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GPCR

Name	5-hydroxytryptamine receptor 2B
Species	Homo sapiens (Human)
Gene	HTR2B
Synonym	stomach fundus serotonin receptor serotonin receptor 2B 5-HT2F 5-HT-2B 5-HT2B 5-HT2B receptor 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled [ Show all ]
Disease	Psychoses Migraine Irritable bowel syndrome Depression; Cerebral infarction Coronary heart disease Congestive heart failure Pulmonary arterial hypertension [ Show all ]
Length	481
Amino acid sequence	MALSYRVSELQSTIPEHILQSTFVHVISSNWSGLQTESIPEEMKQIVEEQGNKLHWAALLILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDETLMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNPMAENSKFFKKHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLLTENEGDKTEEQVSYV
UniProt	P41595
Protein Data Bank	5tud, 5tvn, 6drx, 4ib4, 4nc3, 6dry, 6drz, 6ds0
GPCR-HGmod model	P41595
3D structure model	This structure is from PDB ID 5tud.
BioLiP	BL0425280, BL0425283, BL0425282, BL0239858, BL0239859, BL0265182, BL0265183, BL0368464, BL0425281, BL0385686,BL0385687, BL0425284, BL0425285, BL0425286, BL0368465, BL0425287
Therapeutic Target Database	T31204
ChEMBL	CHEMBL1833
IUPHAR	7
DrugBank	BE0000393

Ligand

Name	2-Phenylcyclopropanamine
Molecular formula	C9H11N
IUPAC name	2-phenylcyclopropan-1-amine
Molecular weight	133.194
Hydrogen bond acceptor	1
Hydrogen bond donor	1
XlogP	1.5
Synonyms	Lopac0_001013 NSC-80664 (-)-Tranylcypromine Racemic Tranylcypromine (2S)-2-phenylcyclopropan-1-amine SmithKline Brand of Tranylcypromine Sulfate trans 2 Phenylcyclopropylamine Allphar Brand of Tranylcypromine Sulfate tranylcypromine US8609708, 6 Tranyl- cypromine Cyclopropylamine, trans-(.+-.)- F2173-0870 KBio2_002078 NCGC00015848-02 Parnate (.+/-.)-Tranylcypromine SCHEMBL40651 2-PCPA Spectrum5_001829 AC1L1KJT trans-DL-2-Phenylcyclopropylamine BS-13286 Tranylcypromine,(+) Cyclopropanamine, 2-phenyl- DB00752 Goldshield Brand of Tranylcypromine Sulfate KBio3_001876 l-Tranylcypromine NCGC00162316-01 (+/-)-trans-2-phenylcyclopropylamine Parnitene (1S)-2-phenylcyclopropan-1-amine SKF Trans-385 Tranilcipromina AELCINSCMGFISI-UHFFFAOYSA-N Transapin (TN) CCRIS 3344 Tranylcyprominum [INN-Latin] Cyclopropanamine, trans-(.+-.)- EN300-54719 Jatrosom LS-58824 NSC80664 (.+/-.)-trans-2-Phenylcyclopropamine SBB084038 Spectrum3_001068 54-97-7 trans-(-)-2-Phenylcyclopropanamine BDBM50113851 Tranylcypromine (INN) CHEMBL313833 US8609708, 6 Tranylcypromine Cyclopropylamine, trans-2-phenyl- GJZ KBio2_004646 NCGC00015848-03 (+)-trans-2-Phenylcyclopropylamine Parnate (Salt/Mix) (1R,2S)-2-phenylcyclopropan-1-amine Sicoton (TN) 2-Phenyl-cyclopropylamine Spectrum_001598 AC1Q1HO9 Transamine C9H11N Tranylcypromine,(-) Cyclopropanamine, 2-phenyl-, (1R-trans)-(9CI) dl-Tranylcypromine GTPL5281 KBioGR_001658 Link Brand of Tranylcypromine Sulfate NSC 80664 (+/-)-Tranylcypromine Parstelin (TN) (1S,2S)-2-phenylcyclopropan-1-amine SKF-trans-385 2-phenylcyclopropylamine Tranilcipromina [INN-Spanish] AKOS005217104 Tranylcypromin CHEBI:131512 Tylciprine (TN) Cyclopropylamine, 2-phenyl-, trans-(+-)- esparma Brand of Tranylcypromine Sulfate Jatrosom (TN) MCULE-7015811838 Parmodalin (TN) (.+/-.)-trans-2-Phenylcyclopropylamine SC-66350 2- Amino-cyclopropylbenzene Spectrum4_001219 AB01007711-01 trans-2-Phenylcyclopropylamine BRN 3195803 Tranylcypromine [INN:BAN] CTK1F7780 D0H0HJ GlaxoSmithKline Brand of Tranylcypromine Sulfate KBio2_007214 NCGC00015848-04 (+)-Tranylcypromine Parnate (TN) (1R,2R)-2-phenylcyclopropan-1-amine SKF 385 2-phenylcyclopropan-1-amine Sulfate, Tranylcypromine AC1Q53BI Transamine (TN) CCG-40399 Tranylcyprominum Cyclopropanamine, 2-phenyl-, trans-(+-)- EINECS 205-841-9 HSDB 3404 KBioSS_002078 [ Show all ]
Inchi Key	AELCINSCMGFISI-UHFFFAOYSA-N
Inchi ID	InChI=1S/C9H11N/c10-9-6-8(9)7-4-2-1-3-5-7/h1-5,8-9H,6,10H2
PubChem CID	5530
ChEMBL	CHEMBL313833
IUPHAR	N/A
BindingDB	50113851
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	<5000.0 nM	PMID19284718	BindingDB,ChEMBL
Emax	29.0 %	PMID19284718	ChEMBL

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