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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	corynanthine
Molecular formula	C21H26N2O3
IUPAC name	methyl (1S,15R,18S,19S,20S)-18-hydroxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylate
Molecular weight	354.45
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	2.9
Synonyms	MEGxp0_001869 NCGC00015878-02 Rauhimbine Yohimban-16-carboxylic acid, 17-hydroxy-, methyl ester, (16beta,17alpha)- (9CI) AC1L3OSP BPBio1_000436 methyl (3S,4S,4aS,5aS,14aR)-3-hydroxy-1,2,3,4,5,11,14,14a,4a,5a-decahydrobenzo [3,2-g]indolo[2,3-a]quinolizine-4-carboxylate Prestwick0_000578 SMR000857089 17\|A-Hydroxyyohimban-16\|A-carboxylic acid methyl ester BDBM50027058 CCG-208620 F5Z7C9RK8U Lopac-R-104 MLS001332620 Prestwick3_000578 UNII-F5Z7C9RK8U Bio1_001450 CHEMBL31410 Methyl (16beta,17alpha)-17-hydroxyyohimban-16-carboxylate NCGC00016294-06 SCHEMBL178061 Yohimban-16beta-carboxylic acid, 17alpha-hydroxy-, methyl ester (8CI) (1S,2S,4aR,13bS,14aS)-2-Hydroxy-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydro-indolo[2'''',3'''':3,4]pyrido[1,2-b]isoquinoline-1-carboxylic acid methyl ester ACon1_002064 BRD-K06467078-003-03-7 D00GEE GTPL5345 methyl hydroxy[?]carboxylate Prestwick1_000578 SPBio_002615 2-Hydroxy-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydro-indolo[2'',3'':3,4]pyrido[1,2-b]isoquinoline-1-carboxylic acid methyl ester Bio1_000472 CHEBI:92122 Lopac-Y-3125 NCGC00015878-01 Rauhimbin Yohimban-16-carboxylic acid, 17-hydroxy-, methyl ester, (16beta,17alpha)- 6613AF BLGXFZZNTVWLAY-DKJBZYCGSA-N Corynanthin methyl (1S,15R,18S,19S,20S)-18-hydroxy-3,13-diazapentacyclo[11.8.0.0^{2,10}.0^{4,9}.0^{15,20}]henicosa-2(10),4,6,8-tetraene-19-carboxylate NSC 407306 SMP1_000080 ZINC3861548 (1S,2S,4aR,13bS,14aS)-2-Hydroxy-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydro-indolo[2'',3'':3,4]pyrido[1,2-b]isoquinoline-1-carboxylic acid methyl ester AKOS024282584 BSPBio_000396 EINECS 207-590-0 HMS2231N15 MLS001332619 Prestwick2_000578 ST057156 483-10-3 Bio1_000961 [ Show all ]
Inchi Key	BLGXFZZNTVWLAY-DKJBZYCGSA-N
Inchi ID	InChI=1S/C21H26N2O3/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24/h2-5,12,15,17-19,22,24H,6-11H2,1H3/t12-,15-,17-,18-,19-/m0/s1
PubChem CID	92766
ChEMBL	CHEMBL31410
IUPHAR	N/A
BindingDB	50027058
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
26563	Alpha-1A adrenergic receptor	P35348	ADRA1A	Homo sapiens (Human)	466
26566	Alpha-1B adrenergic receptor	P35368	ADRA1B	Homo sapiens (Human)	520
26570	Alpha-1D adrenergic receptor	P25100	ADRA1D	Homo sapiens (Human)	572
26564	Alpha-2A adrenergic receptor	P08913	ADRA2A	Homo sapiens (Human)	450
26567	Alpha-2B adrenergic receptor	P18089	ADRA2B	Homo sapiens (Human)	450
26568	Alpha-2C adrenergic receptor	P18825	ADRA2C	Homo sapiens (Human)	462
26565	Muscarinic acetylcholine receptor M1	P08482	Chrm1	Rattus norvegicus (Rat)	460
26569	Thyrotropin receptor	P16473	TSHR	Homo sapiens (Human)	764

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