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| Name | Alpha-1D adrenergic receptor |
|---|---|
| Species | Homo sapiens (Human) |
| Gene | ADRA1D |
| Synonym | alpha1a/d-adrenoceptor adrenergic receptor delta1 Gpcr8 Adrd1 ADRA1R [ Show all ] |
| Disease | Urinary incontinence Benign prostatic hyperplasia Congestive heart failure Diabetes Erectile dysfunction [ Show all ] |
| Length | 572 |
| Amino acid sequence | MTFRDLLSVSFEGPRPDSSAGGSSAGGGGGSAGGAAPSEGPAVGGVPGGAGGGGGVVGAGSGEDNRSSAGEPGSAGAGGDVNGTAAVGGLVVSAQGVGVGVFLAAFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVLGFWAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWVVALVVSVGPLLGWKEPVPPDERFCGITEEAGYAVFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGVKRERGKASEVVLRIHCRGAATGADGAHGMRSAKGHTFRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRRRRPLWRVYGHHWRASTSGLRQDCAPSSGDAPPGAPLALTALPDPDPEPPGTPEMQAPVASRRKPPSAFREWRLLGPFRRPTTQLRAKVSSLSHKIRAGGAQRAEAACAQRSEVEAVSLGVPHEVAEGATCQAYELADYSNLRETDI |
| UniProt | P25100 |
| Protein Data Bank | N/A |
| GPCR-HGmod model | N/A |
| 3D structure model | No available structures or models |
| BioLiP | N/A |
| Therapeutic Target Database | T53381 |
| ChEMBL | CHEMBL223 |
| IUPHAR | 24 |
| DrugBank | BE0004863, BE0000715 |
You can:
| GLASS ID | Molecule | Formula | Molecular weight | H-bond acceptor / donor | XlogP | Lipinski's druglikeness |
|---|---|---|---|---|---|---|
| 63 |  CHEMBL309518 | C24H27N3O5S2 | 501.616 | 7 / 0 | 3.5 | No |
| 79 |  CHEMBL287791 | C28H32F3N3O2 | 499.578 | 6 / 1 | 3.9 | Yes |
| 908 |  CHEMBL342126 | C34H34F4N4O4 | 638.664 | 9 / 2 | 6.1 | No |
| 521476 |  CHEMBL3797382 | C15H16ClN3O | 289.763 | 2 / 2 | 2.2 | Yes |
| 1934 |  CHEMBL93843 | C29H29F3N6O2 | 550.586 | 8 / 1 | 2.5 | No |
| 2010 |  CHEMBL90421 | C27H31F3N4O2 | 500.566 | 6 / 2 | 3.6 | No |
| 2012 |  CHEMBL328268 | C27H31F3N4O2 | 500.566 | 6 / 2 | 3.6 | No |
| 2255 |  1-(cyclohexylmethyl)pyrrolidine | C11H21N | 167.296 | 1 / 0 | 3.1 | Yes |
| 3039 |  CHEMBL1255085 | C23H25NO5 | 395.455 | 6 / 3 | 3.9 | Yes |
| 441855 |  CHEMBL3342860 | C27H32F3N3O4 | 519.565 | 9 / 0 | 3.9 | No |
| 4350 |  SCHEMBL6972355 | C16H20N2O4S | 336.406 | 6 / 3 | N/A | N/A |
| 4496 |  CID 44417700 | C24H26ClNO4 | 427.925 | 5 / 1 | N/A | N/A |
| 4505 |  CHEMBL215151 | C24H26ClNO4 | 427.925 | 5 / 2 | N/A | N/A |
| 463723 |  CHEMBL3633757 | C26H24BrNO4 | 494.385 | 5 / 0 | 5.4 | No |
| 7235 |  CHEMBL1796042 | C25H30N4O5 | 466.538 | 7 / 0 | 2.7 | Yes |
| 442018 |  CHEMBL3342852 | C19H28N2O3S | 364.504 | 6 / 0 | 2.5 | Yes |
| 521682 |  CHEMBL3754496 | C16H19FN2 | 258.34 | 2 / 1 | 2.9 | Yes |
| 8642 |  CHEMBL55629 | C22H27F3N4O3 | 452.478 | 8 / 1 | 2.9 | Yes |
| 536197 |  CHEMBL27021 | C19H24N2O | 296.414 | 3 / 0 | 3.8 | Yes |
| 8782 |  CHEMBL220515 | C24H26ClN5O2 | 451.955 | 5 / 1 | 3.6 | Yes |
