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Name | Alpha-1D adrenergic receptor |
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Species | Homo sapiens (Human) |
Gene | ADRA1D |
Synonym | alpha1a/d-adrenoceptor adrenergic receptor delta1 Gpcr8 Adrd1 ADRA1R [ Show all ] |
Disease | Urinary incontinence Benign prostatic hyperplasia Congestive heart failure Diabetes Erectile dysfunction [ Show all ] |
Length | 572 |
Amino acid sequence | MTFRDLLSVSFEGPRPDSSAGGSSAGGGGGSAGGAAPSEGPAVGGVPGGAGGGGGVVGAGSGEDNRSSAGEPGSAGAGGDVNGTAAVGGLVVSAQGVGVGVFLAAFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVLGFWAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWVVALVVSVGPLLGWKEPVPPDERFCGITEEAGYAVFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGVKRERGKASEVVLRIHCRGAATGADGAHGMRSAKGHTFRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRRRRPLWRVYGHHWRASTSGLRQDCAPSSGDAPPGAPLALTALPDPDPEPPGTPEMQAPVASRRKPPSAFREWRLLGPFRRPTTQLRAKVSSLSHKIRAGGAQRAEAACAQRSEVEAVSLGVPHEVAEGATCQAYELADYSNLRETDI |
UniProt | P25100 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | T53381 |
ChEMBL | CHEMBL223 |
IUPHAR | 24 |
DrugBank | BE0004863, BE0000715 |
Name | CHEMBL1946783 |
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Molecular formula | C31H34N2O6 |
IUPAC name | 5-[[4-(2-methoxyphenyl)piperazin-1-yl]methyl]-2,2-diphenylcyclopentan-1-one;oxalic acid |
Molecular weight | 530.621 |
Hydrogen bond acceptor | 8 |
Hydrogen bond donor | 2 |
XlogP | None |
Synonyms | N/A |
Inchi Key | APRDDCAAWFCTQQ-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C29H32N2O2.C2H2O4/c1-33-27-15-9-8-14-26(27)31-20-18-30(19-21-31)22-23-16-17-29(28(23)32,24-10-4-2-5-11-24)25-12-6-3-7-13-25;3-1(4)2(5)6/h2-15,23H,16-22H2,1H3;(H,3,4)(H,5,6) |
PubChem CID | 56946578 |
ChEMBL | CHEMBL1946783 |
IUPHAR | N/A |
BindingDB | N/A |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. Partition coefficient log P of this ligand is not available. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 154.88 nM | PMID22145629 | ChEMBL |
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