.0 | Yes |
| 16875 |  Glemanserin | C20H25NO | 295.426 | 2 / 1 | 3.8 | Yes |
| 17040 |  CHEMBL492926 | C10H13ClFN | 201.669 | 2 / 2 | N/A | N/A |
| 548084 |  CHEMBL3952251 | C20H23Cl2NO | 364.31 | 2 / 1 | N/A | N/A |
| 17153 |  CHEMBL2440659 | C15H11FN4O2S | 330.337 | 7 / 1 | 2.4 | Yes |
| 521985 |  CHEMBL3775473 | C23H19FN2O4S2 | 470.533 | 7 / 1 | 4.2 | Yes |
| 17596 |  CHEMBL475642 | C12H17N | 175.275 | 1 / 1 | 2.2 | Yes |
| 17857 |  CHEMBL1278113 | C24H28N2O2 | 376.5 | 4 / 2 | 1.6 | Yes |
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