| 9871 |  AC-42 | C20H31NO | 301.474 | 2 / 0 | 5.2 | No |
| 10048 |  Abanoquil | C22H25N3O4 | 395.459 | 7 / 1 | 3.4 | Yes |
| 10265 |  CHEMBL145587 | C30H38F2N4O3 | 540.656 | 8 / 0 | 4.3 | No |
| 10276 |  CHEMBL170960 | C10H12N2S | 192.28 | 2 / 1 | 2.4 | Yes |
| 10727 |  CHEMBL3287723 | C25H32O7 | 444.524 | 7 / 2 | 5.7 | No |
| 10779 |  CHEMBL1242445 | C26H33N3O4 | 451.567 | 6 / 0 | 2.4 | Yes |
| 10787 |  CHEMBL1242444 | C26H33N3O4 | 451.567 | 6 / 0 | 2.4 | Yes |
| 11277 |  CHEMBL1946783 | C31H34N2O6 | 530.621 | 8 / 2 | N/A | No |
| 11357 |  CHEMBL18303 | C16H21N5 | 283.379 | 3 / 2 | 1.6 | Yes |
| 11528 |  3-MPPI | C23H25N5O3 | 419.485 | 5 / 2 | 2.7 | Yes |
| 12636 |  CHEMBL98168 | C25H25NO2 | 371.48 | 3 / 0 | 5.4 | No |
| 12808 |  CHEMBL145894 | C36H40F2N4O4 | 630.737 | 7 / 2 | 6.6 | No |
| 13391 |  CHEMBL97859 | C15H21N3O2 | 275.352 | 4 / 2 | 2.7 | Yes |
| 13664 |  8-OH-Dpat | C16H25NO | 247.382 | 2 / 1 | 4.1 | Yes |
| 14040 |  CHEMBL326837 | C15H19N3O2 | 273.336 | 3 / 1 | 1.8 | Yes |
| 14353 |  CHEMBL1203847 | C9H11ClN2S | 214.711 | 2 / 2 | N/A | N/A |
| 14901 |  CHEMBL193620 | C21H26F3N3O2 | 409.453 | 7 / 0 | 3.1 | Yes |
| 15296 |  CHEMBL70095 | C33H38N4O7 | 602.688 | 9 / 2 | 3.5 | No |
| 15325 |  CHEMBL271913 | C27H37ClN4O3 | 501.068 | 5 / 2 | 5.3 | No |
| 15793 |  CHEMBL142718 | C28H33F2N7O4 | 569.614 | 8 / 4 | 1.9 | No |
| 16533 |  CHEMBL18256 | C14H17N5 | 255.325 | 3 / 2 | 0.7 | Yes |
| 548072 |  Pipamperone | C21H30FN3O2 | 375.488 | 5 / 1 | 2.0 | Yes |
| 16923 |  CHEMBL53675 | C21H26F4N4O3 | 458.458 | 9 / 1 | 3.2 | Yes |
| 17142 |  CHEMBL2440659 | C15H11FN4O2S | 330.337 | 7 / 1 | 2.4 | Yes |
| 17201 |  CHEMBL142383 | C30H35N5O8 | 593.637 | 9 / 2 | 3.4 | No |
| 17451 |  SCHEMBL1276324 | C24H26F2N4O2 | 440.495 | 7 / 2 | 4.3 | Yes |
| 17877 |  CHEMBL267336 | C26H29F4N3O5S | 571.588 | 12 / 1 | 4.0 | No |
| 17886 |  Bmy-7378 | C22H31N3O3 | 385.508 | 5 / 0 | 2.8 | Yes |
| 18687 |  SK&F-106686 | C14H16ClNS | 265.799 | 2 / 0 | 4.3 | Yes |
| 19141 |  CHEMBL1255003 | C25H29NO3 | 391.511 | 4 / 1 | 5.3 | No |
| 19341 |  CHEMBL432192 | C15H22N4O | 274.368 | 3 / 3 | 2.1 | Yes |
| 536472 |  CHEMBL3957222 | C28H28N2O3 | 440.543 | 4 / 1 | 4.9 | Yes |
| 19852 |  CHEMBL521096 | C24H28FN5O2 | 437.519 | 7 / 2 | 3.9 | Yes |
| 20052 |  CHEMBL72768 | C11H14FN3S | 239.312 | 4 / 2 | 1.5 | Yes |
| 20200 |  imipramine | C19H24N2 | 280.415 | 2 / 0 | 4.8 | Yes |
| 21832 |  BDBM50081825 | C38H46N6O4 | 650.824 | 7 / 3 | 4.3 | No |
| 22206 |  CHEMBL501404 | C15H12FN3O | 269.279 | 4 / 0 | 1.9 | Yes |
| 22424 |  CHEMBL75808 | C24H34N6O2 | 438.576 | 7 / 1 | 1.8 | Yes |
| 522227 |  CHEMBL3800506 | C14H13Cl2N3O3S | 374.236 | 4 / 2 | 1.3 | Yes |
| 22958 |  CHEMBL382972 | C26H31NO5 | 437.536 | 6 / 1 | 4.9 | Yes |
| 23117 |  CHEMBL1945292 | C21H27N3O4S | 417.524 | 7 / 5 | 1.2 | Yes |
| 23422 |  BDBM50090015 | C27H28F3N5O2 | 511.549 | 7 / 2 | 3.2 | No |
| 23439 |  CHEMBL41677 | C32H38N2O3 | 498.667 | 4 / 1 | 5.8 | No |
| 548160 |  Arotinolol | C15H21N3O2S3 | 371.532 | 7 / 3 | 2.3 | Yes |
| 442602 |  CHEMBL3342872 | C23H31N3O5S2 | 493.637 | 9 / 0 | 2.7 | Yes |
| 25052 |  CHEMBL42231 | C27H31NO3 | 417.549 | 4 / 1 | 5.5 | No |
| 25058 |  CHEMBL81486 | C24H28ClN5O2 | 453.971 | 6 / 1 | 3.9 | Yes |
| 26047 |  LISURIDE | C20H26N4O | 338.455 | 2 / 2 | 2.7 | Yes |
| 26055 |  S-(-)-Lisuride | C20H26N4O | 338.455 | 2 / 2 | 2.7 | Yes |
| 26074 |  AC1L1H1T | C20H26N4O | 338.455 | 2 / 2 | 2.7 | Yes |
| 26482 |  CHEMBL342347 | C31H39F2N5O3 | 567.682 | 8 / 1 | 3.7 | No |
| 26484 |  CHEMBL358313 | C31H39F2N5O3 | 567.682 | 8 / 1 | 3.7 | No |
| 26555 |  Rauwolscine | C21H26N2O3 | 354.45 | 4 / 2 | 2.9 | Yes |
| 26570 |  corynanthine | C21H26N2O3 | 354.45 | 4 / 2 | 2.9 | Yes |
| 26592 |  Yohimbine | C21H26N2O3 | 354.45 | 4 / 2 | 2.9 | Yes |
| 26645 |  CHEBI:48565 | C21H26N2O3 | 354.45 | 4 / 2 | 2.9 | Yes |
| 26943 |  terconazole | C26H31Cl2N5O3 | 532.466 | 7 / 0 | 4.8 | No |
| 27073 |  CHEMBL258007 | C13H14N2 | 198.269 | 1 / 1 | 2.7 | Yes |
| 27180 |  CHEMBL2203713 | C18H22N4S | 326.462 | 4 / 2 | 2.9 | Yes |
| 27516 |  CHEMBL2432063 | C19H29N | 271.448 | 1 / 0 | 4.7 | Yes |
| 28153 |  CHEMBL1796029 | C23H26ClN3O2 | 411.93 | 4 / 0 | 3.2 | Yes |
| 548196 |  Lorpiprazole | C21H26F3N5 | 405.469 | 7 / 0 | 3.3 | Yes |
| 29195 |  CHEMBL170201 | C10H12N2S | 192.28 | 2 / 1 | 2.4 | Yes |
| 29364 |  CHEMBL2153559 | C20H25NO6 | 375.421 | 7 / 1 | 2.9 | Yes |
| 29372 |  CHEMBL2153560 | C20H25NO6 | 375.421 | 7 / 1 | 2.9 | Yes |
| 29660 |  CID 10903225 | C13H20ClN3O2S | 317.832 | 5 / 2 | N/A | N/A |
| 558173 |  CHEMBL283350 | C18H14N4O6 | 382.332 | 8 / 3 | 1.2 | Yes |
| 29846 |  CHEMBL13789 | C16H16N2O | 252.317 | 2 / 1 | 2.5 | Yes |
| 30121 |  CHEMBL495289 | C25H27NO3 | 389.495 | 4 / 1 | 4.0 | Yes |
| 442845 |  CHEMBL3342856 | C19H29N3O3 | 347.459 | 6 / 1 | 1.4 | Yes |
| 442870 |  CHEMBL3342855 | C19H28N2O5S | 396.502 | 7 / 0 | 1.2 | Yes |
| 522491 |  CHEMBL3809630 | C25H31F4N3O4 | 513.534 | 10 / 3 | 3.7 | No |
| 31843 |  CHEMBL1945289 | C26H29N3O4S | 479.595 | 7 / 5 | 2.8 | Yes |
| 32187 |  CHEMBL420184 | C22H29N3O2S | 399.553 | 5 / 0 | 2.8 | Yes |
| 548281 |  CHEMBL3984249 | C21H20N2O3 | 348.402 | 4 / 1 | 3.3 | Yes |
| 33770 |  CHEMBL144731 | C35H37F2N3O4 | 601.695 | 8 / 0 | 4.8 | No |
| 442998 |  CHEMBL3342866 | C25H33N3O5S | 487.615 | 8 / 0 | 2.7 | Yes |
| 34117 |  CHEMBL417954 | C19H21F5N4O3 | 448.394 | 10 / 1 | 2.7 | Yes |
| 34169 |  CHEMBL511411 | C12H11FN2 | 202.232 | 2 / 0 | 1.9 | Yes |
| 443026 |  CHEMBL3342873 | C20H31N3O5S | 425.544 | 8 / 0 | 1.1 | Yes |
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